Abstract
A 25 year old, 70 kg female chimpanzee had a 12 year history of intermittent signs of upper respiratory tract allergic disease. In June 1987, she was given Terfenadinea, 60 mg b.i.d., with excellent resolution of symptoms. During her annual physical examination, while maintained under ketamine anesthesia, the chimp was skin tested intradermally for respiratory allergies prevalent in the Sacramento area, and blood was drawn for "in vitro" evaluation. Strong positive skin reactions were obtained against grass, weed and tree antigens mixes, with little reaction to mold and mite allergens. Pollen specific IgG4 levels, as measured by fluorescence allergosorbent test (FAST)b, were elevated, and these data are discussed. The serum IgE results corresponded closely with traditional intradermal skin tests, suggesting the application of the human test (FAST)b to the chimpanzee, and potentially other nonhuman primates. The specificity, convenience, absence of risk of serum testing make it an attractive alternative to intradermal skin tests in nonhuman primates.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 271-276 |
| Number of pages | 6 |
| Journal | Allergologia et Immunopathologia |
| Volume | 17 |
| Issue number | 5 |
| State | Published - Sep 1989 |
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ASJC Scopus subject areas
- Immunology and Allergy
Cite this
Diagnosis of inhalant allergy in a chimpanzee using "in vivo" and "in vitro" tests. / Halpern, G. M.; Gershwin, Laurel J; Gonzales, G.; Fowler, M. E.
In: Allergologia et Immunopathologia, Vol. 17, No. 5, 09.1989, p. 271-276.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Diagnosis of inhalant allergy in a chimpanzee using "in vivo" and "in vitro" tests.
AU - Halpern, G. M.
AU - Gershwin, Laurel J
AU - Gonzales, G.
AU - Fowler, M. E.
PY - 1989/9
Y1 - 1989/9
N2 - A 25 year old, 70 kg female chimpanzee had a 12 year history of intermittent signs of upper respiratory tract allergic disease. In June 1987, she was given Terfenadinea, 60 mg b.i.d., with excellent resolution of symptoms. During her annual physical examination, while maintained under ketamine anesthesia, the chimp was skin tested intradermally for respiratory allergies prevalent in the Sacramento area, and blood was drawn for "in vitro" evaluation. Strong positive skin reactions were obtained against grass, weed and tree antigens mixes, with little reaction to mold and mite allergens. Pollen specific IgG4 levels, as measured by fluorescence allergosorbent test (FAST)b, were elevated, and these data are discussed. The serum IgE results corresponded closely with traditional intradermal skin tests, suggesting the application of the human test (FAST)b to the chimpanzee, and potentially other nonhuman primates. The specificity, convenience, absence of risk of serum testing make it an attractive alternative to intradermal skin tests in nonhuman primates.
AB - A 25 year old, 70 kg female chimpanzee had a 12 year history of intermittent signs of upper respiratory tract allergic disease. In June 1987, she was given Terfenadinea, 60 mg b.i.d., with excellent resolution of symptoms. During her annual physical examination, while maintained under ketamine anesthesia, the chimp was skin tested intradermally for respiratory allergies prevalent in the Sacramento area, and blood was drawn for "in vitro" evaluation. Strong positive skin reactions were obtained against grass, weed and tree antigens mixes, with little reaction to mold and mite allergens. Pollen specific IgG4 levels, as measured by fluorescence allergosorbent test (FAST)b, were elevated, and these data are discussed. The serum IgE results corresponded closely with traditional intradermal skin tests, suggesting the application of the human test (FAST)b to the chimpanzee, and potentially other nonhuman primates. The specificity, convenience, absence of risk of serum testing make it an attractive alternative to intradermal skin tests in nonhuman primates.
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M3 - Article
C2 - 2692450
AN - SCOPUS:0024727147
VL - 17
SP - 271
EP - 276
JO - Allergologia et Immunopathologia
JF - Allergologia et Immunopathologia
SN - 0211-6448
IS - 5
ER -