Diagnostic predictors of complications and survival after renal transplantation in cats

Christopher A. Adin, Clare R. Gregory, Andrew E. Kyles, Larry D Cowgill

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

Objective - To identify preoperative diagnostic results that predict postoperative complications and survival in feline renal-transplant recipients. Study Design - Retrospective clinical study. Animals - Sixty-one feline renal allograft recipients. Methods - Medical records for 61 consecutive cats that underwent renal allograft transplantation between January 1, 1996, and December 1, 1999, were reviewed. Age, diagnosis, body weight, body condition score, preoperative medical treatment, systolic blood pressure, packed cell volume, biochemical parameters at admission and at the time of surgery, postoperative complications, and postoperative survival were recorded. Associations of preoperative data with the occurrence of postoperative complications were determined using logistic regression. Postoperative survival was graphed using a Kaplan-Meier cumulative-survival plot. Associations of covariates with postoperative survival were analyzed using Cox proportional hazards analysis. Results - Two parameters were significantly associated with occurrence of postoperative central nervous system (CNS) disorders: blood urea nitrogen concentration (odds ratio = 1.083; 95% CI = 1.018 to 1.148) and serum creatinine concentration (odds ratio = 1.8; 95% CI = 1.413 to 2.187) at the time of surgery. Postoperative survival 6 months after transplantation was 59%, though 3-year survival remained at 42%. Of all covariates investigated, only recipient age (relative hazard = 1.183; 95% CI = 1.039 to 1.334) was significantly associated with survival. Conclusion and Clinical Relevance - Standard measures of preoperative renal dysfunction do not predict postoperative survival in cats after renal transplantation, although an increase in the degree of preoperative azotemia is associated with an increased risk of CNS disorders after surgery. Increased recipient age is associated with decreased survival after renal transplantation.

Original languageEnglish (US)
Pages (from-to)515-521
Number of pages7
JournalVeterinary Surgery
Volume30
Issue number6
DOIs
StatePublished - Nov 2001

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kidney transplant
Kidney Transplantation
postoperative complications
Cats
cats
allografting
nervous system diseases
Survival
surgery
kidneys
odds ratio
central nervous system
hazard characterization
uremia
medical treatment
systolic blood pressure
urea nitrogen
blood serum
Central Nervous System Diseases
Felidae

ASJC Scopus subject areas

  • veterinary(all)

Cite this

Diagnostic predictors of complications and survival after renal transplantation in cats. / Adin, Christopher A.; Gregory, Clare R.; Kyles, Andrew E.; Cowgill, Larry D.

In: Veterinary Surgery, Vol. 30, No. 6, 11.2001, p. 515-521.

Research output: Contribution to journalArticle

Adin, Christopher A. ; Gregory, Clare R. ; Kyles, Andrew E. ; Cowgill, Larry D. / Diagnostic predictors of complications and survival after renal transplantation in cats. In: Veterinary Surgery. 2001 ; Vol. 30, No. 6. pp. 515-521.
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abstract = "Objective - To identify preoperative diagnostic results that predict postoperative complications and survival in feline renal-transplant recipients. Study Design - Retrospective clinical study. Animals - Sixty-one feline renal allograft recipients. Methods - Medical records for 61 consecutive cats that underwent renal allograft transplantation between January 1, 1996, and December 1, 1999, were reviewed. Age, diagnosis, body weight, body condition score, preoperative medical treatment, systolic blood pressure, packed cell volume, biochemical parameters at admission and at the time of surgery, postoperative complications, and postoperative survival were recorded. Associations of preoperative data with the occurrence of postoperative complications were determined using logistic regression. Postoperative survival was graphed using a Kaplan-Meier cumulative-survival plot. Associations of covariates with postoperative survival were analyzed using Cox proportional hazards analysis. Results - Two parameters were significantly associated with occurrence of postoperative central nervous system (CNS) disorders: blood urea nitrogen concentration (odds ratio = 1.083; 95{\%} CI = 1.018 to 1.148) and serum creatinine concentration (odds ratio = 1.8; 95{\%} CI = 1.413 to 2.187) at the time of surgery. Postoperative survival 6 months after transplantation was 59{\%}, though 3-year survival remained at 42{\%}. Of all covariates investigated, only recipient age (relative hazard = 1.183; 95{\%} CI = 1.039 to 1.334) was significantly associated with survival. Conclusion and Clinical Relevance - Standard measures of preoperative renal dysfunction do not predict postoperative survival in cats after renal transplantation, although an increase in the degree of preoperative azotemia is associated with an increased risk of CNS disorders after surgery. Increased recipient age is associated with decreased survival after renal transplantation.",
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N2 - Objective - To identify preoperative diagnostic results that predict postoperative complications and survival in feline renal-transplant recipients. Study Design - Retrospective clinical study. Animals - Sixty-one feline renal allograft recipients. Methods - Medical records for 61 consecutive cats that underwent renal allograft transplantation between January 1, 1996, and December 1, 1999, were reviewed. Age, diagnosis, body weight, body condition score, preoperative medical treatment, systolic blood pressure, packed cell volume, biochemical parameters at admission and at the time of surgery, postoperative complications, and postoperative survival were recorded. Associations of preoperative data with the occurrence of postoperative complications were determined using logistic regression. Postoperative survival was graphed using a Kaplan-Meier cumulative-survival plot. Associations of covariates with postoperative survival were analyzed using Cox proportional hazards analysis. Results - Two parameters were significantly associated with occurrence of postoperative central nervous system (CNS) disorders: blood urea nitrogen concentration (odds ratio = 1.083; 95% CI = 1.018 to 1.148) and serum creatinine concentration (odds ratio = 1.8; 95% CI = 1.413 to 2.187) at the time of surgery. Postoperative survival 6 months after transplantation was 59%, though 3-year survival remained at 42%. Of all covariates investigated, only recipient age (relative hazard = 1.183; 95% CI = 1.039 to 1.334) was significantly associated with survival. Conclusion and Clinical Relevance - Standard measures of preoperative renal dysfunction do not predict postoperative survival in cats after renal transplantation, although an increase in the degree of preoperative azotemia is associated with an increased risk of CNS disorders after surgery. Increased recipient age is associated with decreased survival after renal transplantation.

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