Diastereoselective synthesis of cyclopentanoids with hydantoin and isoxazoline substituents

Kyung Ho Park; Marilyn M. Olmstead; Mark J. Kurth

doi:10.1021/jo9714831

Diastereoselective synthesis of cyclopentanoids with hydantoin and isoxazoline substituents

Kyung Ho Park, Marilyn M. Olmstead, Mark J. Kurth

Chemistry

Research output: Contribution to journal › Article › peer-review

31 Scopus citations

Abstract

Exploiting 1,3-dipolar cycloaddition and urea → hydantoin cyclization transformations, novel spiro-[cyclopenta[d]isoxazole-4'5-imidazolindine' heterocycles of generalized structure I have been prepared. The 1-amino-3- cyclopentenecarboxylate precursor II was prepared from a suitably activated/protected derivative of glycine and the bis-alkylating agent cis- 1,4-dichloro-2-butene.

Original language	English (US)
Pages (from-to)	113-117
Number of pages	5
Journal	Journal of Organic Chemistry
Volume	63
Issue number	1
DOIs	https://doi.org/10.1021/jo9714831
State	Published - 1998

ASJC Scopus subject areas

Organic Chemistry

Access to Document

10.1021/jo9714831

Cite this

@article{6855f7de21954edca601ba19f90f807a,

title = "Diastereoselective synthesis of cyclopentanoids with hydantoin and isoxazoline substituents",

abstract = "Exploiting 1,3-dipolar cycloaddition and urea → hydantoin cyclization transformations, novel spiro-[cyclopenta[d]isoxazole-4'5-imidazolindine' heterocycles of generalized structure I have been prepared. The 1-amino-3- cyclopentenecarboxylate precursor II was prepared from a suitably activated/protected derivative of glycine and the bis-alkylating agent cis- 1,4-dichloro-2-butene.",

author = "Park, {Kyung Ho} and Olmstead, {Marilyn M.} and Kurth, {Mark J.}",

year = "1998",

doi = "10.1021/jo9714831",

language = "English (US)",

volume = "63",

pages = "113--117",

journal = "Journal of Organic Chemistry",

issn = "0022-3263",

publisher = "American Chemical Society",

number = "1",

}

TY - JOUR

T1 - Diastereoselective synthesis of cyclopentanoids with hydantoin and isoxazoline substituents

AU - Park, Kyung Ho

AU - Olmstead, Marilyn M.

AU - Kurth, Mark J.

PY - 1998

Y1 - 1998

N2 - Exploiting 1,3-dipolar cycloaddition and urea → hydantoin cyclization transformations, novel spiro-[cyclopenta[d]isoxazole-4'5-imidazolindine' heterocycles of generalized structure I have been prepared. The 1-amino-3- cyclopentenecarboxylate precursor II was prepared from a suitably activated/protected derivative of glycine and the bis-alkylating agent cis- 1,4-dichloro-2-butene.

AB - Exploiting 1,3-dipolar cycloaddition and urea → hydantoin cyclization transformations, novel spiro-[cyclopenta[d]isoxazole-4'5-imidazolindine' heterocycles of generalized structure I have been prepared. The 1-amino-3- cyclopentenecarboxylate precursor II was prepared from a suitably activated/protected derivative of glycine and the bis-alkylating agent cis- 1,4-dichloro-2-butene.

UR - http://www.scopus.com/inward/record.url?scp=0031907040&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0031907040&partnerID=8YFLogxK

U2 - 10.1021/jo9714831

DO - 10.1021/jo9714831

M3 - Article

AN - SCOPUS:0031907040

VL - 63

SP - 113

EP - 117

JO - Journal of Organic Chemistry

JF - Journal of Organic Chemistry

SN - 0022-3263

IS - 1

ER -

Diastereoselective synthesis of cyclopentanoids with hydantoin and isoxazoline substituents

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this