Abstract
A diastereoselective base-catalyzed Mannich reaction of cyclic, enolizable anhydrides and N-sulfonyl imines for the synthesis of δ-lactams is reported. This anhydride Mannich reaction tolerates imines derived from aryl and enolizable aldehydes. A base-catalyzed product epimerization pathway ensures high anti diastereoselectivity in aryl and achiral enolizable imines.
Original language | English (US) |
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Pages (from-to) | 2466-2469 |
Number of pages | 4 |
Journal | Organic Letters |
Volume | 19 |
Issue number | 10 |
DOIs | |
State | Published - May 19 2017 |
ASJC Scopus subject areas
- Biochemistry
- Physical and Theoretical Chemistry
- Organic Chemistry