Diagnosis of Amanita Toxicosis in a Dog with Acute Hepatic Necrosis

Birgit Puschner, Heidi H. Rose, Michael S. Filigenzi

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

Poisoning with amanitin-containing hepatotoxic mushrooms demands extensive efforts from clinicians, toxicologists, and pathologists. Presumptive diagnoses are established by positive identification of the suspect mushroom along with the occurrence of consistent clinical signs. If the animal dies, hepatic lesions may suggest exposure to amanitin-containing mushrooms; however, lesions are nonspecific. A 15-week-old female Dachshund was presented to the referring veterinarian for acute onset of lethargy that quickly progressed to sternal recumbency. Despite supportive care, the dog remained lethargic and died approximately 12 hours after initial presentation. A pale tan liver was noted at necropsy. Microscopically, the liver showed panlobular coagulative necrosis of hepatocytes. A presumptive diagnosis of amanitin poisoning was based on suspect history of exposure to mushrooms, clinical signs, and pathologic findings. Exposure to amanitin was confirmed through detection of α-amanitin in the liver by liquid chromatography/mass spectrometry. The objective of this case report is to illustrate the essential components to a successful diagnostic work-up of a suspect case of hepatotoxic mushroom poisoning. Although hepatotoxic mushroom poisoning has been documented in dogs before, confirmatory techniques for biologic specimens have not been used previously in diagnostic investigations.

Original languageEnglish (US)
Pages (from-to)312-317
Number of pages6
JournalJournal of Veterinary Diagnostic Investigation
Volume19
Issue number3
DOIs
StatePublished - 2007

Fingerprint

amanitins
Amanita
Amanitins
Agaricales
poisoning
necrosis
Necrosis
mushrooms
Dogs
mushroom poisoning
Mushroom Poisoning
liver
dogs
Liver
lesions (animal)
Poisoning
Dachshund
Lethargy
Veterinarians
Liquid Chromatography

Keywords

  • Amanita
  • amanitins
  • analysis
  • dog
  • hepatotoxic
  • pathology
  • toxicosis

ASJC Scopus subject areas

  • veterinary(all)
  • Microbiology

Cite this

Diagnosis of Amanita Toxicosis in a Dog with Acute Hepatic Necrosis. / Puschner, Birgit; Rose, Heidi H.; Filigenzi, Michael S.

In: Journal of Veterinary Diagnostic Investigation, Vol. 19, No. 3, 2007, p. 312-317.

Research output: Contribution to journalArticle

Puschner, Birgit ; Rose, Heidi H. ; Filigenzi, Michael S. / Diagnosis of Amanita Toxicosis in a Dog with Acute Hepatic Necrosis. In: Journal of Veterinary Diagnostic Investigation. 2007 ; Vol. 19, No. 3. pp. 312-317.
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