Abstract
The effect of dietary modifications has been extensively studied in lupus animal models. Calorie, protein, and especially fat restriction, caused a significant reduction in immune-complex deposition in the kidney, reduced proteinuria and prolongation of the mice's life span. The addition of polyunsaturated fatty acids (PUFAs), such as fish oil or linseed oil, was also related to decreased mice morbidity and mortality in animal models of lupus and of antiphospholipid syndrome. PUFAs such as eicosapetaenoic acid (EPA) and docosahexaenoic acid (DHA) competitively inhibit arachidonic acid with a resultant decrease in inflammatory eicosanoids and cytokines. Human studies support the effect of a PUFAs-enriched diet, both scrologically and clinically. Large scale clinical studies are needed to confirm the primary results.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 246-248 |
| Number of pages | 3 |
| Journal | Lupus |
| Volume | 10 |
| Issue number | 3 |
| DOIs | |
| State | Published - 2001 |
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Keywords
- Autoimmune diseases
- Fish oil
- Linseed oil
- Lupus erythematosus
- Polyunsaturated fatty acids (PUFAs)
ASJC Scopus subject areas
- Rheumatology
- Immunology
Cite this
Diet and lupus. / Leiba, A.; Amital, H.; Gershwin, M. Eric; Shoenfeld, Y.
In: Lupus, Vol. 10, No. 3, 2001, p. 246-248.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Diet and lupus
AU - Leiba, A.
AU - Amital, H.
AU - Gershwin, M. Eric
AU - Shoenfeld, Y.
PY - 2001
Y1 - 2001
N2 - The effect of dietary modifications has been extensively studied in lupus animal models. Calorie, protein, and especially fat restriction, caused a significant reduction in immune-complex deposition in the kidney, reduced proteinuria and prolongation of the mice's life span. The addition of polyunsaturated fatty acids (PUFAs), such as fish oil or linseed oil, was also related to decreased mice morbidity and mortality in animal models of lupus and of antiphospholipid syndrome. PUFAs such as eicosapetaenoic acid (EPA) and docosahexaenoic acid (DHA) competitively inhibit arachidonic acid with a resultant decrease in inflammatory eicosanoids and cytokines. Human studies support the effect of a PUFAs-enriched diet, both scrologically and clinically. Large scale clinical studies are needed to confirm the primary results.
AB - The effect of dietary modifications has been extensively studied in lupus animal models. Calorie, protein, and especially fat restriction, caused a significant reduction in immune-complex deposition in the kidney, reduced proteinuria and prolongation of the mice's life span. The addition of polyunsaturated fatty acids (PUFAs), such as fish oil or linseed oil, was also related to decreased mice morbidity and mortality in animal models of lupus and of antiphospholipid syndrome. PUFAs such as eicosapetaenoic acid (EPA) and docosahexaenoic acid (DHA) competitively inhibit arachidonic acid with a resultant decrease in inflammatory eicosanoids and cytokines. Human studies support the effect of a PUFAs-enriched diet, both scrologically and clinically. Large scale clinical studies are needed to confirm the primary results.
KW - Autoimmune diseases
KW - Fish oil
KW - Linseed oil
KW - Lupus erythematosus
KW - Polyunsaturated fatty acids (PUFAs)
UR - http://www.scopus.com/inward/record.url?scp=0035047140&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0035047140&partnerID=8YFLogxK
U2 - 10.1191/096120301674681790
DO - 10.1191/096120301674681790
M3 - Article
C2 - 11315362
AN - SCOPUS:0035047140
VL - 10
SP - 246
EP - 248
JO - Lupus
JF - Lupus
SN - 0961-2033
IS - 3
ER -