Diagnostic Performance of a Novel Three-Dimensional Neuroretinal Rim Parameter for Glaucoma Using High-Density Volume Scans

Eric Shieh, Ramon Lee, Christian Que, Vivek Srinivasan, Rong Guo, Regina DeLuna, Sumir Pandit, Huseyin Simavli, Rajini Seevaratnam, Edem Tsikata, Johannes de Boer, Teresa C. Chen

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Purpose To evaluate the diagnostic performance of a 3-dimensional (3D) neuroretinal rim parameter, the minimum distance band (MDB), using optical coherence tomography (OCT) high-density volume scans for open-angle glaucoma. Design Reliability analysis. Methods SETTING: Institutional. STUDY POPULATION: Total of 163 patients (105 glaucoma and 58 healthy subjects). OBSERVATION PROCEDURES: One eye of each patient was included. MDB and retinal nerve fiber layer (RNFL) thickness values were determined for 4 quadrants and 4 sectors using a spectral-domain OCT device. MAIN OUTCOME MEASURES: Area under the receiver operating characteristic curve (AUROC) values, sensitivities, specificities, and positive and negative predictive values. Results The best AUROC values of 3D MDB thickness for glaucoma and early glaucoma were for the overall globe (0.969, 0.952), followed by the inferior quadrant (0.966, 0.949) and inferior-temporal sector (0.966, 0.944), and then followed by the superior-temporal sector (0.964, 0.932) and superior quadrant (0.962, 0.924). All 3D MDB thickness AUROC values were higher than those of 2D RNFL thickness. Pairwise comparisons showed that the diagnostic performance of the 3D MDB parameter was significantly better than 2D RNFL thickness only for the nasal quadrant and inferior-nasal and superior-nasal sectors (P = .023–.049). Combining 3D MDB with 2D RNFL parameters provided significantly better diagnostic performance (AUROC 0.984) than most single MDB parameters and all single RNFL parameters. Conclusions Compared with the 2D RNFL thickness parameter, the 3D MDB neuroretinal rim thickness parameter had uniformly equal or better diagnostic performance for glaucoma in all regions and was significantly better in the nasal region.

Original languageEnglish (US)
Pages (from-to)168-178
Number of pages11
JournalAmerican Journal of Ophthalmology
Volume169
DOIs
StatePublished - Sep 1 2016
Externally publishedYes

Fingerprint

Nerve Fibers
Glaucoma
Nose
ROC Curve
Optical Coherence Tomography
Open Angle Glaucoma
Healthy Volunteers
Observation
Sensitivity and Specificity
Equipment and Supplies

ASJC Scopus subject areas

  • Ophthalmology

Cite this

Diagnostic Performance of a Novel Three-Dimensional Neuroretinal Rim Parameter for Glaucoma Using High-Density Volume Scans. / Shieh, Eric; Lee, Ramon; Que, Christian; Srinivasan, Vivek; Guo, Rong; DeLuna, Regina; Pandit, Sumir; Simavli, Huseyin; Seevaratnam, Rajini; Tsikata, Edem; de Boer, Johannes; Chen, Teresa C.

In: American Journal of Ophthalmology, Vol. 169, 01.09.2016, p. 168-178.

Research output: Contribution to journalArticle

Shieh, E, Lee, R, Que, C, Srinivasan, V, Guo, R, DeLuna, R, Pandit, S, Simavli, H, Seevaratnam, R, Tsikata, E, de Boer, J & Chen, TC 2016, 'Diagnostic Performance of a Novel Three-Dimensional Neuroretinal Rim Parameter for Glaucoma Using High-Density Volume Scans', American Journal of Ophthalmology, vol. 169, pp. 168-178. https://doi.org/10.1016/j.ajo.2016.06.028
Shieh, Eric ; Lee, Ramon ; Que, Christian ; Srinivasan, Vivek ; Guo, Rong ; DeLuna, Regina ; Pandit, Sumir ; Simavli, Huseyin ; Seevaratnam, Rajini ; Tsikata, Edem ; de Boer, Johannes ; Chen, Teresa C. / Diagnostic Performance of a Novel Three-Dimensional Neuroretinal Rim Parameter for Glaucoma Using High-Density Volume Scans. In: American Journal of Ophthalmology. 2016 ; Vol. 169. pp. 168-178.
@article{da702720ec874881adfb83f68a631fbc,
title = "Diagnostic Performance of a Novel Three-Dimensional Neuroretinal Rim Parameter for Glaucoma Using High-Density Volume Scans",
abstract = "Purpose To evaluate the diagnostic performance of a 3-dimensional (3D) neuroretinal rim parameter, the minimum distance band (MDB), using optical coherence tomography (OCT) high-density volume scans for open-angle glaucoma. Design Reliability analysis. Methods SETTING: Institutional. STUDY POPULATION: Total of 163 patients (105 glaucoma and 58 healthy subjects). OBSERVATION PROCEDURES: One eye of each patient was included. MDB and retinal nerve fiber layer (RNFL) thickness values were determined for 4 quadrants and 4 sectors using a spectral-domain OCT device. MAIN OUTCOME MEASURES: Area under the receiver operating characteristic curve (AUROC) values, sensitivities, specificities, and positive and negative predictive values. Results The best AUROC values of 3D MDB thickness for glaucoma and early glaucoma were for the overall globe (0.969, 0.952), followed by the inferior quadrant (0.966, 0.949) and inferior-temporal sector (0.966, 0.944), and then followed by the superior-temporal sector (0.964, 0.932) and superior quadrant (0.962, 0.924). All 3D MDB thickness AUROC values were higher than those of 2D RNFL thickness. Pairwise comparisons showed that the diagnostic performance of the 3D MDB parameter was significantly better than 2D RNFL thickness only for the nasal quadrant and inferior-nasal and superior-nasal sectors (P = .023–.049). Combining 3D MDB with 2D RNFL parameters provided significantly better diagnostic performance (AUROC 0.984) than most single MDB parameters and all single RNFL parameters. Conclusions Compared with the 2D RNFL thickness parameter, the 3D MDB neuroretinal rim thickness parameter had uniformly equal or better diagnostic performance for glaucoma in all regions and was significantly better in the nasal region.",
author = "Eric Shieh and Ramon Lee and Christian Que and Vivek Srinivasan and Rong Guo and Regina DeLuna and Sumir Pandit and Huseyin Simavli and Rajini Seevaratnam and Edem Tsikata and {de Boer}, Johannes and Chen, {Teresa C.}",
year = "2016",
month = "9",
day = "1",
doi = "10.1016/j.ajo.2016.06.028",
language = "English (US)",
volume = "169",
pages = "168--178",
journal = "American Journal of Ophthalmology",
issn = "0002-9394",
publisher = "Elsevier USA",

