Diagnosis and classification of autoimmune hemolytic anemia

Garrett F. Bass, Emily T. Tuscano, Joseph Tuscano

Research output: Contribution to journalArticle

59 Scopus citations

Abstract

Uncompensated autoantibody-mediated red blood cell (RBC) consumption is the hallmark of autoimmune hemolytic anemia (AIHA). Classification of AIHA is pathophysiologically based and divides AIHA into warm, mixed or cold-reactive subtypes. This thermal-based classification is based on the optimal autoantibody-RBC reactivity temperatures. AIHA is further subcategorized into idiopathic and secondary with the later being associated with a number of underlying infectious, neoplastic and autoimmune disorders. In most cases AIHA is confirmed by a positive direct antiglobulin test (DAT). The standard therapeutic approaches to treatment of AIHA include corticosteroids, splenectomy, immunosuppressive agents and monoclonal antibodies.

Original languageEnglish (US)
Pages (from-to)560-564
Number of pages5
JournalAutoimmunity Reviews
Volume13
Issue number4-5
DOIs
StatePublished - 2014

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy

Fingerprint Dive into the research topics of 'Diagnosis and classification of autoimmune hemolytic anemia'. Together they form a unique fingerprint.

  • Cite this