Diastereoselective synthesis of γ-lactams by a one-pot, four-component reaction

Wei Jingqiang, Jared T. Shaw

Research output: Contribution to journalArticlepeer-review

62 Scopus citations


A new one-pot, four-component reaction (4CR) between amines, maleic anhydrides, aldehydes, and thiols has been discovered to form tetra-and pentasubstituted γ-lactams with high diastereoselectivity. Each component is independently variable and employed in equivalent stoichiometry, producing only water as a byproduct.

Original languageEnglish (US)
Pages (from-to)4077-4080
Number of pages4
JournalOrganic Letters
Issue number20
StatePublished - Sep 27 2007

ASJC Scopus subject areas

  • Molecular Medicine


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