Diagnosis and classification of autoimmune hemolytic anemia

Garrett F. Bass, Emily T. Tuscano, Joseph Tuscano

Research output: Contribution to journalArticle

50 Citations (Scopus)

Abstract

Uncompensated autoantibody-mediated red blood cell (RBC) consumption is the hallmark of autoimmune hemolytic anemia (AIHA). Classification of AIHA is pathophysiologically based and divides AIHA into warm, mixed or cold-reactive subtypes. This thermal-based classification is based on the optimal autoantibody-RBC reactivity temperatures. AIHA is further subcategorized into idiopathic and secondary with the later being associated with a number of underlying infectious, neoplastic and autoimmune disorders. In most cases AIHA is confirmed by a positive direct antiglobulin test (DAT). The standard therapeutic approaches to treatment of AIHA include corticosteroids, splenectomy, immunosuppressive agents and monoclonal antibodies.

Original languageEnglish (US)
Pages (from-to)560-564
Number of pages5
JournalAutoimmunity Reviews
Volume13
Issue number4-5
DOIs
StatePublished - 2014

Fingerprint

Autoimmune Hemolytic Anemia
Autoantibodies
Erythrocytes
Coombs Test
Splenectomy
Immunosuppressive Agents
Adrenal Cortex Hormones
Hot Temperature
Monoclonal Antibodies
Temperature

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy

Cite this

Diagnosis and classification of autoimmune hemolytic anemia. / Bass, Garrett F.; Tuscano, Emily T.; Tuscano, Joseph.

In: Autoimmunity Reviews, Vol. 13, No. 4-5, 2014, p. 560-564.

Research output: Contribution to journalArticle

Bass, Garrett F. ; Tuscano, Emily T. ; Tuscano, Joseph. / Diagnosis and classification of autoimmune hemolytic anemia. In: Autoimmunity Reviews. 2014 ; Vol. 13, No. 4-5. pp. 560-564.
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