Abstract
Repetitive exposure of rats to dieldrin (5 mg/kg) on alternate days results in a progressive elevation in seizure severity. This effect is attributable to kindling and not to accumulation of dieldrin in the brain since seizure severity increased over the entire 19 day exposure period whereas dieldrin brain concentrations had peaked on or before the fourth administration and brain concentrations in rats given 10 or 15 mg/kg were higher on the first day of exposure than concentrations in rats administered 5 mg/kg at any time. In spite of this, seizure ranks were significantly higher during repetitive exposure to 5 mg/kg. The convulsive threshold concentration of dieldrin in brains of naive rats was 5.15 μg/g, a brain level never attained by rats given 5 mg/kg every other day. Nevertheless, the 5 mg/kg rats did develop severe convulsions and 4 of 10 died during repetitive administration. These data strongly implicate kindling as the basic cause for the progressive increase in seizure response upon repetitive exposure.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 69-74 |
| Number of pages | 6 |
| Journal | Proceedings of the Western Pharmacology Society |
| Volume | VOL. 23 |
| State | Published - 1980 |
Fingerprint
ASJC Scopus subject areas
- Pharmacology
Cite this
Dieldrin induced kindling in the rat. / Bowyer, J. F.; Peterson, S. L.; Joy, R. M.; Stark, L. G.; Albertson, Timothy E; Paule, M. G.
In: Proceedings of the Western Pharmacology Society, Vol. VOL. 23, 1980, p. 69-74.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Dieldrin induced kindling in the rat
AU - Bowyer, J. F.
AU - Peterson, S. L.
AU - Joy, R. M.
AU - Stark, L. G.
AU - Albertson, Timothy E
AU - Paule, M. G.
PY - 1980
Y1 - 1980
N2 - Repetitive exposure of rats to dieldrin (5 mg/kg) on alternate days results in a progressive elevation in seizure severity. This effect is attributable to kindling and not to accumulation of dieldrin in the brain since seizure severity increased over the entire 19 day exposure period whereas dieldrin brain concentrations had peaked on or before the fourth administration and brain concentrations in rats given 10 or 15 mg/kg were higher on the first day of exposure than concentrations in rats administered 5 mg/kg at any time. In spite of this, seizure ranks were significantly higher during repetitive exposure to 5 mg/kg. The convulsive threshold concentration of dieldrin in brains of naive rats was 5.15 μg/g, a brain level never attained by rats given 5 mg/kg every other day. Nevertheless, the 5 mg/kg rats did develop severe convulsions and 4 of 10 died during repetitive administration. These data strongly implicate kindling as the basic cause for the progressive increase in seizure response upon repetitive exposure.
AB - Repetitive exposure of rats to dieldrin (5 mg/kg) on alternate days results in a progressive elevation in seizure severity. This effect is attributable to kindling and not to accumulation of dieldrin in the brain since seizure severity increased over the entire 19 day exposure period whereas dieldrin brain concentrations had peaked on or before the fourth administration and brain concentrations in rats given 10 or 15 mg/kg were higher on the first day of exposure than concentrations in rats administered 5 mg/kg at any time. In spite of this, seizure ranks were significantly higher during repetitive exposure to 5 mg/kg. The convulsive threshold concentration of dieldrin in brains of naive rats was 5.15 μg/g, a brain level never attained by rats given 5 mg/kg every other day. Nevertheless, the 5 mg/kg rats did develop severe convulsions and 4 of 10 died during repetitive administration. These data strongly implicate kindling as the basic cause for the progressive increase in seizure response upon repetitive exposure.
UR - http://www.scopus.com/inward/record.url?scp=0019230885&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0019230885&partnerID=8YFLogxK
M3 - Article
VL - VOL. 23
SP - 69
EP - 74
JO - Proceedings of the Western Pharmacology Society
JF - Proceedings of the Western Pharmacology Society
SN - 0083-8969
ER -