Dietary phytoestrogen intakes and cognitive function during the menopausal transition: Results from the Study of Women's Health Across the Nation Phytoestrogen Study

Gail A. Greendale, Mei Hua Huang, Katherine Leung, Sybil L. Crawford, Ellen B Gold, Richard Wight, L Elaine Waetjen, Arun S. Karlamangla

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

OBJECTIVE: Phytoestrogens, which consist mainly of isoflavones, lignans, and coumestans have estrogenic and anti-inflammatory properties. Previous research suggests that higher dietary or supplemental intakes of isoflavones and lignans are related to better cognitive performance in middle-aged and older women. METHODS: We conducted longitudinal analysis of dietary phytoestrogens and cognitive performance in a cohort of African American, white, Chinese, and Japanese women undergoing the menopausal transition. The tests were Symbol Digit Modalities, East Boston Memory, and Digits Span Backward. Phytoestrogens were assessed using the Food Frequency Questionnaire. We modeled each cognitive score as a function of concurrent value of the primary predictors (highest tertile of isoflavones, lignans, or coumestrol) and covariates including the menopausal transition stage. RESULTS: Coumestrol and isoflavone intakes were 10 and 25 times greater, respectively, in Asian than in non-Asian participants. During late perimenopause and postmenopause, Asian women with high isoflavone intakes did better on processing speed, but during early perimenopause and postmenopause, high-isoflavone Asian consumers performed worse on verbal memory. The highest isoflavone consumers among non-Asians likewise posted lower verbal memory scores during early perimenopause. A verbal memory benefit of higher dietary lignan consumption was apparent only during late perimenopause, when women from all ethnic/racial groups who were in the highest tertile of intake demonstrated a small advantage. Coumestrol was unrelated to cognitive performance. CONCLUSIONS: The cognitive effects of dietary phytoestrogens are small, seem to be class-specific, vary by menopause stage and cognitive domain, and differ among ethnic/racial groups (but whether this is related to dose or to host factors cannot be discerned).

Original languageEnglish (US)
Pages (from-to)894-903
Number of pages10
JournalMenopause
Volume19
Issue number8
DOIs
StatePublished - Aug 2012

Fingerprint

Phytoestrogens
Isoflavones
Women's Health
Cognition
Perimenopause
Lignans
Coumestrol
Postmenopause
Ethnic Groups
Menopause
African Americans
Anti-Inflammatory Agents
Food
Research

ASJC Scopus subject areas

  • Obstetrics and Gynecology

Cite this

Dietary phytoestrogen intakes and cognitive function during the menopausal transition : Results from the Study of Women's Health Across the Nation Phytoestrogen Study. / Greendale, Gail A.; Huang, Mei Hua; Leung, Katherine; Crawford, Sybil L.; Gold, Ellen B; Wight, Richard; Waetjen, L Elaine; Karlamangla, Arun S.

In: Menopause, Vol. 19, No. 8, 08.2012, p. 894-903.

Research output: Contribution to journalArticle

Greendale, Gail A. ; Huang, Mei Hua ; Leung, Katherine ; Crawford, Sybil L. ; Gold, Ellen B ; Wight, Richard ; Waetjen, L Elaine ; Karlamangla, Arun S. / Dietary phytoestrogen intakes and cognitive function during the menopausal transition : Results from the Study of Women's Health Across the Nation Phytoestrogen Study. In: Menopause. 2012 ; Vol. 19, No. 8. pp. 894-903.
@article{cc4498ba135443cb965f8ac0b0a0af8a,
title = "Dietary phytoestrogen intakes and cognitive function during the menopausal transition: Results from the Study of Women's Health Across the Nation Phytoestrogen Study",
abstract = "OBJECTIVE: Phytoestrogens, which consist mainly of isoflavones, lignans, and coumestans have estrogenic and anti-inflammatory properties. Previous research suggests that higher dietary or supplemental intakes of isoflavones and lignans are related to better cognitive performance in middle-aged and older women. METHODS: We conducted longitudinal analysis of dietary phytoestrogens and cognitive performance in a cohort of African American, white, Chinese, and Japanese women undergoing the menopausal transition. The tests were Symbol Digit Modalities, East Boston Memory, and Digits Span Backward. Phytoestrogens were assessed using the Food Frequency Questionnaire. We modeled each cognitive score as a function of concurrent value of the primary predictors (highest tertile of isoflavones, lignans, or coumestrol) and covariates including the menopausal transition stage. RESULTS: Coumestrol and isoflavone intakes were 10 and 25 times greater, respectively, in Asian than in non-Asian participants. During late perimenopause and postmenopause, Asian women with high isoflavone intakes did better on processing speed, but during early perimenopause and postmenopause, high-isoflavone Asian consumers performed worse on verbal memory. The highest isoflavone consumers among non-Asians likewise posted lower verbal memory scores during early perimenopause. A verbal memory benefit of higher dietary lignan consumption was apparent only during late perimenopause, when women from all ethnic/racial groups who were in the highest tertile of intake demonstrated a small advantage. Coumestrol was unrelated to cognitive performance. CONCLUSIONS: The cognitive effects of dietary phytoestrogens are small, seem to be class-specific, vary by menopause stage and cognitive domain, and differ among ethnic/racial groups (but whether this is related to dose or to host factors cannot be discerned).",
author = "Greendale, {Gail A.} and Huang, {Mei Hua} and Katherine Leung and Crawford, {Sybil L.} and Gold, {Ellen B} and Richard Wight and Waetjen, {L Elaine} and Karlamangla, {Arun S.}",
year = "2012",
month = "8",
doi = "10.1097/gme.0b013e318242a654",
language = "English (US)",
volume = "19",
pages = "894--903",
journal = "Menopause",
issn = "1072-3714",
publisher = "Lippincott Williams and Wilkins",
number = "8",

