Abstract
Mallory bodies (MBs) were induced in hepatic tumors by administration for up to 85 weeks of a diet containing 10 ppm dieldrin to 50 C3H/He and 62 C57BL/6J x C3H/He B6C3F1 male mice. MBs were seen in 15 of 28 (54%) mice which developed benign hepatic tumors and 33 of 45 (73%) mice with hepatocellular carcinoma, but in only 3 of 39 (8%) mice without hepatic tumors. In mice with tumors, the MBs were predominantly confined to tumor tissue and persisted in a carcinoma transplanted into a nude mouse. MBs were not observed, however, in hepatic tumors of 67 C57BL/6J, 49 C3H/He, or 81 B6C3F1 mice given 12 μg diethylnitrosamine i.p. on Days 0, 3, 9, and 15. Thirty-one of 195 control mice of all three strains had hepatic tumors. Only one of the controls had a tumor with an MB, and no MBs were seen in nontumor-bearing livers of control animals. These observations, coupled with the results of a previous study in which MBs were observed in hepatocytes of dieldrin-treated C57Bl/6J mice, indicate that mice treated with dieldrin are a reliable animal model for the study of MBs.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 90-95 |
| Number of pages | 6 |
| Journal | Hepatology |
| Volume | 3 |
| Issue number | 1 |
| State | Published - 1983 |
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Dieldrin-induced Mallory bodies in hepatic tumors of mice of different strains. / Meierhenry, E. F.; Ruebner, B. H.; Gershwin, M. Eric; Hsieh, L. S.; French, S. W.
In: Hepatology, Vol. 3, No. 1, 1983, p. 90-95.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Dieldrin-induced Mallory bodies in hepatic tumors of mice of different strains
AU - Meierhenry, E. F.
AU - Ruebner, B. H.
AU - Gershwin, M. Eric
AU - Hsieh, L. S.
AU - French, S. W.
PY - 1983
Y1 - 1983
N2 - Mallory bodies (MBs) were induced in hepatic tumors by administration for up to 85 weeks of a diet containing 10 ppm dieldrin to 50 C3H/He and 62 C57BL/6J x C3H/He B6C3F1 male mice. MBs were seen in 15 of 28 (54%) mice which developed benign hepatic tumors and 33 of 45 (73%) mice with hepatocellular carcinoma, but in only 3 of 39 (8%) mice without hepatic tumors. In mice with tumors, the MBs were predominantly confined to tumor tissue and persisted in a carcinoma transplanted into a nude mouse. MBs were not observed, however, in hepatic tumors of 67 C57BL/6J, 49 C3H/He, or 81 B6C3F1 mice given 12 μg diethylnitrosamine i.p. on Days 0, 3, 9, and 15. Thirty-one of 195 control mice of all three strains had hepatic tumors. Only one of the controls had a tumor with an MB, and no MBs were seen in nontumor-bearing livers of control animals. These observations, coupled with the results of a previous study in which MBs were observed in hepatocytes of dieldrin-treated C57Bl/6J mice, indicate that mice treated with dieldrin are a reliable animal model for the study of MBs.
AB - Mallory bodies (MBs) were induced in hepatic tumors by administration for up to 85 weeks of a diet containing 10 ppm dieldrin to 50 C3H/He and 62 C57BL/6J x C3H/He B6C3F1 male mice. MBs were seen in 15 of 28 (54%) mice which developed benign hepatic tumors and 33 of 45 (73%) mice with hepatocellular carcinoma, but in only 3 of 39 (8%) mice without hepatic tumors. In mice with tumors, the MBs were predominantly confined to tumor tissue and persisted in a carcinoma transplanted into a nude mouse. MBs were not observed, however, in hepatic tumors of 67 C57BL/6J, 49 C3H/He, or 81 B6C3F1 mice given 12 μg diethylnitrosamine i.p. on Days 0, 3, 9, and 15. Thirty-one of 195 control mice of all three strains had hepatic tumors. Only one of the controls had a tumor with an MB, and no MBs were seen in nontumor-bearing livers of control animals. These observations, coupled with the results of a previous study in which MBs were observed in hepatocytes of dieldrin-treated C57Bl/6J mice, indicate that mice treated with dieldrin are a reliable animal model for the study of MBs.
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UR - http://www.scopus.com/inward/citedby.url?scp=0020675032&partnerID=8YFLogxK
M3 - Article
C2 - 6295910
AN - SCOPUS:0020675032
VL - 3
SP - 90
EP - 95
JO - Hepatology
JF - Hepatology
SN - 0270-9139
IS - 1
ER -