Dietary fat, hypothalamic glutamate decarboxylase, and food intake of streptozotocin-diabetic rats

J. L. Beverly, M. H. Oster, T. W. Castonguay, J. S. Stern

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Abstract

The association among changes in glucose status, glutamate decarboxylase (GAD) activity, and food intake was evaluated in several hypothalamic areas of streptozotocin-diabetic rats fed a low- (12% of calories as fat) or high-fat diet (59% of calories as fat). Control rats consumed ~90 kcal/24 h of either diet, whereas diabetic rats consumed ~150 kcal/24 h of the low-fat diet and ~100 kcal/24 h of the high-fat diet. At the end of the study, diabetic rats fed the high-fat diet weighed more and had higher retroperitoneal fat depot weights (P < 0.05) than diabetic rats fed the low-fat diet. In diabetic rats, GAD activity was 15-20% higher in the ventromedial nucleus (P < 0.01) but similar to controls in the lateral hypothalamus, paraventricular nucleus, and area postrema. Diet did not affect GAD activity in the brain areas studied. The increase in ventromedial nucleus GAD activity was not associated with the level of food intake and was the likely result of altered glucose homeostasis in diabetic rats.

Original languageEnglish (US)
JournalAmerican Journal of Physiology - Regulatory Integrative and Comparative Physiology
Volume261
Issue number6 30-6
StatePublished - 1991

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Keywords

  • γ-Aminobutyric acid
  • Diabetes
  • Food intake regulation

ASJC Scopus subject areas

  • Physiology

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