Diastereoselective synthesis of cyclopentanoids with hydantoin and isoxazoline substituents

Kyung Ho Park, Marilyn M. Olmstead, Mark J. Kurth

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

Exploiting 1,3-dipolar cycloaddition and urea → hydantoin cyclization transformations, novel spiro-[cyclopenta[d]isoxazole-4'5-imidazolindine' heterocycles of generalized structure I have been prepared. The 1-amino-3- cyclopentenecarboxylate precursor II was prepared from a suitably activated/protected derivative of glycine and the bis-alkylating agent cis- 1,4-dichloro-2-butene.

Original languageEnglish (US)
Pages (from-to)113-117
Number of pages5
JournalJournal of Organic Chemistry
Volume63
Issue number1
DOIs
StatePublished - 1998

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Hydantoins
Isoxazoles
Cycloaddition
Alkylating Agents
Cyclization
Glycine
Urea
Derivatives
1,4-dichloro-2-butene

ASJC Scopus subject areas

  • Organic Chemistry

Cite this

Diastereoselective synthesis of cyclopentanoids with hydantoin and isoxazoline substituents. / Park, Kyung Ho; Olmstead, Marilyn M.; Kurth, Mark J.

In: Journal of Organic Chemistry, Vol. 63, No. 1, 1998, p. 113-117.

Research output: Contribution to journalArticle

Park, Kyung Ho ; Olmstead, Marilyn M. ; Kurth, Mark J. / Diastereoselective synthesis of cyclopentanoids with hydantoin and isoxazoline substituents. In: Journal of Organic Chemistry. 1998 ; Vol. 63, No. 1. pp. 113-117.
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