Diagnosis of vulnerable atherosclerotic plaques by time-resolved fluorescence spectroscopy and ultrasound imaging

J. A. Jo, Q. Fang, T. Papaioannou, J. H. Qiao, M. C. Fishbein, B. Beseth, A. H. Dorafshar, T. Reil, D. Baker, J. Freischlag, K. K. Shung, L. Sun, Laura Marcu

Research output: Chapter in Book/Report/Conference proceedingConference contribution

4 Citations (Scopus)

Abstract

In this study, time-resolved laser-induced fluorescence spectroscopy (TR-LIFS) and ultrasonography were applied to detect vulnerable (high-risk) atherosclerotic plaque. A total of 813 TR-LIFS measurements were taken from carotid plaques of 65 patients, and subsequently analyzed using the Laguerre deconvolution technique. The investigated spots were classified by histopathology as Thin, Fibrotic, Calcified, Low-Inflamed, Inflamed and Necrotic lesions. Spectral and time-resolved parameters (normalized intensity values and Laguerre expansion coefficients) were extracted from the TR-LIFS data. Feature selection for classification was performed by either analysis of variance (ANOVA) or principal component analysis (PCA). A stepwise linear discriminant analysis algorithm was developed for detecting Inflamed and Necrotic lesion, representing the most vulnerable plaques. These vulnerable plaques were detected with high sensitivity (>80%) and specificity (>90%). Ultrasound (US) imaging was obtained in 4 carotid plaques in addition to TR-LIFS examination. Preliminary results indicate that US provides important structural information of the plaques that could be combined with the compositional information obtained by TR-LIFS, to obtain a more accurate diagnosis of vulnerable atherosclerotic plaque.

Original languageEnglish (US)
Title of host publicationAnnual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings
Pages2663-2666
Number of pages4
DOIs
StatePublished - 2006
Event28th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS'06 - New York, NY, United States
Duration: Aug 30 2006Sep 3 2006

Other

Other28th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS'06
CountryUnited States
CityNew York, NY
Period8/30/069/3/06

Fingerprint

Fluorescence spectroscopy
Ultrasonics
Imaging techniques
Lasers
Ultrasonography
Time and motion study
Discriminant analysis
Deconvolution
Analysis of variance (ANOVA)
Principal component analysis
Feature extraction

Keywords

  • Atherosclerosis
  • Laguerre expansion technique
  • Time-resolved fluorescence spectroscopy

ASJC Scopus subject areas

  • Bioengineering

Cite this

Jo, J. A., Fang, Q., Papaioannou, T., Qiao, J. H., Fishbein, M. C., Beseth, B., ... Marcu, L. (2006). Diagnosis of vulnerable atherosclerotic plaques by time-resolved fluorescence spectroscopy and ultrasound imaging. In Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings (pp. 2663-2666). [4029431] https://doi.org/10.1109/IEMBS.2006.259350

Diagnosis of vulnerable atherosclerotic plaques by time-resolved fluorescence spectroscopy and ultrasound imaging. / Jo, J. A.; Fang, Q.; Papaioannou, T.; Qiao, J. H.; Fishbein, M. C.; Beseth, B.; Dorafshar, A. H.; Reil, T.; Baker, D.; Freischlag, J.; Shung, K. K.; Sun, L.; Marcu, Laura.

Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings. 2006. p. 2663-2666 4029431.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Jo, JA, Fang, Q, Papaioannou, T, Qiao, JH, Fishbein, MC, Beseth, B, Dorafshar, AH, Reil, T, Baker, D, Freischlag, J, Shung, KK, Sun, L & Marcu, L 2006, Diagnosis of vulnerable atherosclerotic plaques by time-resolved fluorescence spectroscopy and ultrasound imaging. in Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings., 4029431, pp. 2663-2666, 28th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS'06, New York, NY, United States, 8/30/06. https://doi.org/10.1109/IEMBS.2006.259350
Jo JA, Fang Q, Papaioannou T, Qiao JH, Fishbein MC, Beseth B et al. Diagnosis of vulnerable atherosclerotic plaques by time-resolved fluorescence spectroscopy and ultrasound imaging. In Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings. 2006. p. 2663-2666. 4029431 https://doi.org/10.1109/IEMBS.2006.259350
Jo, J. A. ; Fang, Q. ; Papaioannou, T. ; Qiao, J. H. ; Fishbein, M. C. ; Beseth, B. ; Dorafshar, A. H. ; Reil, T. ; Baker, D. ; Freischlag, J. ; Shung, K. K. ; Sun, L. ; Marcu, Laura. / Diagnosis of vulnerable atherosclerotic plaques by time-resolved fluorescence spectroscopy and ultrasound imaging. Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings. 2006. pp. 2663-2666
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abstract = "In this study, time-resolved laser-induced fluorescence spectroscopy (TR-LIFS) and ultrasonography were applied to detect vulnerable (high-risk) atherosclerotic plaque. A total of 813 TR-LIFS measurements were taken from carotid plaques of 65 patients, and subsequently analyzed using the Laguerre deconvolution technique. The investigated spots were classified by histopathology as Thin, Fibrotic, Calcified, Low-Inflamed, Inflamed and Necrotic lesions. Spectral and time-resolved parameters (normalized intensity values and Laguerre expansion coefficients) were extracted from the TR-LIFS data. Feature selection for classification was performed by either analysis of variance (ANOVA) or principal component analysis (PCA). A stepwise linear discriminant analysis algorithm was developed for detecting Inflamed and Necrotic lesion, representing the most vulnerable plaques. These vulnerable plaques were detected with high sensitivity (>80{\%}) and specificity (>90{\%}). Ultrasound (US) imaging was obtained in 4 carotid plaques in addition to TR-LIFS examination. Preliminary results indicate that US provides important structural information of the plaques that could be combined with the compositional information obtained by TR-LIFS, to obtain a more accurate diagnosis of vulnerable atherosclerotic plaque.",
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AU - Beseth, B.

AU - Dorafshar, A. H.

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