Abstract
This study determined the effect of a commercial dry expanded (complex) diet and purified diet on methotrexate (MTX) toxicity and pharmacokinetics in the cat. Twelve cats were randomized to receive a purified diet or a complex diet for 21 days. They were then given an intravenous bolus injection of MTX at a dose of 10 mg/kg (160 mg/M2). Cats fed the purified diet had severe enteritis, characterized by depression, lethargy, diarrhea, and vomiting. Cats receiving the complex diet remained mentally bright, alert, and responsive throughout the post-chemotherapy period, and only one of six cats in this dietary group developed mild diarrhea 48 hr after MTX administration. Methotrexate was associated with a significant (P < 0.0001) reduction in the total white blood cell (WBC) counts in cats receiving the purified and complex diets. The elimination of MTX appeared to follow a three-compartment model of elimination. Plasma MTX concentrations at all time points examined were virtually identical in cats receiving the purified and complex diets. The terminal half-life of MTX in cats receiving the complex and purified diets was 1.75 ± 0.44 hr and 2.77 ± 0.8 hr, respectively. The similarity of plasma MTX concentrations and pharmacokinetic parameters in both dietary groups suggests that dietary alterations may influence enterotoxicity directly rather than altering exposure to MTX.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 79-84 |
| Number of pages | 6 |
| Journal | Journal of Nutritional Biochemistry |
| Volume | 8 |
| Issue number | 2 |
| DOIs | |
| State | Published - Feb 1997 |
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Keywords
- cat
- enteritis
- feline
- methotrexate pharmacokinetics
- purified diet
ASJC Scopus subject areas
- Biochemistry
- Endocrinology, Diabetes and Metabolism
Cite this
Dietary composition alters methotrexate toxicity without changing its pharmacokinetic parameters in cats. / Marks, Stanley L; Vulliet, Philip R; Kass, Philip H; Rogers, Quinton.
In: Journal of Nutritional Biochemistry, Vol. 8, No. 2, 02.1997, p. 79-84.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Dietary composition alters methotrexate toxicity without changing its pharmacokinetic parameters in cats
AU - Marks, Stanley L
AU - Vulliet, Philip R
AU - Kass, Philip H
AU - Rogers, Quinton
PY - 1997/2
Y1 - 1997/2
N2 - This study determined the effect of a commercial dry expanded (complex) diet and purified diet on methotrexate (MTX) toxicity and pharmacokinetics in the cat. Twelve cats were randomized to receive a purified diet or a complex diet for 21 days. They were then given an intravenous bolus injection of MTX at a dose of 10 mg/kg (160 mg/M2). Cats fed the purified diet had severe enteritis, characterized by depression, lethargy, diarrhea, and vomiting. Cats receiving the complex diet remained mentally bright, alert, and responsive throughout the post-chemotherapy period, and only one of six cats in this dietary group developed mild diarrhea 48 hr after MTX administration. Methotrexate was associated with a significant (P < 0.0001) reduction in the total white blood cell (WBC) counts in cats receiving the purified and complex diets. The elimination of MTX appeared to follow a three-compartment model of elimination. Plasma MTX concentrations at all time points examined were virtually identical in cats receiving the purified and complex diets. The terminal half-life of MTX in cats receiving the complex and purified diets was 1.75 ± 0.44 hr and 2.77 ± 0.8 hr, respectively. The similarity of plasma MTX concentrations and pharmacokinetic parameters in both dietary groups suggests that dietary alterations may influence enterotoxicity directly rather than altering exposure to MTX.
AB - This study determined the effect of a commercial dry expanded (complex) diet and purified diet on methotrexate (MTX) toxicity and pharmacokinetics in the cat. Twelve cats were randomized to receive a purified diet or a complex diet for 21 days. They were then given an intravenous bolus injection of MTX at a dose of 10 mg/kg (160 mg/M2). Cats fed the purified diet had severe enteritis, characterized by depression, lethargy, diarrhea, and vomiting. Cats receiving the complex diet remained mentally bright, alert, and responsive throughout the post-chemotherapy period, and only one of six cats in this dietary group developed mild diarrhea 48 hr after MTX administration. Methotrexate was associated with a significant (P < 0.0001) reduction in the total white blood cell (WBC) counts in cats receiving the purified and complex diets. The elimination of MTX appeared to follow a three-compartment model of elimination. Plasma MTX concentrations at all time points examined were virtually identical in cats receiving the purified and complex diets. The terminal half-life of MTX in cats receiving the complex and purified diets was 1.75 ± 0.44 hr and 2.77 ± 0.8 hr, respectively. The similarity of plasma MTX concentrations and pharmacokinetic parameters in both dietary groups suggests that dietary alterations may influence enterotoxicity directly rather than altering exposure to MTX.
KW - cat
KW - enteritis
KW - feline
KW - methotrexate pharmacokinetics
KW - purified diet
UR - http://www.scopus.com/inward/record.url?scp=0031003558&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0031003558&partnerID=8YFLogxK
U2 - 10.1016/S0955-2863(96)00177-5
DO - 10.1016/S0955-2863(96)00177-5
M3 - Article
VL - 8
SP - 79
EP - 84
JO - Journal of Nutritional Biochemistry
JF - Journal of Nutritional Biochemistry
SN - 0955-2863
IS - 2
ER -