Dietary Iron Intake Is Positively Associated with Hemoglobin Concentration during Infancy but Not during the Second Year of Life

Torbjörn Lind, Olle Hernell, Bo Lönnerdal, Hans Stenlund, Magnus Domellöf, Lars Åke Persson

Research output: Contribution to journalArticle

32 Citations (Scopus)

Abstract

Iron status during infancy and early childhood reflects highly dynamic processes, which are affected by both internal and external factors. The regulation of iron metabolism seems to be subjected to developmental changes during infancy, although the exact nature of these changes and their implications are not fully understood. We wanted to explore the association between dietary iron intake and indicators of iron status, and to assess temporal changes in these variables. This was done by secondary analysis of data from a recently conducted dietary intervention trial in which healthy, term, well-nourished infants were randomly assigned to consume iron-fortified infant cereals with regular or low phytate content, or iron-fortified infant formula. Dietary iron intake from 6 to 8 mo and from 9 to 11 mo was associated with hemoglobin (Hb) concentration at 9 mo (r = 0.27, P < 0.001) and 12 mo (r = 0.21, P = 0.001), respectively, but iron intake from 12 to 18 mo was not associated with Hb at 18 mo. In contrast, iron intake from 6 to 11 mo was not associated with serum ferritin (S-Ft) at 9 or 12 mo, whereas iron intake from 12 to 17 mo was positively associated with S-Ft at 18 mo (r = 0.14, P = 0.032). These shifts in associations between dietary iron intake, and Hb and S-Ft, respectively, may be due to developmental changes in the channeling of dietary iron to erythropoiesis relative to storage, in the absence of iron deficiency anemia. These observations should be taken into consideration when evaluating iron nutritional status during infancy and early childhood.

Original languageEnglish (US)
Pages (from-to)1064-1070
Number of pages7
JournalJournal of Nutrition
Volume134
Issue number5
StatePublished - May 2004

Fingerprint

Dietary Iron
infancy
hemoglobin
Hemoglobins
Iron
iron
Ferritins
ferritin
Serum
childhood
Phytic Acid
Infant Formula
Iron-Deficiency Anemias
Erythropoiesis
Nutritional Status
erythropoiesis
iron deficiency anemia
infant formulas
phytic acid

Keywords

  • Ferritin
  • Hemoglobin
  • Infants
  • Iron intake
  • Transferrin receptor

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Food Science

Cite this

Lind, T., Hernell, O., Lönnerdal, B., Stenlund, H., Domellöf, M., & Persson, L. Å. (2004). Dietary Iron Intake Is Positively Associated with Hemoglobin Concentration during Infancy but Not during the Second Year of Life. Journal of Nutrition, 134(5), 1064-1070.

Dietary Iron Intake Is Positively Associated with Hemoglobin Concentration during Infancy but Not during the Second Year of Life. / Lind, Torbjörn; Hernell, Olle; Lönnerdal, Bo; Stenlund, Hans; Domellöf, Magnus; Persson, Lars Åke.

In: Journal of Nutrition, Vol. 134, No. 5, 05.2004, p. 1064-1070.

Research output: Contribution to journalArticle

Lind, T, Hernell, O, Lönnerdal, B, Stenlund, H, Domellöf, M & Persson, LÅ 2004, 'Dietary Iron Intake Is Positively Associated with Hemoglobin Concentration during Infancy but Not during the Second Year of Life', Journal of Nutrition, vol. 134, no. 5, pp. 1064-1070.
Lind T, Hernell O, Lönnerdal B, Stenlund H, Domellöf M, Persson LÅ. Dietary Iron Intake Is Positively Associated with Hemoglobin Concentration during Infancy but Not during the Second Year of Life. Journal of Nutrition. 2004 May;134(5):1064-1070.
Lind, Torbjörn ; Hernell, Olle ; Lönnerdal, Bo ; Stenlund, Hans ; Domellöf, Magnus ; Persson, Lars Åke. / Dietary Iron Intake Is Positively Associated with Hemoglobin Concentration during Infancy but Not during the Second Year of Life. In: Journal of Nutrition. 2004 ; Vol. 134, No. 5. pp. 1064-1070.
@article{3bc65272e2754bf58518cc7c9520e4d4,
title = "Dietary Iron Intake Is Positively Associated with Hemoglobin Concentration during Infancy but Not during the Second Year of Life",
abstract = "Iron status during infancy and early childhood reflects highly dynamic processes, which are affected by both internal and external factors. The regulation of iron metabolism seems to be subjected to developmental changes during infancy, although the exact nature of these changes and their implications are not fully understood. We wanted to explore the association between dietary iron intake and indicators of iron status, and to assess temporal changes in these variables. This was done by secondary analysis of data from a recently conducted dietary intervention trial in which healthy, term, well-nourished infants were randomly assigned to consume iron-fortified infant cereals with regular or low phytate content, or iron-fortified infant formula. Dietary iron intake from 6 to 8 mo and from 9 to 11 mo was associated with hemoglobin (Hb) concentration at 9 mo (r = 0.27, P < 0.001) and 12 mo (r = 0.21, P = 0.001), respectively, but iron intake from 12 to 18 mo was not associated with Hb at 18 mo. In contrast, iron intake from 6 to 11 mo was not associated with serum ferritin (S-Ft) at 9 or 12 mo, whereas iron intake from 12 to 17 mo was positively associated with S-Ft at 18 mo (r = 0.14, P = 0.032). These shifts in associations between dietary iron intake, and Hb and S-Ft, respectively, may be due to developmental changes in the channeling of dietary iron to erythropoiesis relative to storage, in the absence of iron deficiency anemia. These observations should be taken into consideration when evaluating iron nutritional status during infancy and early childhood.",
keywords = "Ferritin, Hemoglobin, Infants, Iron intake, Transferrin receptor",
author = "Torbj{\"o}rn Lind and Olle Hernell and Bo L{\"o}nnerdal and Hans Stenlund and Magnus Domell{\"o}f and Persson, {Lars {\AA}ke}",
year = "2004",
month = "5",
language = "English (US)",
volume = "134",
pages = "1064--1070",
journal = "Journal of Nutrition",
issn = "0022-3166",
publisher = "American Society for Nutrition",
number = "5",

