Diabetes and endometrial cancer in the Iowa Women's Health Study

K. E. Anderson, E. Anderson, P. J. Mink, Ping Hong Ching Ping Hong, L. H. Kushi, T. A. Sellers, D. Lazovich, A. R. Folsom

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110 Scopus citations

Abstract

Diabetes has been associated with increased risk of endometrial cancer in some epidemiological studies. Body mass index (BMI) and other measures of obesity have been associated positively with both diabetes and endometrial cancer. It is not clear whether or not the association of diabetes with endometrial cancer is explained entirely by obesity. Thus, we sought to test the hypothesis that diabetes is not associated with endometrial cancer independent of obesity. We examined the association between self-reported diabetes (onset at >30 years of age) and incident endometrial cancer in a prospective cohort study of 24,664 postmenopausal women in Iowa. Over 12 years of follow-up, 346 cases occurred among the cohort at risk. Data were analyzed using proportional hazards regression models. Diabetes was analyzed as reported at baseline and as a time-dependent variable using information obtained during follow-up. After adjustment for BMI, waist:hip ratio, and other covariates, the relative risk (RR) for women with diabetes versus women without diabetes was 1.43 [95% confidence interval (CI), 0.98-2.1]. The diabetes association was confined to women in the upper two BMI quintiles (RR, 1.47; 95% CI, 0.98-2.20), but a formal test of interaction was not statistically significant. Analyses that included diabetes ascertained at baseline and at follow-up gave similar results; the diabetes-associated RR in the higher BMI strata was 1.64 (95% CI, 1.16-2.31). We conclude that after adjustment for other risk factors, diabetes is associated with a modestly increased risk for endometrial cancer among women in this cohort.

Original languageEnglish (US)
Pages (from-to)611-616
Number of pages6
JournalCancer Epidemiology Biomarkers and Prevention
Volume10
Issue number6
StatePublished - 2001
Externally publishedYes

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ASJC Scopus subject areas

  • Epidemiology
  • Oncology

Cite this

Anderson, K. E., Anderson, E., Mink, P. J., Ching Ping Hong, P. H., Kushi, L. H., Sellers, T. A., Lazovich, D., & Folsom, A. R. (2001). Diabetes and endometrial cancer in the Iowa Women's Health Study. Cancer Epidemiology Biomarkers and Prevention, 10(6), 611-616.