DIC and granulomatous vasculitis in a dog with disseminated histoplasmosis

Chen Gilor, Marcella D. Ridgway, Kuldeep Singh

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Disseminated histoplasmosis and disseminated intravascular coagulopathy were diagnosed in a 7 mo old, female spayed mixed-breed dog. The dog improved transiently with supportive care, but deteriorated shortly after initiation of antifungal therapy. The dog was subsequently euthanized. At necropsy, marked granulomatous vasculitis was identified in all affected organs. The tunicae and laminae of the arteries and arterioles were obscured by epithelioid macrophages and multinucleated giant cells admixed with necrotic material. Intracytoplasmic yeast were present within some of these macrophages. To the authors' knowledge, this is the first reported case of granulomatous vasculitis associated with Histoplasma capsulatum in a dog.

Original languageEnglish (US)
JournalJournal of the American Animal Hospital Association
Volume47
Issue number3
DOIs
StatePublished - May 2011
Externally publishedYes

Fingerprint

histoplasmosis
Histoplasmosis
vasculitis
Dacarbazine
Vasculitis
Dogs
dogs
macrophages
Macrophages
Histoplasma capsulatum
Histoplasma
laminae (animals)
Arterioles
giant cells
Giant Cells
arteries
necropsy
Arteries
Yeasts
yeasts

ASJC Scopus subject areas

  • Small Animals

Cite this

DIC and granulomatous vasculitis in a dog with disseminated histoplasmosis. / Gilor, Chen; Ridgway, Marcella D.; Singh, Kuldeep.

In: Journal of the American Animal Hospital Association, Vol. 47, No. 3, 05.2011.

Research output: Contribution to journalArticle

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