Diastereoselective synthesis of γ-lactams by a one-pot, four-component reaction

Wei Jingqiang, Jared T. Shaw

Research output: Contribution to journalArticle

60 Citations (Scopus)

Abstract

A new one-pot, four-component reaction (4CR) between amines, maleic anhydrides, aldehydes, and thiols has been discovered to form tetra-and pentasubstituted γ-lactams with high diastereoselectivity. Each component is independently variable and employed in equivalent stoichiometry, producing only water as a byproduct.

Original languageEnglish (US)
Pages (from-to)4077-4080
Number of pages4
JournalOrganic Letters
Volume9
Issue number20
DOIs
StatePublished - Sep 27 2007

Fingerprint

Maleic Anhydrides
Lactams
Sulfhydryl Compounds
Aldehydes
Stoichiometry
Amines
Byproducts
Water
anhydrides
synthesis
aldehydes
thiols
stoichiometry
amines
water

ASJC Scopus subject areas

  • Molecular Medicine

Cite this

Diastereoselective synthesis of γ-lactams by a one-pot, four-component reaction. / Jingqiang, Wei; Shaw, Jared T.

In: Organic Letters, Vol. 9, No. 20, 27.09.2007, p. 4077-4080.

Research output: Contribution to journalArticle

Jingqiang, Wei ; Shaw, Jared T. / Diastereoselective synthesis of γ-lactams by a one-pot, four-component reaction. In: Organic Letters. 2007 ; Vol. 9, No. 20. pp. 4077-4080.
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