Dietary fat and risk of lung cancer in a pooled analysis of prospective studies

Stephanie A. Smith-Warner, John Ritz, David J. Hunter, Demetrius Albanes, W. Lawrence Beeson, Piet A. Van den Brandt, Graham Colditz, Aaron R. Folsom, Gary E. Fraser, Jo L. Freudenheim, Edward Giovannucci, R. Alexandra Goldbohm, Saxon Graham, Lawrence H. Kushi, Anthony B. Miller, Thomas E. Rohan, Frank E. Speizer, Jarmo Virtamo, Walter C. Willett

Research output: Contribution to journalArticle

54 Citations (Scopus)

Abstract

Lung cancer rates are highest in countries with the greatest fat intakes. In several case-control studies, positive associations have been observed between lung cancer and intakes of total and saturated fat, particularly among nonsmokers. We analyzed the association between fat and cholesterol intakes and lung cancer risk in eight prospective cohort studies that met predefined criteria. Among the 280,419 female and 149,862 male participants who were followed for up to 6-16 years, 3,188 lung cancer cases were documented. Using the Cox proportional hazards model, we calculated study-specific relative risks that were adjusted for smoking history and other potential risk factors. Pooled relative risks were computed using a random effects model. Fat intake was not associated with lung cancer risk. For an increment of 5% of energy from fat, the pooled multivariate relative risks were 1.01 [95% confidence interval (CI), 0.98-1.05] for total, 1.03 (95% CI, 0.96-1.11) for saturated, 1.01 (95% CI, 0.93-1.10) for monounsaturated, and 0.99 (95% CI, 0.90-1.10) for polyunsaturated fat. No associations were observed between intakes of total or specific types of fat and lung cancer risk among never, past, or current smokers. Dietary cholesterol was not associated with lung cancer incidence [for a 100-mg/day increment, the pooled multivariate relative risk was 1.01 (95% CI, 0.97-1.05)]. There was no statistically significant heterogeneity among studies or by sex. These data do not support an important relation between fat or cholesterol intakes and lung cancer risk. The means to prevent this important disease remains avoidance of smoking.

Original languageEnglish (US)
Pages (from-to)987-992
Number of pages6
JournalCancer Epidemiology Biomarkers and Prevention
Volume11
Issue number10 I
StatePublished - Oct 2002
Externally publishedYes

Fingerprint

Dietary Fats
Lung Neoplasms
Fats
Prospective Studies
Confidence Intervals
Smoking
Cholesterol
Dietary Cholesterol
Proportional Hazards Models
Case-Control Studies
Cohort Studies
History
Incidence

ASJC Scopus subject areas

  • Epidemiology
  • Oncology

Cite this

Smith-Warner, S. A., Ritz, J., Hunter, D. J., Albanes, D., Beeson, W. L., Van den Brandt, P. A., ... Willett, W. C. (2002). Dietary fat and risk of lung cancer in a pooled analysis of prospective studies. Cancer Epidemiology Biomarkers and Prevention, 11(10 I), 987-992.

Dietary fat and risk of lung cancer in a pooled analysis of prospective studies. / Smith-Warner, Stephanie A.; Ritz, John; Hunter, David J.; Albanes, Demetrius; Beeson, W. Lawrence; Van den Brandt, Piet A.; Colditz, Graham; Folsom, Aaron R.; Fraser, Gary E.; Freudenheim, Jo L.; Giovannucci, Edward; Goldbohm, R. Alexandra; Graham, Saxon; Kushi, Lawrence H.; Miller, Anthony B.; Rohan, Thomas E.; Speizer, Frank E.; Virtamo, Jarmo; Willett, Walter C.

In: Cancer Epidemiology Biomarkers and Prevention, Vol. 11, No. 10 I, 10.2002, p. 987-992.

