Diet and lupus

A. Leiba, H. Amital, M. Eric Gershwin, Y. Shoenfeld

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

The effect of dietary modifications has been extensively studied in lupus animal models. Calorie, protein, and especially fat restriction, caused a significant reduction in immune-complex deposition in the kidney, reduced proteinuria and prolongation of the mice's life span. The addition of polyunsaturated fatty acids (PUFAs), such as fish oil or linseed oil, was also related to decreased mice morbidity and mortality in animal models of lupus and of antiphospholipid syndrome. PUFAs such as eicosapetaenoic acid (EPA) and docosahexaenoic acid (DHA) competitively inhibit arachidonic acid with a resultant decrease in inflammatory eicosanoids and cytokines. Human studies support the effect of a PUFAs-enriched diet, both scrologically and clinically. Large scale clinical studies are needed to confirm the primary results.

Original languageEnglish (US)
Pages (from-to)246-248
Number of pages3
JournalLupus
Volume10
Issue number3
DOIs
StatePublished - 2001

Fingerprint

Unsaturated Fatty Acids
Diet
Animal Models
Linseed Oil
Life Support Care
Diet Therapy
Antiphospholipid Syndrome
Eicosanoids
Docosahexaenoic Acids
Fish Oils
Antigen-Antibody Complex
Proteinuria
Arachidonic Acid
Fats
Cytokines
Morbidity
Kidney
Acids
Mortality
Proteins

Keywords

  • Autoimmune diseases
  • Fish oil
  • Linseed oil
  • Lupus erythematosus
  • Polyunsaturated fatty acids (PUFAs)

ASJC Scopus subject areas

  • Rheumatology
  • Immunology

Cite this

Leiba, A., Amital, H., Gershwin, M. E., & Shoenfeld, Y. (2001). Diet and lupus. Lupus, 10(3), 246-248. https://doi.org/10.1191/096120301674681790

Diet and lupus. / Leiba, A.; Amital, H.; Gershwin, M. Eric; Shoenfeld, Y.

In: Lupus, Vol. 10, No. 3, 2001, p. 246-248.

Research output: Contribution to journalArticle

Leiba, A, Amital, H, Gershwin, ME & Shoenfeld, Y 2001, 'Diet and lupus', Lupus, vol. 10, no. 3, pp. 246-248. https://doi.org/10.1191/096120301674681790
Leiba A, Amital H, Gershwin ME, Shoenfeld Y. Diet and lupus. Lupus. 2001;10(3):246-248. https://doi.org/10.1191/096120301674681790
Leiba, A. ; Amital, H. ; Gershwin, M. Eric ; Shoenfeld, Y. / Diet and lupus. In: Lupus. 2001 ; Vol. 10, No. 3. pp. 246-248.
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