Diabetes and cognition

Elizabeth Rose Mayeda, Rachel Whitmer, Kristine Yaffe

Research output: Contribution to journalReview article

42 Scopus citations

Abstract

Dementia is a major cause of disability and death among older adults. Those with type 2 diabetes (T2D) are 50-100% more likely to develop dementia than those without T2D, but it is unknown whether this association reflects a causal relationship. Proposed mechanisms through which T2D could cause dementia include the effects of insulin dysregulation and chronic hyperglycemia on features of Alzheimer's disease and macrovascular and microvascular disorders in the brain. More research is needed to elucidate the link between T2D and dementia and identify strategies to maintain cognitive function among people with T2D.

Original languageEnglish (US)
Pages (from-to)101-115
Number of pages15
JournalClinics in Geriatric Medicine
Volume31
Issue number1
DOIs
StatePublished - Jan 1 2015
Externally publishedYes

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Keywords

  • Aging
  • Cognition
  • Cognitive decline
  • Dementia
  • Epidemiology
  • Type 2 diabetes

ASJC Scopus subject areas

  • Geriatrics and Gerontology

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