Research output: Contribution to journalArticle

Smith-Warner, SA, Ritz, J, Hunter, DJ, Albanes, D, Beeson, WL, Van den Brandt, PA, Colditz, G, Folsom, AR, Fraser, GE, Freudenheim, JL, Giovannucci, E, Goldbohm, RA, Graham, S, Kushi, LH, Miller, AB, Rohan, TE, Speizer, FE, Virtamo, J & Willett, WC 2002, 'Dietary fat and risk of lung cancer in a pooled analysis of prospective studies', Cancer Epidemiology Biomarkers and Prevention, vol. 11, no. 10 I, pp. 987-992.
Smith-Warner SA, Ritz J, Hunter DJ, Albanes D, Beeson WL, Van den Brandt PA et al. Dietary fat and risk of lung cancer in a pooled analysis of prospective studies. Cancer Epidemiology Biomarkers and Prevention. 2002 Oct;11(10 I):987-992.
Smith-Warner, Stephanie A. ; Ritz, John ; Hunter, David J. ; Albanes, Demetrius ; Beeson, W. Lawrence ; Van den Brandt, Piet A. ; Colditz, Graham ; Folsom, Aaron R. ; Fraser, Gary E. ; Freudenheim, Jo L. ; Giovannucci, Edward ; Goldbohm, R. Alexandra ; Graham, Saxon ; Kushi, Lawrence H. ; Miller, Anthony B. ; Rohan, Thomas E. ; Speizer, Frank E. ; Virtamo, Jarmo ; Willett, Walter C. / Dietary fat and risk of lung cancer in a pooled analysis of prospective studies. In: Cancer Epidemiology Biomarkers and Prevention. 2002 ; Vol. 11, No. 10 I. pp. 987-992.
@article{61d7770ee03f4dc58f667f134dd62076,
title = "Dietary fat and risk of lung cancer in a pooled analysis of prospective studies",
abstract = "Lung cancer rates are highest in countries with the greatest fat intakes. In several case-control studies, positive associations have been observed between lung cancer and intakes of total and saturated fat, particularly among nonsmokers. We analyzed the association between fat and cholesterol intakes and lung cancer risk in eight prospective cohort studies that met predefined criteria. Among the 280,419 female and 149,862 male participants who were followed for up to 6-16 years, 3,188 lung cancer cases were documented. Using the Cox proportional hazards model, we calculated study-specific relative risks that were adjusted for smoking history and other potential risk factors. Pooled relative risks were computed using a random effects model. Fat intake was not associated with lung cancer risk. For an increment of 5{\%} of energy from fat, the pooled multivariate relative risks were 1.01 [95{\%} confidence interval (CI), 0.98-1.05] for total, 1.03 (95{\%} CI, 0.96-1.11) for saturated, 1.01 (95{\%} CI, 0.93-1.10) for monounsaturated, and 0.99 (95{\%} CI, 0.90-1.10) for polyunsaturated fat. No associations were observed between intakes of total or specific types of fat and lung cancer risk among never, past, or current smokers. Dietary cholesterol was not associated with lung cancer incidence [for a 100-mg/day increment, the pooled multivariate relative risk was 1.01 (95{\%} CI, 0.97-1.05)]. There was no statistically significant heterogeneity among studies or by sex. These data do not support an important relation between fat or cholesterol intakes and lung cancer risk. The means to prevent this important disease remains avoidance of smoking.",
author = "Smith-Warner, {Stephanie A.} and John Ritz and Hunter, {David J.} and Demetrius Albanes and Beeson, {W. Lawrence} and {Van den Brandt}, {Piet A.} and Graham Colditz and Folsom, {Aaron R.} and Fraser, {Gary E.} and Freudenheim, {Jo L.} and Edward Giovannucci and Goldbohm, {R. Alexandra} and Saxon Graham and Kushi, {Lawrence H.} and Miller, {Anthony B.} and Rohan, {Thomas E.} and Speizer, {Frank E.} and Jarmo Virtamo and Willett, {Walter C.}",
year = "2002",
month = "10",
language = "English (US)",
volume = "11",
pages = "987--992",
journal = "Cancer Epidemiology Biomarkers and Prevention",
issn = "1055-9965",
publisher = "American Association for Cancer Research Inc.",
number = "10 I",

}

TY - JOUR

T1 - Dietary fat and risk of lung cancer in a pooled analysis of prospective studies

AU - Smith-Warner, Stephanie A.

