Diet-induced hypercholesterolemia enhances brain Aβ accumulation in transgenic mice

Feng Shiun Shie, Lee-Way Jin, David G. Cook, James B. Leverenz, Renée C. LeBoeuf

Research output: Contribution to journalArticlepeer-review

188 Scopus citations


Epidemiological data show correlations between hypercholesterolemia and Alzheimer's disease (AD). We test the hypothesis that hypercholesterolemia modulates Aβ deposition in mice overexpressing the human APP695 Swedish mutation (K670N and M671L) (TgAPPsw). Feeding mice a high fat/high cholesterol (HFHC) diet for 7-10 months increased total cholesterol levels by 4-fold. The extent of Aβ immunostained plaque-like deposits were significantly higher for mice fed the HFHC diet as compared with mice fed rodent chow. Extent of deposits correlated inversely with plasma levels of HDL and directly to apolipoprotein E. Overall, plasma lipoproteins may be an important factor in induction of AD-like plaques in mice. The lowering of plasma lipids may be therapeutic for AD patients.

Original languageEnglish (US)
Pages (from-to)455-459
Number of pages5
Issue number4
StatePublished - Mar 25 2002
Externally publishedYes


  • Alzheimer's disease
  • Cholesterol
  • Diet
  • Lipoproteins
  • Mice

ASJC Scopus subject areas

  • Neuroscience(all)


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