Abstract
In this study, time-resolved laser-induced fluorescence spectroscopy (TR-LIFS) and ultrasonography were applied to detect vulnerable (high-risk) atherosclerotic plaque. A total of 813 TR-LIFS measurements were taken from carotid plaques of 65 patients, and subsequently analyzed using the Laguerre deconvolution technique. The investigated spots were classified by histopathology as Thin, Fibrotic, Calcified, Low-Inflamed, Inflamed and Necrotic lesions. Spectral and time-resolved parameters (normalized intensity values and Laguerre expansion coefficients) were extracted from the TR-LIFS data. Feature selection for classification was performed by either analysis of variance (ANOVA) or principal component analysis (PCA). A stepwise linear discriminant analysis algorithm was developed for detecting Inflamed and Necrotic lesion, representing the most vulnerable plaques. These vulnerable plaques were detected with high sensitivity (>80%) and specificity (>90%). Ultrasound (US) imaging was obtained in 4 carotid plaques in addition to TR-LIFS examination. Preliminary results indicate that US provides important structural information of the plaques that could be combined with the compositional information obtained by TR-LIFS, to obtain a more accurate diagnosis of vulnerable atherosclerotic plaque.
| Original language | English (US) |
|---|---|
| Title of host publication | Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings |
| Pages | 2663-2666 |
| Number of pages | 4 |
| DOIs | |
| State | Published - 2006 |
| Event | 28th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS'06 - New York, NY, United States Duration: Aug 30 2006 → Sep 3 2006 |
Other
| Other | 28th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS'06 |
|---|---|
| Country | United States |
| City | New York, NY |
| Period | 8/30/06 → 9/3/06 |
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Keywords
- Atherosclerosis
- Laguerre expansion technique
- Time-resolved fluorescence spectroscopy
ASJC Scopus subject areas
- Bioengineering
Cite this
Diagnosis of vulnerable atherosclerotic plaques by time-resolved fluorescence spectroscopy and ultrasound imaging. / Jo, J. A.; Fang, Q.; Papaioannou, T.; Qiao, J. H.; Fishbein, M. C.; Beseth, B.; Dorafshar, A. H.; Reil, T.; Baker, D.; Freischlag, J.; Shung, K. K.; Sun, L.; Marcu, Laura.
Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings. 2006. p. 2663-2666 4029431.Research output: Chapter in Book/Report/Conference proceeding › Conference contribution
}
TY - GEN
T1 - Diagnosis of vulnerable atherosclerotic plaques by time-resolved fluorescence spectroscopy and ultrasound imaging
AU - Jo, J. A.
AU - Fang, Q.
AU - Papaioannou, T.
AU - Qiao, J. H.
AU - Fishbein, M. C.
AU - Beseth, B.
AU - Dorafshar, A. H.
AU - Reil, T.
AU - Baker, D.
AU - Freischlag, J.
AU - Shung, K. K.
AU - Sun, L.
AU - Marcu, Laura
PY - 2006
Y1 - 2006
N2 - In this study, time-resolved laser-induced fluorescence spectroscopy (TR-LIFS) and ultrasonography were applied to detect vulnerable (high-risk) atherosclerotic plaque. A total of 813 TR-LIFS measurements were taken from carotid plaques of 65 patients, and subsequently analyzed using the Laguerre deconvolution technique. The investigated spots were classified by histopathology as Thin, Fibrotic, Calcified, Low-Inflamed, Inflamed and Necrotic lesions. Spectral and time-resolved parameters (normalized intensity values and Laguerre expansion coefficients) were extracted from the TR-LIFS data. Feature selection for classification was performed by either analysis of variance (ANOVA) or principal component analysis (PCA). A stepwise linear discriminant analysis algorithm was developed for detecting Inflamed and Necrotic lesion, representing the most vulnerable plaques. These vulnerable plaques were detected with high sensitivity (>80%) and specificity (>90%). Ultrasound (US) imaging was obtained in 4 carotid plaques in addition to TR-LIFS examination. Preliminary results indicate that US provides important structural information of the plaques that could be combined with the compositional information obtained by TR-LIFS, to obtain a more accurate diagnosis of vulnerable atherosclerotic plaque.
AB - In this study, time-resolved laser-induced fluorescence spectroscopy (TR-LIFS) and ultrasonography were applied to detect vulnerable (high-risk) atherosclerotic plaque. A total of 813 TR-LIFS measurements were taken from carotid plaques of 65 patients, and subsequently analyzed using the Laguerre deconvolution technique. The investigated spots were classified by histopathology as Thin, Fibrotic, Calcified, Low-Inflamed, Inflamed and Necrotic lesions. Spectral and time-resolved parameters (normalized intensity values and Laguerre expansion coefficients) were extracted from the TR-LIFS data. Feature selection for classification was performed by either analysis of variance (ANOVA) or principal component analysis (PCA). A stepwise linear discriminant analysis algorithm was developed for detecting Inflamed and Necrotic lesion, representing the most vulnerable plaques. These vulnerable plaques were detected with high sensitivity (>80%) and specificity (>90%). Ultrasound (US) imaging was obtained in 4 carotid plaques in addition to TR-LIFS examination. Preliminary results indicate that US provides important structural information of the plaques that could be combined with the compositional information obtained by TR-LIFS, to obtain a more accurate diagnosis of vulnerable atherosclerotic plaque.
KW - Atherosclerosis
KW - Laguerre expansion technique
KW - Time-resolved fluorescence spectroscopy
UR - http://www.scopus.com/inward/record.url?scp=34047122297&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=34047122297&partnerID=8YFLogxK
U2 - 10.1109/IEMBS.2006.259350
DO - 10.1109/IEMBS.2006.259350
M3 - Conference contribution
C2 - 17946129
AN - SCOPUS:34047122297
SN - 1424400325
SN - 9781424400324
SP - 2663
EP - 2666
BT - Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings
ER -