Abstract
Although methods for measuring colloid clearance rates have been described, they are not commonly used. Rather, most clinicians rely on the relative radiocolloid accumulation in the liver and spleen as estimated by visual inspection of liver scans. This method lacks objectivity, however, and only indirectly reflects the rate of radiocolloid clearance. The authors have developed a noninvasive kinetic technique for measuring radiocolloid clearance by the liver, spleen, and other reticuloendothelial tissues. The clearance rate constants obtained by this technique appear to differentiate among cirrhosis, fatty metamorphosis, hepatitis, and normal function. In normal subjects, the mean clearance rate constants for the liver, spleen, and extrahepatosplenic reticuloendothelial system were 16.0, 1.4, and 3.4 ml/min per 100 ml of plasma, respectively. The mean hepatic clearance rate constant was normal in hepatitis (16.8 ml/min per 100 ml), reduced in cirrhosis (5.7), and slightly reduced in fatty metamorphosis (10.4). Both the hepatic to splenic and the hepatic to extrahepatosplenic ratios of clearance rate constants were reduced in cirrhosis and slightly reduced in fatty metamorphosis and hepatitis. Interestingly, the splenic clearance rate constants were normal in these three diseases.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 449-459 |
| Number of pages | 11 |
| Journal | Journal of Nuclear Medicine |
| Volume | 17 |
| Issue number | 6 |
| State | Published - 1976 |
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ASJC Scopus subject areas
- Radiology Nuclear Medicine and imaging
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Diagnosis of cirrhosis and hepatitis by quantitative hepatic and other reticuloendothelial clearance rates. / DeNardo, S. J.; Bell, G. B.; Denardo, Gerald L; Carretta, R. F.; Scheibe, P. O.; Imperato, T. J.; Jackson, P. E.
In: Journal of Nuclear Medicine, Vol. 17, No. 6, 1976, p. 449-459.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Diagnosis of cirrhosis and hepatitis by quantitative hepatic and other reticuloendothelial clearance rates
AU - DeNardo, S. J.
AU - Bell, G. B.
AU - Denardo, Gerald L
AU - Carretta, R. F.
AU - Scheibe, P. O.
AU - Imperato, T. J.
AU - Jackson, P. E.
PY - 1976
Y1 - 1976
N2 - Although methods for measuring colloid clearance rates have been described, they are not commonly used. Rather, most clinicians rely on the relative radiocolloid accumulation in the liver and spleen as estimated by visual inspection of liver scans. This method lacks objectivity, however, and only indirectly reflects the rate of radiocolloid clearance. The authors have developed a noninvasive kinetic technique for measuring radiocolloid clearance by the liver, spleen, and other reticuloendothelial tissues. The clearance rate constants obtained by this technique appear to differentiate among cirrhosis, fatty metamorphosis, hepatitis, and normal function. In normal subjects, the mean clearance rate constants for the liver, spleen, and extrahepatosplenic reticuloendothelial system were 16.0, 1.4, and 3.4 ml/min per 100 ml of plasma, respectively. The mean hepatic clearance rate constant was normal in hepatitis (16.8 ml/min per 100 ml), reduced in cirrhosis (5.7), and slightly reduced in fatty metamorphosis (10.4). Both the hepatic to splenic and the hepatic to extrahepatosplenic ratios of clearance rate constants were reduced in cirrhosis and slightly reduced in fatty metamorphosis and hepatitis. Interestingly, the splenic clearance rate constants were normal in these three diseases.
AB - Although methods for measuring colloid clearance rates have been described, they are not commonly used. Rather, most clinicians rely on the relative radiocolloid accumulation in the liver and spleen as estimated by visual inspection of liver scans. This method lacks objectivity, however, and only indirectly reflects the rate of radiocolloid clearance. The authors have developed a noninvasive kinetic technique for measuring radiocolloid clearance by the liver, spleen, and other reticuloendothelial tissues. The clearance rate constants obtained by this technique appear to differentiate among cirrhosis, fatty metamorphosis, hepatitis, and normal function. In normal subjects, the mean clearance rate constants for the liver, spleen, and extrahepatosplenic reticuloendothelial system were 16.0, 1.4, and 3.4 ml/min per 100 ml of plasma, respectively. The mean hepatic clearance rate constant was normal in hepatitis (16.8 ml/min per 100 ml), reduced in cirrhosis (5.7), and slightly reduced in fatty metamorphosis (10.4). Both the hepatic to splenic and the hepatic to extrahepatosplenic ratios of clearance rate constants were reduced in cirrhosis and slightly reduced in fatty metamorphosis and hepatitis. Interestingly, the splenic clearance rate constants were normal in these three diseases.
UR - http://www.scopus.com/inward/record.url?scp=0017122460&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0017122460&partnerID=8YFLogxK
M3 - Article
C2 - 1262962
AN - SCOPUS:0017122460
VL - 17
SP - 449
EP - 459
JO - Journal of Nuclear Medicine
JF - Journal of Nuclear Medicine
SN - 0161-5505
IS - 6
ER -