Dietary and anthropometric determinants of plasma lipoproteins during a long-term low-fat diet in healthy women

Siddika E Karakas, Silvana Martino, Paik Nyon Kim, Sheila Khilnani, Allison Boomer, Janice Depper, Bruce A. Reading, Lance K. Heilbrun

Research output: Contribution to journalArticle

84 Scopus citations

Abstract

Long-term (1 y) effects of dietary fat intake on lipoprotein metabolism were determined in 72 healthy women receiving either a 15%-fat diet (n = 34) or usual diet (n = 38). Every three months food records, weight, waist-hip ratio (W:H), percent body fat, fasting plasma triglyceride, cholesterol (C), high-density-lipoprotein cholesterol (HDL-C), HDL2-C, and HDL3-C; apolipoprotein B and A-I, and postheparin lipoprotein lipase (LPL) and hepatic triglyceride lipase activities were determined. In one year, the low-fat-diet (LFD) group had 17% and the nonintervention-diet group had 36% dietary fat. The LFD group showed decreases in cholesterol: 7% TC, 13% low-density lipoprotein (LDL), and 8% HDL. Apolipoprotein A-I, decreased early. Apolipoprotein B did not change. Plasma triglyceride correlated with weight. Percent body fat and W:H correlated with the total and LDL-C. Changes in HDL-C and/or HDL2-C and LPL correlated directly with the changes in dietary fat and inversely with dietary carbohydrate. Changes in total-C or LDL-C correlated with the changes in weight and W:H, but not with the changes in nutrient intake.

Original languageEnglish (US)
Pages (from-to)146-153
Number of pages8
JournalAmerican Journal of Clinical Nutrition
Volume57
Issue number2
StatePublished - Feb 1993

Keywords

  • Lipases
  • Lipoproteins
  • Low-fat diet
  • Nutrients
  • Women

ASJC Scopus subject areas

  • Food Science
  • Medicine (miscellaneous)

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    Karakas, S. E., Martino, S., Kim, P. N., Khilnani, S., Boomer, A., Depper, J., Reading, B. A., & Heilbrun, L. K. (1993). Dietary and anthropometric determinants of plasma lipoproteins during a long-term low-fat diet in healthy women. American Journal of Clinical Nutrition, 57(2), 146-153.