Diastereoselective synthesis of cyclopentanoids with hydantoin and isoxazoline substituents

Kyung Ho Park; Marilyn M. Olmstead; Mark J. Kurth

doi:10.1021/jo9714831

Diastereoselective synthesis of cyclopentanoids with hydantoin and isoxazoline substituents

Kyung Ho Park, Marilyn M. Olmstead, Mark J. Kurth

Chemistry

Research output: Contribution to journal › Article › peer-review

30 Scopus citations

Abstract

Exploiting 1,3-dipolar cycloaddition and urea → hydantoin cyclization transformations, novel spiro-[cyclopenta[d]isoxazole-4'5-imidazolindine' heterocycles of generalized structure I have been prepared. The 1-amino-3- cyclopentenecarboxylate precursor II was prepared from a suitably activated/protected derivative of glycine and the bis-alkylating agent cis- 1,4-dichloro-2-butene.

Original language	English (US)
Pages (from-to)	113-117
Number of pages	5
Journal	Journal of Organic Chemistry
Volume	63
Issue number	1
DOIs	https://doi.org/10.1021/jo9714831
State	Published - 1998

ASJC Scopus subject areas

Organic Chemistry

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abstract = "Exploiting 1,3-dipolar cycloaddition and urea → hydantoin cyclization transformations, novel spiro-[cyclopenta[d]isoxazole-4'5-imidazolindine' heterocycles of generalized structure I have been prepared. The 1-amino-3- cyclopentenecarboxylate precursor II was prepared from a suitably activated/protected derivative of glycine and the bis-alkylating agent cis- 1,4-dichloro-2-butene.",

author = "Park, {Kyung Ho} and Olmstead, {Marilyn M.} and Kurth, {Mark J.}",

year = "1998",

doi = "10.1021/jo9714831",

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AU - Olmstead, Marilyn M.

AU - Kurth, Mark J.

PY - 1998

Y1 - 1998

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AB - Exploiting 1,3-dipolar cycloaddition and urea → hydantoin cyclization transformations, novel spiro-[cyclopenta[d]isoxazole-4'5-imidazolindine' heterocycles of generalized structure I have been prepared. The 1-amino-3- cyclopentenecarboxylate precursor II was prepared from a suitably activated/protected derivative of glycine and the bis-alkylating agent cis- 1,4-dichloro-2-butene.

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Diastereoselective synthesis of cyclopentanoids with hydantoin and isoxazoline substituents

Abstract

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