Abstract
Disseminated histoplasmosis and disseminated intravascular coagulopathy were diagnosed in a 7 mo old, female spayed mixed-breed dog. The dog improved transiently with supportive care, but deteriorated shortly after initiation of antifungal therapy. The dog was subsequently euthanized. At necropsy, marked granulomatous vasculitis was identified in all affected organs. The tunicae and laminae of the arteries and arterioles were obscured by epithelioid macrophages and multinucleated giant cells admixed with necrotic material. Intracytoplasmic yeast were present within some of these macrophages. To the authors' knowledge, this is the first reported case of granulomatous vasculitis associated with Histoplasma capsulatum in a dog.
| Original language | English (US) |
|---|---|
| Journal | Journal of the American Animal Hospital Association |
| Volume | 47 |
| Issue number | 3 |
| DOIs | |
| State | Published - May 2011 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Small Animals
Cite this
DIC and granulomatous vasculitis in a dog with disseminated histoplasmosis. / Gilor, Chen; Ridgway, Marcella D.; Singh, Kuldeep.
In: Journal of the American Animal Hospital Association, Vol. 47, No. 3, 05.2011.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - DIC and granulomatous vasculitis in a dog with disseminated histoplasmosis
AU - Gilor, Chen
AU - Ridgway, Marcella D.
AU - Singh, Kuldeep
PY - 2011/5
Y1 - 2011/5
N2 - Disseminated histoplasmosis and disseminated intravascular coagulopathy were diagnosed in a 7 mo old, female spayed mixed-breed dog. The dog improved transiently with supportive care, but deteriorated shortly after initiation of antifungal therapy. The dog was subsequently euthanized. At necropsy, marked granulomatous vasculitis was identified in all affected organs. The tunicae and laminae of the arteries and arterioles were obscured by epithelioid macrophages and multinucleated giant cells admixed with necrotic material. Intracytoplasmic yeast were present within some of these macrophages. To the authors' knowledge, this is the first reported case of granulomatous vasculitis associated with Histoplasma capsulatum in a dog.
AB - Disseminated histoplasmosis and disseminated intravascular coagulopathy were diagnosed in a 7 mo old, female spayed mixed-breed dog. The dog improved transiently with supportive care, but deteriorated shortly after initiation of antifungal therapy. The dog was subsequently euthanized. At necropsy, marked granulomatous vasculitis was identified in all affected organs. The tunicae and laminae of the arteries and arterioles were obscured by epithelioid macrophages and multinucleated giant cells admixed with necrotic material. Intracytoplasmic yeast were present within some of these macrophages. To the authors' knowledge, this is the first reported case of granulomatous vasculitis associated with Histoplasma capsulatum in a dog.
UR - http://www.scopus.com/inward/record.url?scp=79958231047&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=79958231047&partnerID=8YFLogxK
U2 - 10.5326/JAAHA-MS-5510
DO - 10.5326/JAAHA-MS-5510
M3 - Article
C2 - 21531969
AN - SCOPUS:79958231047
VL - 47
JO - Journal of the American Animal Hospital Association
JF - Journal of the American Animal Hospital Association
SN - 0587-2871
IS - 3
ER -