Diagnostic accuracy of pre-treatment biopsy for grading soft tissue sarcomas in dogs

J. A. Perry, William T Culp, D. D. Dailey, J. C. Eickhoff, D. A. Kamstock, D. H. Thamm

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Histologic grade is an important prognostic factor for both local recurrence and metastatic potential with canine soft tissue sarcoma (STS). Pre-treatment biopsy with identification of tumour grade may aid in prognostication and determination of surgical margins necessary for local control. The purpose of this study was to evaluate the grading accuracy of various pre-treatment biopsy techniques (wedge, punch, needle-core) for STS in dogs. Medical records of 68 dogs diagnosed with a STS via pre-treatment biopsy and confirmed by excisional biopsy were evaluated. The concordance in grade between excisional and pre-treatment biopsies was 59%. Of the 41% that lacked concordance, 29% of pre-treatment biopsies underestimated and 12% overestimated grade. The method of pre-treatment biopsy did not significantly effect grade concordance. Based on these data, needle-core biopsy appears to be similar in accuracy compared to open biopsy, however, grading determined by pre-treatment biopsy in general should be interpreted with caution.

Original languageEnglish (US)
Pages (from-to)106-113
Number of pages8
JournalVeterinary and Comparative Oncology
Volume12
Issue number2
DOIs
StatePublished - 2014

Fingerprint

sarcoma
Sarcoma
biopsy
pretreatment
Dogs
Biopsy
dogs
Therapeutics
Large-Core Needle Biopsy
tissues
Needles
Medical Records
Canidae
Recurrence
neoplasms

Keywords

  • Biopsy
  • Soft tissue sarcoma
  • Surgical oncology

ASJC Scopus subject areas

  • veterinary(all)
  • Medicine(all)

Cite this

Diagnostic accuracy of pre-treatment biopsy for grading soft tissue sarcomas in dogs. / Perry, J. A.; Culp, William T; Dailey, D. D.; Eickhoff, J. C.; Kamstock, D. A.; Thamm, D. H.

In: Veterinary and Comparative Oncology, Vol. 12, No. 2, 2014, p. 106-113.

Research output: Contribution to journalArticle

Perry, J. A. ; Culp, William T ; Dailey, D. D. ; Eickhoff, J. C. ; Kamstock, D. A. ; Thamm, D. H. / Diagnostic accuracy of pre-treatment biopsy for grading soft tissue sarcomas in dogs. In: Veterinary and Comparative Oncology. 2014 ; Vol. 12, No. 2. pp. 106-113.
@article{094e12d8f7b34416adfec135211f5a1d,
title = "Diagnostic accuracy of pre-treatment biopsy for grading soft tissue sarcomas in dogs",
abstract = "Histologic grade is an important prognostic factor for both local recurrence and metastatic potential with canine soft tissue sarcoma (STS). Pre-treatment biopsy with identification of tumour grade may aid in prognostication and determination of surgical margins necessary for local control. The purpose of this study was to evaluate the grading accuracy of various pre-treatment biopsy techniques (wedge, punch, needle-core) for STS in dogs. Medical records of 68 dogs diagnosed with a STS via pre-treatment biopsy and confirmed by excisional biopsy were evaluated. The concordance in grade between excisional and pre-treatment biopsies was 59{\%}. Of the 41{\%} that lacked concordance, 29{\%} of pre-treatment biopsies underestimated and 12{\%} overestimated grade. The method of pre-treatment biopsy did not significantly effect grade concordance. Based on these data, needle-core biopsy appears to be similar in accuracy compared to open biopsy, however, grading determined by pre-treatment biopsy in general should be interpreted with caution.",
keywords = "Biopsy, Soft tissue sarcoma, Surgical oncology",
author = "Perry, {J. A.} and Culp, {William T} and Dailey, {D. D.} and Eickhoff, {J. C.} and Kamstock, {D. A.} and Thamm, {D. H.}",
year = "2014",
doi = "10.1111/j.1476-5829.2012.00333.x",
language = "English (US)",
volume = "12",
pages = "106--113",
journal = "Veterinary and Comparative Oncology",
issn = "1476-5829",
publisher = "Wiley-Blackwell",
number = "2",

}

TY - JOUR

T1 - Diagnostic accuracy of pre-treatment biopsy for grading soft tissue sarcomas in dogs

AU - Perry, J. A.

AU - Culp, William T

AU - Dailey, D. D.

AU - Eickhoff, J. C.

AU - Kamstock, D. A.

AU - Thamm, D. H.

PY - 2014

Y1 - 2014

N2 - Histologic grade is an important prognostic factor for both local recurrence and metastatic potential with canine soft tissue sarcoma (STS). Pre-treatment biopsy with identification of tumour grade may aid in prognostication and determination of surgical margins necessary for local control. The purpose of this study was to evaluate the grading accuracy of various pre-treatment biopsy techniques (wedge, punch, needle-core) for STS in dogs. Medical records of 68 dogs diagnosed with a STS via pre-treatment biopsy and confirmed by excisional biopsy were evaluated. The concordance in grade between excisional and pre-treatment biopsies was 59%. Of the 41% that lacked concordance, 29% of pre-treatment biopsies underestimated and 12% overestimated grade. The method of pre-treatment biopsy did not significantly effect grade concordance. Based on these data, needle-core biopsy appears to be similar in accuracy compared to open biopsy, however, grading determined by pre-treatment biopsy in general should be interpreted with caution.

AB - Histologic grade is an important prognostic factor for both local recurrence and metastatic potential with canine soft tissue sarcoma (STS). Pre-treatment biopsy with identification of tumour grade may aid in prognostication and determination of surgical margins necessary for local control. The purpose of this study was to evaluate the grading accuracy of various pre-treatment biopsy techniques (wedge, punch, needle-core) for STS in dogs. Medical records of 68 dogs diagnosed with a STS via pre-treatment biopsy and confirmed by excisional biopsy were evaluated. The concordance in grade between excisional and pre-treatment biopsies was 59%. Of the 41% that lacked concordance, 29% of pre-treatment biopsies underestimated and 12% overestimated grade. The method of pre-treatment biopsy did not significantly effect grade concordance. Based on these data, needle-core biopsy appears to be similar in accuracy compared to open biopsy, however, grading determined by pre-treatment biopsy in general should be interpreted with caution.

KW - Biopsy

KW - Soft tissue sarcoma

KW - Surgical oncology

UR - http://www.scopus.com/inward/record.url?scp=84897960974&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84897960974&partnerID=8YFLogxK

U2 - 10.1111/j.1476-5829.2012.00333.x

DO - 10.1111/j.1476-5829.2012.00333.x

M3 - Article

VL - 12

SP - 106

EP - 113

JO - Veterinary and Comparative Oncology

JF - Veterinary and Comparative Oncology

SN - 1476-5829

IS - 2

ER -