Dietary docosahexaenoic acid reverses nonalcoholic steatohepatitis and fibrosis caused by conjugated linoleic acid supplementation in mice

Yuriko Adkins, Dawn M. Fedor, Bruce E. Mackey, Jian Wu, Darshan S. Kelley

Research output: Contribution to journalArticle

2 Scopus citations

Abstract

It has been shown that docosahexaenoic acid (DHA) prevents nonalcoholic fatty liver disease (NAFLD) and insulin resistance (IR) caused by conjugated linoleic acid (CLA), a trans fatty acid (TFA). Here, we evaluated whether DHA will reverse existing CLA-induced NAFLD and IR in mice. DHA-specific effects on existing NAFLD involved significant (P

Original languageEnglish (US)
Pages (from-to)443-452
Number of pages10
JournalJournal of Functional Foods
Volume20
DOIs
StatePublished - Jan 1 2016

Keywords

  • DHA
  • Hepatic steatosis
  • Insulin resistance
  • NAFLD
  • NASH
  • Trans fatty acid

ASJC Scopus subject areas

  • Food Science
  • Medicine (miscellaneous)
  • Nutrition and Dietetics

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