Dietary fructose

Implications for dysregulation of energy homeostasis and lipid/carbohydrate metabolism

Research output: Contribution to journalArticle

436 Citations (Scopus)

Abstract

Fructose intake and the prevalence of obesity have both increased over the past two to three decades. Compared with glucose, the hepatic metabolism of fructose favors lipogenesis, which may contribute to hyperlipidemia and obesity. Fructose does not increase insulin and leptin or suppress ghrelin, which suggests an endocrine mechanism by which it induces a positive energy balance. This review examines the available data on the effects of dietary fructose on energy homeostasis and lipid/carbohydrate metabolism. Recent publications, studies in human subjects, and areas in which additional research is needed are emphasized.

Original languageEnglish (US)
Pages (from-to)133-137
Number of pages5
JournalNutrition Reviews
Volume63
Issue number5
DOIs
StatePublished - May 2005

Fingerprint

Carbohydrate Metabolism
carbohydrate metabolism
Fructose
Lipid Metabolism
lipid metabolism
fructose
homeostasis
Homeostasis
energy
obesity
Obesity
ghrelin
Lipogenesis
Ghrelin
lipogenesis
hyperlipidemia
Leptin
Hyperlipidemias
leptin
energy balance

Keywords

  • Cardiovascular disease
  • Diabetes
  • Leptin
  • Obesity
  • Triglycerides

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Food Science

Cite this

Dietary fructose : Implications for dysregulation of energy homeostasis and lipid/carbohydrate metabolism. / Havel, Peter J.

In: Nutrition Reviews, Vol. 63, No. 5, 05.2005, p. 133-137.

Research output: Contribution to journalArticle

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