Diabetes is a proinflammatory state: A translational perspective

Sridevi Devaraj, Mohan R. Dasu, Ishwarlal Jialal

Research output: Contribution to journalArticle

81 Scopus citations

Abstract

The diabetic state confers an increased propensity to accelerated atherogenesis. Inflammation is pivotal in atherosclerosis; in addition to the established risk factors, inflammation appears to play a pivotal role in diabetes and its complications. Evidence for increased inflammation includes: increased levels of plasma C-reactive protein, the prototypic marker of inflammation; increased levels of plasminogen-activator inhibitor; increased monocyte superoxide and proinflammatory cytokine release (IL-1, IL-6 and TNF-α); increased monocyte adhesion to endothelium; increased NF-B activity; and increased Toll-like receptor 2 and 4 expression and activity in diabetes. Thus, it appears that both Type 1 and Type 2 diabetes are proinflammatory states and that these could contribute to increased diabetic vasculopathies.

Original languageEnglish (US)
Pages (from-to)19-28
Number of pages10
JournalExpert Review of Endocrinology and Metabolism
Volume5
Issue number1
DOIs
StatePublished - Jan 2010

Keywords

  • Atherosclerosis
  • C-reactive protein
  • Diabetes
  • Inflammation
  • Toll-like receptor

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism

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