Diastereoselective synthesis of γ-lactams by a one-pot, four-component reaction

Wei Jingqiang, Jared T. Shaw

Research output: Contribution to journalArticle

60 Scopus citations

Abstract

A new one-pot, four-component reaction (4CR) between amines, maleic anhydrides, aldehydes, and thiols has been discovered to form tetra-and pentasubstituted γ-lactams with high diastereoselectivity. Each component is independently variable and employed in equivalent stoichiometry, producing only water as a byproduct.

Original languageEnglish (US)
Pages (from-to)4077-4080
Number of pages4
JournalOrganic Letters
Volume9
Issue number20
DOIs
StatePublished - Sep 27 2007

ASJC Scopus subject areas

  • Molecular Medicine

Fingerprint Dive into the research topics of 'Diastereoselective synthesis of γ-lactams by a one-pot, four-component reaction'. Together they form a unique fingerprint.

  • Cite this