}

TY - JOUR

T1 - Diagnostic Performance of a Novel Three-Dimensional Neuroretinal Rim Parameter for Glaucoma Using High-Density Volume Scans

AU - Shieh, Eric

AU - Lee, Ramon

AU - Que, Christian

AU - Srinivasan, Vivek

AU - Guo, Rong

AU - DeLuna, Regina

AU - Pandit, Sumir

AU - Simavli, Huseyin

AU - Seevaratnam, Rajini

AU - Tsikata, Edem

AU - de Boer, Johannes

AU - Chen, Teresa C.

PY - 2016/9/1

Y1 - 2016/9/1

N2 - Purpose To evaluate the diagnostic performance of a 3-dimensional (3D) neuroretinal rim parameter, the minimum distance band (MDB), using optical coherence tomography (OCT) high-density volume scans for open-angle glaucoma. Design Reliability analysis. Methods SETTING: Institutional. STUDY POPULATION: Total of 163 patients (105 glaucoma and 58 healthy subjects). OBSERVATION PROCEDURES: One eye of each patient was included. MDB and retinal nerve fiber layer (RNFL) thickness values were determined for 4 quadrants and 4 sectors using a spectral-domain OCT device. MAIN OUTCOME MEASURES: Area under the receiver operating characteristic curve (AUROC) values, sensitivities, specificities, and positive and negative predictive values. Results The best AUROC values of 3D MDB thickness for glaucoma and early glaucoma were for the overall globe (0.969, 0.952), followed by the inferior quadrant (0.966, 0.949) and inferior-temporal sector (0.966, 0.944), and then followed by the superior-temporal sector (0.964, 0.932) and superior quadrant (0.962, 0.924). All 3D MDB thickness AUROC values were higher than those of 2D RNFL thickness. Pairwise comparisons showed that the diagnostic performance of the 3D MDB parameter was significantly better than 2D RNFL thickness only for the nasal quadrant and inferior-nasal and superior-nasal sectors (P = .023–.049). Combining 3D MDB with 2D RNFL parameters provided significantly better diagnostic performance (AUROC 0.984) than most single MDB parameters and all single RNFL parameters. Conclusions Compared with the 2D RNFL thickness parameter, the 3D MDB neuroretinal rim thickness parameter had uniformly equal or better diagnostic performance for glaucoma in all regions and was significantly better in the nasal region.

AB - Purpose To evaluate the diagnostic performance of a 3-dimensional (3D) neuroretinal rim parameter, the minimum distance band (MDB), using optical coherence tomography (OCT) high-density volume scans for open-angle glaucoma. Design Reliability analysis. Methods SETTING: Institutional. STUDY POPULATION: Total of 163 patients (105 glaucoma and 58 healthy subjects). OBSERVATION PROCEDURES: One eye of each patient was included. MDB and retinal nerve fiber layer (RNFL) thickness values were determined for 4 quadrants and 4 sectors using a spectral-domain OCT device. MAIN OUTCOME MEASURES: Area under the receiver operating characteristic curve (AUROC) values, sensitivities, specificities, and positive and negative predictive values. Results The best AUROC values of 3D MDB thickness for glaucoma and early glaucoma were for the overall globe (0.969, 0.952), followed by the inferior quadrant (0.966, 0.949) and inferior-temporal sector (0.966, 0.944), and then followed by the superior-temporal sector (0.964, 0.932) and superior quadrant (0.962, 0.924). All 3D MDB thickness AUROC values were higher than those of 2D RNFL thickness. Pairwise comparisons showed that the diagnostic performance of the 3D MDB parameter was significantly better than 2D RNFL thickness only for the nasal quadrant and inferior-nasal and superior-nasal sectors (P = .023–.049). Combining 3D MDB with 2D RNFL parameters provided significantly better diagnostic performance (AUROC 0.984) than most single MDB parameters and all single RNFL parameters. Conclusions Compared with the 2D RNFL thickness parameter, the 3D MDB neuroretinal rim thickness parameter had uniformly equal or better diagnostic performance for glaucoma in all regions and was significantly better in the nasal region.

UR - http://www.scopus.com/inward/record.url?scp=84980034124&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84980034124&partnerID=8YFLogxK

U2 - 10.1016/j.ajo.2016.06.028

DO - 10.1016/j.ajo.2016.06.028

M3 - Article

C2 - 27349414

AN - SCOPUS:84980034124

VL - 169

SP - 168

EP - 178

JO - American Journal of Ophthalmology

JF - American Journal of Ophthalmology

SN - 0002-9394

ER -