Abstract
Health care-and device-associated central nervous system (CNS) infections have a distinct epidemiology, pathophysiology, and microbiology that requirea unique diagnostic approach. Most clinical signs, symptoms, and tests used to diagnose community-acquired CNS infections are insensitive and nonspecific in neurosurgical patients due to postsurgical changes, invasive devices, prior antimicrobial exposure, and underlying CNS disease. The lack of a standardized definition of infectionor diagnostic pathway has added to this challenge. In this review, we summarize theepidemiology, microbiology, and clinical presentation of these infections, discuss theissues with existing microbiologic tests, and give an overview of the current diagnostic approach.
| Original language | English (US) |
|---|---|
| Article number | e00861 |
| Journal | Journal of Clinical Microbiology |
| Volume | 56 |
| Issue number | 11 |
| DOIs | |
| State | Published - Nov 1 2018 |
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Keywords
- Central nervous system infections
- Implanted devices
- Meningitis
- Ventriculitis
ASJC Scopus subject areas
- Microbiology (medical)
Cite this
Diagnostic approach to health care-and device-associated central nervous system infections. / Martin, Ryan; Zimmermann, Lara; Huynh, Mindy; Polage, Christopher R.
In: Journal of Clinical Microbiology, Vol. 56, No. 11, e00861, 01.11.2018.Research output: Contribution to journal › Review article
}
TY - JOUR
T1 - Diagnostic approach to health care-and device-associated central nervous system infections
AU - Martin, Ryan
AU - Zimmermann, Lara
AU - Huynh, Mindy
AU - Polage, Christopher R
PY - 2018/11/1
Y1 - 2018/11/1
N2 - Health care-and device-associated central nervous system (CNS) infections have a distinct epidemiology, pathophysiology, and microbiology that requirea unique diagnostic approach. Most clinical signs, symptoms, and tests used to diagnose community-acquired CNS infections are insensitive and nonspecific in neurosurgical patients due to postsurgical changes, invasive devices, prior antimicrobial exposure, and underlying CNS disease. The lack of a standardized definition of infectionor diagnostic pathway has added to this challenge. In this review, we summarize theepidemiology, microbiology, and clinical presentation of these infections, discuss theissues with existing microbiologic tests, and give an overview of the current diagnostic approach.
AB - Health care-and device-associated central nervous system (CNS) infections have a distinct epidemiology, pathophysiology, and microbiology that requirea unique diagnostic approach. Most clinical signs, symptoms, and tests used to diagnose community-acquired CNS infections are insensitive and nonspecific in neurosurgical patients due to postsurgical changes, invasive devices, prior antimicrobial exposure, and underlying CNS disease. The lack of a standardized definition of infectionor diagnostic pathway has added to this challenge. In this review, we summarize theepidemiology, microbiology, and clinical presentation of these infections, discuss theissues with existing microbiologic tests, and give an overview of the current diagnostic approach.
KW - Central nervous system infections
KW - Implanted devices
KW - Meningitis
KW - Ventriculitis
UR - http://www.scopus.com/inward/record.url?scp=85055618834&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85055618834&partnerID=8YFLogxK
U2 - 10.1128/JCM.00861-18
DO - 10.1128/JCM.00861-18
M3 - Review article
C2 - 30135235
AN - SCOPUS:85055618834
VL - 56
JO - Journal of Clinical Microbiology
JF - Journal of Clinical Microbiology
SN - 0095-1137
IS - 11
M1 - e00861
ER -