Dieldrin-induced Mallory bodies in hepatic tumors of mice of different strains

E. F. Meierhenry, B. H. Ruebner, M. Eric Gershwin, L. S. Hsieh, S. W. French

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Abstract

Mallory bodies (MBs) were induced in hepatic tumors by administration for up to 85 weeks of a diet containing 10 ppm dieldrin to 50 C3H/He and 62 C57BL/6J x C3H/He B6C3F1 male mice. MBs were seen in 15 of 28 (54%) mice which developed benign hepatic tumors and 33 of 45 (73%) mice with hepatocellular carcinoma, but in only 3 of 39 (8%) mice without hepatic tumors. In mice with tumors, the MBs were predominantly confined to tumor tissue and persisted in a carcinoma transplanted into a nude mouse. MBs were not observed, however, in hepatic tumors of 67 C57BL/6J, 49 C3H/He, or 81 B6C3F1 mice given 12 μg diethylnitrosamine i.p. on Days 0, 3, 9, and 15. Thirty-one of 195 control mice of all three strains had hepatic tumors. Only one of the controls had a tumor with an MB, and no MBs were seen in nontumor-bearing livers of control animals. These observations, coupled with the results of a previous study in which MBs were observed in hepatocytes of dieldrin-treated C57Bl/6J mice, indicate that mice treated with dieldrin are a reliable animal model for the study of MBs.

Original languageEnglish (US)
Pages (from-to)90-95
Number of pages6
JournalHepatology
Volume3
Issue number1
StatePublished - 1983

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Mallory Bodies
Dieldrin
Liver
Neoplasms
Diethylnitrosamine
Nude Mice
Hepatocytes
Hepatocellular Carcinoma
Animal Models

ASJC Scopus subject areas

  • Hepatology

Cite this

Meierhenry, E. F., Ruebner, B. H., Gershwin, M. E., Hsieh, L. S., & French, S. W. (1983). Dieldrin-induced Mallory bodies in hepatic tumors of mice of different strains. Hepatology, 3(1), 90-95.

Dieldrin-induced Mallory bodies in hepatic tumors of mice of different strains. / Meierhenry, E. F.; Ruebner, B. H.; Gershwin, M. Eric; Hsieh, L. S.; French, S. W.

In: Hepatology, Vol. 3, No. 1, 1983, p. 90-95.

Research output: Contribution to journalArticle

Meierhenry, EF, Ruebner, BH, Gershwin, ME, Hsieh, LS & French, SW 1983, 'Dieldrin-induced Mallory bodies in hepatic tumors of mice of different strains', Hepatology, vol. 3, no. 1, pp. 90-95.
Meierhenry EF, Ruebner BH, Gershwin ME, Hsieh LS, French SW. Dieldrin-induced Mallory bodies in hepatic tumors of mice of different strains. Hepatology. 1983;3(1):90-95.
Meierhenry, E. F. ; Ruebner, B. H. ; Gershwin, M. Eric ; Hsieh, L. S. ; French, S. W. / Dieldrin-induced Mallory bodies in hepatic tumors of mice of different strains. In: Hepatology. 1983 ; Vol. 3, No. 1. pp. 90-95.
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