Dietary factors influencing zinc absorption

Bo Lönnerdal

Research output: Contribution to journalArticle

549 Citations (Scopus)

Abstract

Marginal zinc deficiency and suboptimal zinc status have been recognized in many groups of the population in both less developed and industrialized countries. Although the cause in some cases may be inadequate dietary intake of zinc, inhibitors of zinc absorption are most likely the most common causative factor, Phytate, which is present in staple foods like cereals, corn and rice, has a strong negative effect on zinc absorption from composite meals. Inositol hexaphosphates and pentaphosphates are the phytate forms that exert these negative effects, whereas the lower phosphates have no or little effect on zinc absorption. The removal or reduction of phytate by enzyme (phytase) treatment, precipitation methods, germination, fermentation or plant breeding/genetic engineering markedly improves zinc absorption. Iron can have a negative effect on zinc absorption, if given together in a supplement, whereas no effect is observed when the same amounts are present in a meal as fortificants. Cadmium, which is increasing in the environment, also inhibits zinc absorption. The amount of protein in a meal has a positive effect on zinc absorption, but individual proteins may act differently; e.g., casein has a modest inhibitory effect of zinc absorption compared with other protein sources. Amino acids, such as histidine and methionine, and other low-molecular-weight ions, such as EDTA and organic acids (e.g., citrate), are known to have a positive effect on zinc absorption and have been used for zinc supplements. Knowledge about dietary factors that inhibit zinc absorption and about ways to overcome or remove these factors is essential when designing strategies to improve the zinc nutrition of vulnerable groups.

Original languageEnglish (US)
JournalJournal of Nutrition
Volume130
Issue number5 SUPPL.
StatePublished - 2000

Fingerprint

Zinc
zinc
diet
Phytic Acid
meals (menu)
phytic acid
Meals
developed countries
6-Phytase
Proteins
Genetic Engineering
staple foods
phytases
Germination
Caseins
plant breeding
Cadmium
genetic engineering
Population Groups
histidine

Keywords

  • Inhibitors
  • Phytate
  • Zinc
  • Zinc absorption
  • Zinc bioavailability

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Food Science

Cite this

Lönnerdal, B. (2000). Dietary factors influencing zinc absorption. Journal of Nutrition, 130(5 SUPPL.).

Dietary factors influencing zinc absorption. / Lönnerdal, Bo.

In: Journal of Nutrition, Vol. 130, No. 5 SUPPL., 2000.

Research output: Contribution to journalArticle

Lönnerdal, B 2000, 'Dietary factors influencing zinc absorption', Journal of Nutrition, vol. 130, no. 5 SUPPL..
Lönnerdal, Bo. / Dietary factors influencing zinc absorption. In: Journal of Nutrition. 2000 ; Vol. 130, No. 5 SUPPL.
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