}

TY - JOUR

T1 - Dietary phytoestrogen intakes and cognitive function during the menopausal transition

T2 - Results from the Study of Women's Health Across the Nation Phytoestrogen Study

AU - Greendale, Gail A.

AU - Huang, Mei Hua

AU - Leung, Katherine

AU - Crawford, Sybil L.

AU - Gold, Ellen B

AU - Wight, Richard

AU - Waetjen, L Elaine

AU - Karlamangla, Arun S.

PY - 2012/8

Y1 - 2012/8

N2 - OBJECTIVE: Phytoestrogens, which consist mainly of isoflavones, lignans, and coumestans have estrogenic and anti-inflammatory properties. Previous research suggests that higher dietary or supplemental intakes of isoflavones and lignans are related to better cognitive performance in middle-aged and older women. METHODS: We conducted longitudinal analysis of dietary phytoestrogens and cognitive performance in a cohort of African American, white, Chinese, and Japanese women undergoing the menopausal transition. The tests were Symbol Digit Modalities, East Boston Memory, and Digits Span Backward. Phytoestrogens were assessed using the Food Frequency Questionnaire. We modeled each cognitive score as a function of concurrent value of the primary predictors (highest tertile of isoflavones, lignans, or coumestrol) and covariates including the menopausal transition stage. RESULTS: Coumestrol and isoflavone intakes were 10 and 25 times greater, respectively, in Asian than in non-Asian participants. During late perimenopause and postmenopause, Asian women with high isoflavone intakes did better on processing speed, but during early perimenopause and postmenopause, high-isoflavone Asian consumers performed worse on verbal memory. The highest isoflavone consumers among non-Asians likewise posted lower verbal memory scores during early perimenopause. A verbal memory benefit of higher dietary lignan consumption was apparent only during late perimenopause, when women from all ethnic/racial groups who were in the highest tertile of intake demonstrated a small advantage. Coumestrol was unrelated to cognitive performance. CONCLUSIONS: The cognitive effects of dietary phytoestrogens are small, seem to be class-specific, vary by menopause stage and cognitive domain, and differ among ethnic/racial groups (but whether this is related to dose or to host factors cannot be discerned).

AB - OBJECTIVE: Phytoestrogens, which consist mainly of isoflavones, lignans, and coumestans have estrogenic and anti-inflammatory properties. Previous research suggests that higher dietary or supplemental intakes of isoflavones and lignans are related to better cognitive performance in middle-aged and older women. METHODS: We conducted longitudinal analysis of dietary phytoestrogens and cognitive performance in a cohort of African American, white, Chinese, and Japanese women undergoing the menopausal transition. The tests were Symbol Digit Modalities, East Boston Memory, and Digits Span Backward. Phytoestrogens were assessed using the Food Frequency Questionnaire. We modeled each cognitive score as a function of concurrent value of the primary predictors (highest tertile of isoflavones, lignans, or coumestrol) and covariates including the menopausal transition stage. RESULTS: Coumestrol and isoflavone intakes were 10 and 25 times greater, respectively, in Asian than in non-Asian participants. During late perimenopause and postmenopause, Asian women with high isoflavone intakes did better on processing speed, but during early perimenopause and postmenopause, high-isoflavone Asian consumers performed worse on verbal memory. The highest isoflavone consumers among non-Asians likewise posted lower verbal memory scores during early perimenopause. A verbal memory benefit of higher dietary lignan consumption was apparent only during late perimenopause, when women from all ethnic/racial groups who were in the highest tertile of intake demonstrated a small advantage. Coumestrol was unrelated to cognitive performance. CONCLUSIONS: The cognitive effects of dietary phytoestrogens are small, seem to be class-specific, vary by menopause stage and cognitive domain, and differ among ethnic/racial groups (but whether this is related to dose or to host factors cannot be discerned).

UR - http://www.scopus.com/inward/record.url?scp=84864277675&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84864277675&partnerID=8YFLogxK

U2 - 10.1097/gme.0b013e318242a654

DO - 10.1097/gme.0b013e318242a654

M3 - Article

C2 - 22415567

AN - SCOPUS:84864277675

VL - 19

SP - 894

EP - 903

JO - Menopause

JF - Menopause

SN - 1072-3714

IS - 8

ER -