AU - Ritz, John

AU - Hunter, David J.

AU - Albanes, Demetrius

AU - Beeson, W. Lawrence

AU - Van den Brandt, Piet A.

AU - Colditz, Graham

AU - Folsom, Aaron R.

AU - Fraser, Gary E.

AU - Freudenheim, Jo L.

AU - Giovannucci, Edward

AU - Goldbohm, R. Alexandra

AU - Graham, Saxon

AU - Kushi, Lawrence H.

AU - Miller, Anthony B.

AU - Rohan, Thomas E.

AU - Speizer, Frank E.

AU - Virtamo, Jarmo

AU - Willett, Walter C.

PY - 2002/10

Y1 - 2002/10

N2 - Lung cancer rates are highest in countries with the greatest fat intakes. In several case-control studies, positive associations have been observed between lung cancer and intakes of total and saturated fat, particularly among nonsmokers. We analyzed the association between fat and cholesterol intakes and lung cancer risk in eight prospective cohort studies that met predefined criteria. Among the 280,419 female and 149,862 male participants who were followed for up to 6-16 years, 3,188 lung cancer cases were documented. Using the Cox proportional hazards model, we calculated study-specific relative risks that were adjusted for smoking history and other potential risk factors. Pooled relative risks were computed using a random effects model. Fat intake was not associated with lung cancer risk. For an increment of 5% of energy from fat, the pooled multivariate relative risks were 1.01 [95% confidence interval (CI), 0.98-1.05] for total, 1.03 (95% CI, 0.96-1.11) for saturated, 1.01 (95% CI, 0.93-1.10) for monounsaturated, and 0.99 (95% CI, 0.90-1.10) for polyunsaturated fat. No associations were observed between intakes of total or specific types of fat and lung cancer risk among never, past, or current smokers. Dietary cholesterol was not associated with lung cancer incidence [for a 100-mg/day increment, the pooled multivariate relative risk was 1.01 (95% CI, 0.97-1.05)]. There was no statistically significant heterogeneity among studies or by sex. These data do not support an important relation between fat or cholesterol intakes and lung cancer risk. The means to prevent this important disease remains avoidance of smoking.

AB - Lung cancer rates are highest in countries with the greatest fat intakes. In several case-control studies, positive associations have been observed between lung cancer and intakes of total and saturated fat, particularly among nonsmokers. We analyzed the association between fat and cholesterol intakes and lung cancer risk in eight prospective cohort studies that met predefined criteria. Among the 280,419 female and 149,862 male participants who were followed for up to 6-16 years, 3,188 lung cancer cases were documented. Using the Cox proportional hazards model, we calculated study-specific relative risks that were adjusted for smoking history and other potential risk factors. Pooled relative risks were computed using a random effects model. Fat intake was not associated with lung cancer risk. For an increment of 5% of energy from fat, the pooled multivariate relative risks were 1.01 [95% confidence interval (CI), 0.98-1.05] for total, 1.03 (95% CI, 0.96-1.11) for saturated, 1.01 (95% CI, 0.93-1.10) for monounsaturated, and 0.99 (95% CI, 0.90-1.10) for polyunsaturated fat. No associations were observed between intakes of total or specific types of fat and lung cancer risk among never, past, or current smokers. Dietary cholesterol was not associated with lung cancer incidence [for a 100-mg/day increment, the pooled multivariate relative risk was 1.01 (95% CI, 0.97-1.05)]. There was no statistically significant heterogeneity among studies or by sex. These data do not support an important relation between fat or cholesterol intakes and lung cancer risk. The means to prevent this important disease remains avoidance of smoking.

UR - http://www.scopus.com/inward/record.url?scp=0036801955&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0036801955&partnerID=8YFLogxK

M3 - Article

C2 - 12376497

AN - SCOPUS:0036801955

VL - 11

SP - 987

EP - 992

JO - Cancer Epidemiology Biomarkers and Prevention

JF - Cancer Epidemiology Biomarkers and Prevention

SN - 1055-9965

IS - 10 I

ER -