Abstract
Rats were exposed to high-dose intraperitoneal cocaine. Pretreatment with diazepam was found to be highly effective in reducing observed seizures from 90% to 0% and reducing the incidence of death from 85% to 10%. Furthermore, diazepam treatment after cocaine exposure was also effective in decreasing deaths, from 80% to 21%, even when given after the onset of seizures. Although diazepam pretreatment was shown to prevent clinically overt seizures, cortical EEGs in these rats demonstrated a continuum of convulsantlike electrical activity Our study points to the protective effects of diazepam when given before or after cocaine exposure. Together, these data suggest that diazepam has significant efficacy against cocaine intoxication even though it does not totally suppress cocaineinduced cortical EEG seizure activity.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 542-546 |
| Number of pages | 5 |
| Journal | Annals of Emergency Medicine |
| Volume | 18 |
| Issue number | 5 |
| DOIs | |
| State | Published - 1989 |
Fingerprint
Keywords
- cocaine, intoxication, experimental
- diazepam, cocaine intoxication
ASJC Scopus subject areas
- Emergency Medicine
Cite this
Diazepam in the prevention of seizures and death in cocaine-intoxicated rats. / Derlet, Robert W.; Albertson, Timothy E.
In: Annals of Emergency Medicine, Vol. 18, No. 5, 1989, p. 542-546.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Diazepam in the prevention of seizures and death in cocaine-intoxicated rats
AU - Derlet, Robert W.
AU - Albertson, Timothy E
PY - 1989
Y1 - 1989
N2 - Rats were exposed to high-dose intraperitoneal cocaine. Pretreatment with diazepam was found to be highly effective in reducing observed seizures from 90% to 0% and reducing the incidence of death from 85% to 10%. Furthermore, diazepam treatment after cocaine exposure was also effective in decreasing deaths, from 80% to 21%, even when given after the onset of seizures. Although diazepam pretreatment was shown to prevent clinically overt seizures, cortical EEGs in these rats demonstrated a continuum of convulsantlike electrical activity Our study points to the protective effects of diazepam when given before or after cocaine exposure. Together, these data suggest that diazepam has significant efficacy against cocaine intoxication even though it does not totally suppress cocaineinduced cortical EEG seizure activity.
AB - Rats were exposed to high-dose intraperitoneal cocaine. Pretreatment with diazepam was found to be highly effective in reducing observed seizures from 90% to 0% and reducing the incidence of death from 85% to 10%. Furthermore, diazepam treatment after cocaine exposure was also effective in decreasing deaths, from 80% to 21%, even when given after the onset of seizures. Although diazepam pretreatment was shown to prevent clinically overt seizures, cortical EEGs in these rats demonstrated a continuum of convulsantlike electrical activity Our study points to the protective effects of diazepam when given before or after cocaine exposure. Together, these data suggest that diazepam has significant efficacy against cocaine intoxication even though it does not totally suppress cocaineinduced cortical EEG seizure activity.
KW - cocaine, intoxication, experimental
KW - diazepam, cocaine intoxication
UR - http://www.scopus.com/inward/record.url?scp=0024584208&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0024584208&partnerID=8YFLogxK
U2 - 10.1016/S0196-0644(89)80840-6
DO - 10.1016/S0196-0644(89)80840-6
M3 - Article
VL - 18
SP - 542
EP - 546
JO - Annals of Emergency Medicine
JF - Annals of Emergency Medicine
SN - 0196-0644
IS - 5
ER -