Dietary immunoregulation of transfusion-induced immunosuppression

Richard V Perez, R. Munda, J. W. Alexander

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Dietary supplementation with fatty acids was carried out to examine whether the type and timing of dietary manipulation would have an effect on transfusion-induced immunosuppression in a rat cardiac transplant model. Linoleic acid (LA), oleic acid (OA), and fish oil (FO) were used because of their different effects on arachidonic acid (AA) metabolism. Pretransplant inhibition of AA metabolism (OA) shortened graft survival when compared with water-fed controls. Posttransplant LA (AA precursor) significantly prolonged graft survival. Pre- and posttransplant supplementation of LA and OA resulted in even more prolongation and shortening of graft survival, respectively. These findings suggest that transfusion-induced immunosuppression is partially mediated by AA metabolites, which are necessary for the pretransplant induction and posttransplant maintenance of the suppressed state. Dietary immunoregulation of transfusion induced immunosuppression is possible. The timing of dietary intervention and type of lipid supplementation is important in regulation of the immune response.

Original languageEnglish (US)
Pages (from-to)614-617
Number of pages4
JournalTransplantation
Volume45
Issue number3
StatePublished - 1988
Externally publishedYes

Fingerprint

Arachidonic Acid
Immunosuppression
Graft Survival
Linoleic Acid
Oleic Acid
Fish Oils
Dietary Supplements
Fatty Acids
Maintenance
Transplants
Lipids
Water

ASJC Scopus subject areas

  • Immunology
  • Transplantation

Cite this

Dietary immunoregulation of transfusion-induced immunosuppression. / Perez, Richard V; Munda, R.; Alexander, J. W.

In: Transplantation, Vol. 45, No. 3, 1988, p. 614-617.

Research output: Contribution to journalArticle

Perez, RV, Munda, R & Alexander, JW 1988, 'Dietary immunoregulation of transfusion-induced immunosuppression', Transplantation, vol. 45, no. 3, pp. 614-617.
Perez, Richard V ; Munda, R. ; Alexander, J. W. / Dietary immunoregulation of transfusion-induced immunosuppression. In: Transplantation. 1988 ; Vol. 45, No. 3. pp. 614-617.
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