Diagnostic liver immunology

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

The vast majority of liver diseases involve, at least in part, an immunologic reaction either as a primary cause of liver injury or in response to an infectious agent. Primary biliary cirrhosis (PBC) and nonalcoholic steatohepatitis (NASH) are representative of the former while viral hepatitis B and C are typical of the latter. Historically, the diagnosis of a liver disease was based primarily on histology and in large part the types and locations of inflammatory cells within the liver parenchyma. This remains the case for alcoholic liver disease and the now epidemic fatty liver disease. However, increasingly specific liver disease diagnoses are made based upon specific immune responses signified by the presence of specific antibodies and other serologic findings. Currently, genetic tests in liver immunology are limited to HLA class II alleles in autoimmune hepatitis and hereditary hemochromatosis, the latter a result of variants in the HLA class I-like HFE gene resulting in dysregulation of the antimicrobial peptide hepcidin and subsequent iron overload. However, as our understanding of the genetic basis of liver diseases progresses, the use of individualized genetics will likely become increasing important in diagnosing many liver diseases and personalizing their treatments. In this chapter, we will review the common liver diseases with an immunologic basis with an emphasis on the diagnostic tools in current use (Table 4.1).

Original languageEnglish (US)
Title of host publicationLiver Immunology: Principles and Practice
PublisherSpringer International Publishing
Pages45-53
Number of pages9
ISBN (Print)9783319020969, 9783319020952
DOIs
StatePublished - Jan 1 2014

Fingerprint

Allergy and Immunology
Liver Diseases
Liver
Hepcidins
Autoimmune Hepatitis
Alcoholic Liver Diseases
Iron Overload
Hemochromatosis
Biliary Liver Cirrhosis
Fatty Liver
Hepatitis C
Hepatitis B
Histology
Alleles
Peptides
Antibodies
Wounds and Injuries
Genes

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Bowlus, C. (2014). Diagnostic liver immunology. In Liver Immunology: Principles and Practice (pp. 45-53). Springer International Publishing. https://doi.org/10.1007/978-3-319-02096-9_4

Diagnostic liver immunology. / Bowlus, Christopher.

Liver Immunology: Principles and Practice. Springer International Publishing, 2014. p. 45-53.

Research output: Chapter in Book/Report/Conference proceedingChapter

Bowlus, C 2014, Diagnostic liver immunology. in Liver Immunology: Principles and Practice. Springer International Publishing, pp. 45-53. https://doi.org/10.1007/978-3-319-02096-9_4
Bowlus C. Diagnostic liver immunology. In Liver Immunology: Principles and Practice. Springer International Publishing. 2014. p. 45-53 https://doi.org/10.1007/978-3-319-02096-9_4
Bowlus, Christopher. / Diagnostic liver immunology. Liver Immunology: Principles and Practice. Springer International Publishing, 2014. pp. 45-53
@inbook{9305072d32554562adffb9f3d9c63d04,
title = "Diagnostic liver immunology",
abstract = "The vast majority of liver diseases involve, at least in part, an immunologic reaction either as a primary cause of liver injury or in response to an infectious agent. Primary biliary cirrhosis (PBC) and nonalcoholic steatohepatitis (NASH) are representative of the former while viral hepatitis B and C are typical of the latter. Historically, the diagnosis of a liver disease was based primarily on histology and in large part the types and locations of inflammatory cells within the liver parenchyma. This remains the case for alcoholic liver disease and the now epidemic fatty liver disease. However, increasingly specific liver disease diagnoses are made based upon specific immune responses signified by the presence of specific antibodies and other serologic findings. Currently, genetic tests in liver immunology are limited to HLA class II alleles in autoimmune hepatitis and hereditary hemochromatosis, the latter a result of variants in the HLA class I-like HFE gene resulting in dysregulation of the antimicrobial peptide hepcidin and subsequent iron overload. However, as our understanding of the genetic basis of liver diseases progresses, the use of individualized genetics will likely become increasing important in diagnosing many liver diseases and personalizing their treatments. In this chapter, we will review the common liver diseases with an immunologic basis with an emphasis on the diagnostic tools in current use (Table 4.1).",
author = "Christopher Bowlus",
year = "2014",
month = "1",
day = "1",
doi = "10.1007/978-3-319-02096-9_4",
language = "English (US)",
isbn = "9783319020969",
pages = "45--53",
booktitle = "Liver Immunology: Principles and Practice",
publisher = "Springer International Publishing",

}

TY - CHAP

T1 - Diagnostic liver immunology

AU - Bowlus, Christopher

PY - 2014/1/1

Y1 - 2014/1/1

N2 - The vast majority of liver diseases involve, at least in part, an immunologic reaction either as a primary cause of liver injury or in response to an infectious agent. Primary biliary cirrhosis (PBC) and nonalcoholic steatohepatitis (NASH) are representative of the former while viral hepatitis B and C are typical of the latter. Historically, the diagnosis of a liver disease was based primarily on histology and in large part the types and locations of inflammatory cells within the liver parenchyma. This remains the case for alcoholic liver disease and the now epidemic fatty liver disease. However, increasingly specific liver disease diagnoses are made based upon specific immune responses signified by the presence of specific antibodies and other serologic findings. Currently, genetic tests in liver immunology are limited to HLA class II alleles in autoimmune hepatitis and hereditary hemochromatosis, the latter a result of variants in the HLA class I-like HFE gene resulting in dysregulation of the antimicrobial peptide hepcidin and subsequent iron overload. However, as our understanding of the genetic basis of liver diseases progresses, the use of individualized genetics will likely become increasing important in diagnosing many liver diseases and personalizing their treatments. In this chapter, we will review the common liver diseases with an immunologic basis with an emphasis on the diagnostic tools in current use (Table 4.1).

AB - The vast majority of liver diseases involve, at least in part, an immunologic reaction either as a primary cause of liver injury or in response to an infectious agent. Primary biliary cirrhosis (PBC) and nonalcoholic steatohepatitis (NASH) are representative of the former while viral hepatitis B and C are typical of the latter. Historically, the diagnosis of a liver disease was based primarily on histology and in large part the types and locations of inflammatory cells within the liver parenchyma. This remains the case for alcoholic liver disease and the now epidemic fatty liver disease. However, increasingly specific liver disease diagnoses are made based upon specific immune responses signified by the presence of specific antibodies and other serologic findings. Currently, genetic tests in liver immunology are limited to HLA class II alleles in autoimmune hepatitis and hereditary hemochromatosis, the latter a result of variants in the HLA class I-like HFE gene resulting in dysregulation of the antimicrobial peptide hepcidin and subsequent iron overload. However, as our understanding of the genetic basis of liver diseases progresses, the use of individualized genetics will likely become increasing important in diagnosing many liver diseases and personalizing their treatments. In this chapter, we will review the common liver diseases with an immunologic basis with an emphasis on the diagnostic tools in current use (Table 4.1).

UR - http://www.scopus.com/inward/record.url?scp=84955115462&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84955115462&partnerID=8YFLogxK

U2 - 10.1007/978-3-319-02096-9_4

DO - 10.1007/978-3-319-02096-9_4

M3 - Chapter

AN - SCOPUS:84955115462

SN - 9783319020969

SN - 9783319020952

SP - 45

EP - 53

BT - Liver Immunology: Principles and Practice

PB - Springer International Publishing

ER -