Diet and 20-year mortality from coronary heart disease. The Ireland-Boston Diet-Heart Study

L. H. Kushi, R. A. Lew, F. J. Stare, C. R. Ellison, M. el Lozy, G. Bourke, L. Daly, I. Graham, N. Hickey, R. Mulcahy

Research output: Contribution to journalArticle

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Abstract

In a prospective epidemiologic study of 1001 middle-aged men, we examined the relation between dietary information collected approximately 20 years ago and subsequent mortality from coronary heart disease. The men were initially enrolled in three cohorts: one of men born and living in Ireland, another of those born in Ireland who had emigrated to Boston, and the third of those born in the Boston area of Irish immigrants. There were no differences in mortality from coronary heart disease among the three cohorts. In within-population analyses, those who died of coronary heart disease had higher Keys (P = 0.06) and modified Hegsted (P = 0.02) dietary scores than did those who did not (a high score indicates a high intake of saturated fatty acids and cholesterol and a relatively low intake of polyunsaturated fatty acids). These associations were significant (P = 0.03 for the Keys and P = 0.04 for the modified Hegsted scores) after adjustment for other risk factors for coronary heart disease. Fiber intake (P = 0.04) and a vegetable-food score, which rose with increased intake of fiber, vegetable protein, and starch (P = 0.02), were lower among those who died from coronary heart disease, though not significantly so after adjustment for other risk factors. A higher Keys score carried an increased risk of coronary heart disease (relative risk, 1.60), and a higher fiber intake carried a decreased risk (relative risk, 0.57). Overall, these results tend to support the hypothesis that diet is related, albeit weakly, to the development of coronary heart disease.

Original languageEnglish (US)
Pages (from-to)811-818
Number of pages8
JournalNew England Journal of Medicine
Volume312
Issue number13
StatePublished - 1985
Externally publishedYes

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Ireland
Coronary Disease
Diet
Mortality
Vegetable Proteins
Unsaturated Fatty Acids
Vegetables
Starch
Epidemiologic Studies
Fatty Acids
Cholesterol
Prospective Studies
Food
Population

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Kushi, L. H., Lew, R. A., Stare, F. J., Ellison, C. R., el Lozy, M., Bourke, G., ... Mulcahy, R. (1985). Diet and 20-year mortality from coronary heart disease. The Ireland-Boston Diet-Heart Study. New England Journal of Medicine, 312(13), 811-818.

Diet and 20-year mortality from coronary heart disease. The Ireland-Boston Diet-Heart Study. / Kushi, L. H.; Lew, R. A.; Stare, F. J.; Ellison, C. R.; el Lozy, M.; Bourke, G.; Daly, L.; Graham, I.; Hickey, N.; Mulcahy, R.

In: New England Journal of Medicine, Vol. 312, No. 13, 1985, p. 811-818.

Research output: Contribution to journalArticle

Kushi, LH, Lew, RA, Stare, FJ, Ellison, CR, el Lozy, M, Bourke, G, Daly, L, Graham, I, Hickey, N & Mulcahy, R 1985, 'Diet and 20-year mortality from coronary heart disease. The Ireland-Boston Diet-Heart Study', New England Journal of Medicine, vol. 312, no. 13, pp. 811-818.
Kushi LH, Lew RA, Stare FJ, Ellison CR, el Lozy M, Bourke G et al. Diet and 20-year mortality from coronary heart disease. The Ireland-Boston Diet-Heart Study. New England Journal of Medicine. 1985;312(13):811-818.
Kushi, L. H. ; Lew, R. A. ; Stare, F. J. ; Ellison, C. R. ; el Lozy, M. ; Bourke, G. ; Daly, L. ; Graham, I. ; Hickey, N. ; Mulcahy, R. / Diet and 20-year mortality from coronary heart disease. The Ireland-Boston Diet-Heart Study. In: New England Journal of Medicine. 1985 ; Vol. 312, No. 13. pp. 811-818.
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AU - el Lozy, M.

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AU - Daly, L.

AU - Graham, I.

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