}

TY - JOUR

T1 - Dietary Iron Intake Is Positively Associated with Hemoglobin Concentration during Infancy but Not during the Second Year of Life

AU - Lind, Torbjörn

AU - Hernell, Olle

AU - Lönnerdal, Bo

AU - Stenlund, Hans

AU - Domellöf, Magnus

AU - Persson, Lars Åke

PY - 2004/5

Y1 - 2004/5

N2 - Iron status during infancy and early childhood reflects highly dynamic processes, which are affected by both internal and external factors. The regulation of iron metabolism seems to be subjected to developmental changes during infancy, although the exact nature of these changes and their implications are not fully understood. We wanted to explore the association between dietary iron intake and indicators of iron status, and to assess temporal changes in these variables. This was done by secondary analysis of data from a recently conducted dietary intervention trial in which healthy, term, well-nourished infants were randomly assigned to consume iron-fortified infant cereals with regular or low phytate content, or iron-fortified infant formula. Dietary iron intake from 6 to 8 mo and from 9 to 11 mo was associated with hemoglobin (Hb) concentration at 9 mo (r = 0.27, P < 0.001) and 12 mo (r = 0.21, P = 0.001), respectively, but iron intake from 12 to 18 mo was not associated with Hb at 18 mo. In contrast, iron intake from 6 to 11 mo was not associated with serum ferritin (S-Ft) at 9 or 12 mo, whereas iron intake from 12 to 17 mo was positively associated with S-Ft at 18 mo (r = 0.14, P = 0.032). These shifts in associations between dietary iron intake, and Hb and S-Ft, respectively, may be due to developmental changes in the channeling of dietary iron to erythropoiesis relative to storage, in the absence of iron deficiency anemia. These observations should be taken into consideration when evaluating iron nutritional status during infancy and early childhood.

AB - Iron status during infancy and early childhood reflects highly dynamic processes, which are affected by both internal and external factors. The regulation of iron metabolism seems to be subjected to developmental changes during infancy, although the exact nature of these changes and their implications are not fully understood. We wanted to explore the association between dietary iron intake and indicators of iron status, and to assess temporal changes in these variables. This was done by secondary analysis of data from a recently conducted dietary intervention trial in which healthy, term, well-nourished infants were randomly assigned to consume iron-fortified infant cereals with regular or low phytate content, or iron-fortified infant formula. Dietary iron intake from 6 to 8 mo and from 9 to 11 mo was associated with hemoglobin (Hb) concentration at 9 mo (r = 0.27, P < 0.001) and 12 mo (r = 0.21, P = 0.001), respectively, but iron intake from 12 to 18 mo was not associated with Hb at 18 mo. In contrast, iron intake from 6 to 11 mo was not associated with serum ferritin (S-Ft) at 9 or 12 mo, whereas iron intake from 12 to 17 mo was positively associated with S-Ft at 18 mo (r = 0.14, P = 0.032). These shifts in associations between dietary iron intake, and Hb and S-Ft, respectively, may be due to developmental changes in the channeling of dietary iron to erythropoiesis relative to storage, in the absence of iron deficiency anemia. These observations should be taken into consideration when evaluating iron nutritional status during infancy and early childhood.

KW - Ferritin

KW - Hemoglobin

KW - Infants

KW - Iron intake

KW - Transferrin receptor

UR - http://www.scopus.com/inward/record.url?scp=2442597765&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=2442597765&partnerID=8YFLogxK

M3 - Article

C2 - 15113946

AN - SCOPUS:2442597765

VL - 134

SP - 1064

EP - 1070

JO - Journal of Nutrition

JF - Journal of Nutrition

SN - 0022-3166

IS - 5

ER -