Diet and lupus

A. Leiba; H. Amital; M. Eric Gershwin; Y. Shoenfeld

doi:10.1191/096120301674681790

Diet and lupus

A. Leiba, H. Amital, M. Eric Gershwin, Y. Shoenfeld

Rheumatology, Allergy, and Clinical Immunology

Research output: Contribution to journal › Article › peer-review

22 Scopus citations

Abstract

The effect of dietary modifications has been extensively studied in lupus animal models. Calorie, protein, and especially fat restriction, caused a significant reduction in immune-complex deposition in the kidney, reduced proteinuria and prolongation of the mice's life span. The addition of polyunsaturated fatty acids (PUFAs), such as fish oil or linseed oil, was also related to decreased mice morbidity and mortality in animal models of lupus and of antiphospholipid syndrome. PUFAs such as eicosapetaenoic acid (EPA) and docosahexaenoic acid (DHA) competitively inhibit arachidonic acid with a resultant decrease in inflammatory eicosanoids and cytokines. Human studies support the effect of a PUFAs-enriched diet, both scrologically and clinically. Large scale clinical studies are needed to confirm the primary results.

Original language	English (US)
Pages (from-to)	246-248
Number of pages	3
Journal	Lupus
Volume	10
Issue number	3
DOIs	https://doi.org/10.1191/096120301674681790
State	Published - 2001

Keywords

Autoimmune diseases
Fish oil
Linseed oil
Lupus erythematosus
Polyunsaturated fatty acids (PUFAs)

ASJC Scopus subject areas

Rheumatology
Immunology

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abstract = "The effect of dietary modifications has been extensively studied in lupus animal models. Calorie, protein, and especially fat restriction, caused a significant reduction in immune-complex deposition in the kidney, reduced proteinuria and prolongation of the mice's life span. The addition of polyunsaturated fatty acids (PUFAs), such as fish oil or linseed oil, was also related to decreased mice morbidity and mortality in animal models of lupus and of antiphospholipid syndrome. PUFAs such as eicosapetaenoic acid (EPA) and docosahexaenoic acid (DHA) competitively inhibit arachidonic acid with a resultant decrease in inflammatory eicosanoids and cytokines. Human studies support the effect of a PUFAs-enriched diet, both scrologically and clinically. Large scale clinical studies are needed to confirm the primary results.",

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AU - Leiba, A.

AU - Amital, H.

AU - Gershwin, M. Eric

AU - Shoenfeld, Y.

PY - 2001

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KW - Lupus erythematosus

KW - Polyunsaturated fatty acids (PUFAs)

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Diet and lupus

Abstract

Keywords

ASJC Scopus subject areas

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