Diagnosis of naturally acquired type-I and type-II diabetes mellitus in cats.

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Abstract

After IV administration of 0.5 mg of glucagon/cat, glucose tolerance and insulin secretory response were evaluated in 10 lean cats, 10 obese cats, and 30 cats with diabetes mellitus. Blood samples for glucose and insulin determinations were collected immediately before and at 5, 10, 15, 30, 45, and 60 minutes after IV administration of glucagon. Baseline serum insulin concentration and insulin secretory response were used to classify diabetes mellitus in the 30 cats as type I or type II. Mean (+/- SEM) baseline and 30-minute serum glucose concentrations in obese cats were significantly (P < 0.05) decreased, compared with values in lean cats, but were similar at all other blood sample collection times. Serum glucose concentration in diabetic cats was significantly (P < 0.05) greater than values in obese and lean cats at all blood sample collection times. Two statistically different insulin responses to IV administration of glucagon were seen in diabetic cats. Of the 30 diabetic cats, 23 had minimal insulin secretory response after glucagon administration (ie, serum insulin concentration was at or below sensitivity of the insulin assay). Seven diabetic cats had baseline serum insulin concentration similar to that of obese cats and significantly (P < 0.05) greater than that of lean cats and of the other 23 diabetic cats. In these 7 diabetic cats, serum insulin concentration increased after glucagon administration. Total insulin secretion was not significantly different between these 7 diabetic cats and the lean and obese cats, and was significantly (P < 0.05) greater than total insulin secretion in the other 23 diabetic cats.(ABSTRACT TRUNCATED AT 250 WORDS)

Original languageEnglish (US)
Pages (from-to)463-467
Number of pages5
JournalAmerican Journal of Veterinary Research
Volume54
Issue number3
StatePublished - Mar 1993

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Type 1 Diabetes Mellitus
noninsulin-dependent diabetes mellitus
Type 2 Diabetes Mellitus
Cats
cats
Insulin
insulin
blood serum
glucagon
Glucagon
Serum
intravenous injection
insulin secretion
diabetes mellitus
Glucose
glucose
blood
Diabetes Mellitus
glucose tolerance
insulin resistance

ASJC Scopus subject areas

  • veterinary(all)

Cite this

Diagnosis of naturally acquired type-I and type-II diabetes mellitus in cats. / Kirk, C. A.; Feldman, Edward C; Nelson, Richard W.

In: American Journal of Veterinary Research, Vol. 54, No. 3, 03.1993, p. 463-467.

Research output: Contribution to journalArticle

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