Dexamethasone inhibition of the development of dysplastic bony lesions in LP/J mice

Hilary A Brodie, P. S. Chang, R. A. Chole

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Inbred LP/J mice have been observed to spontaneously develop abnormal bony lesions of the ossicles and otic capsule that progress throughout the life of the animals. This genetically inherited murine disorder produces bony lesions that share some gross and histologic features with bony lesions seen in human tympanosclerosis. Previous studies on LP/J mice have demonstrated evidence of immunologically mediated injury in the progression of the newly forming bony lesions. This study was designed to examine the effects of dexamethasone on the development of the bony lesions in LP/J mice. The purpose was to attempt to elucidate the relationship of the immunologic injury observed in earlier studies and the progression of the dysplastic bony lesions. The results show that LP/J mice treated with dexamethasone developed significantly fewer dysplastic bony lesions compared to the age-matched, saline-treated controls. There was also a statistically significant difference in the quantity and cellularity of the middle ear effusions between the experimental and control animals.

Original languageEnglish (US)
Pages (from-to)814-817
Number of pages4
JournalAnnals of Otology, Rhinology and Laryngology
Volume102
Issue number10
StatePublished - 1993

Fingerprint

Dexamethasone
Myringosclerosis
Otitis Media with Effusion
Wounds and Injuries
Capsules
Ear

Keywords

  • dexamethasone
  • ear disease
  • inbred strain mice
  • temporal bone
  • tympanosclerosis

ASJC Scopus subject areas

  • Otorhinolaryngology

Cite this

Dexamethasone inhibition of the development of dysplastic bony lesions in LP/J mice. / Brodie, Hilary A; Chang, P. S.; Chole, R. A.

In: Annals of Otology, Rhinology and Laryngology, Vol. 102, No. 10, 1993, p. 814-817.

Research output: Contribution to journalArticle

@article{7af29c2e14794d11944769bf93771382,
title = "Dexamethasone inhibition of the development of dysplastic bony lesions in LP/J mice",
abstract = "Inbred LP/J mice have been observed to spontaneously develop abnormal bony lesions of the ossicles and otic capsule that progress throughout the life of the animals. This genetically inherited murine disorder produces bony lesions that share some gross and histologic features with bony lesions seen in human tympanosclerosis. Previous studies on LP/J mice have demonstrated evidence of immunologically mediated injury in the progression of the newly forming bony lesions. This study was designed to examine the effects of dexamethasone on the development of the bony lesions in LP/J mice. The purpose was to attempt to elucidate the relationship of the immunologic injury observed in earlier studies and the progression of the dysplastic bony lesions. The results show that LP/J mice treated with dexamethasone developed significantly fewer dysplastic bony lesions compared to the age-matched, saline-treated controls. There was also a statistically significant difference in the quantity and cellularity of the middle ear effusions between the experimental and control animals.",
keywords = "dexamethasone, ear disease, inbred strain mice, temporal bone, tympanosclerosis",
author = "Brodie, {Hilary A} and Chang, {P. S.} and Chole, {R. A.}",
year = "1993",
language = "English (US)",
volume = "102",
pages = "814--817",
journal = "Annals of Otology, Rhinology and Laryngology",
issn = "0003-4894",
publisher = "Annals Publishing Company",
number = "10",

}

TY - JOUR

T1 - Dexamethasone inhibition of the development of dysplastic bony lesions in LP/J mice

AU - Brodie, Hilary A

AU - Chang, P. S.

AU - Chole, R. A.

PY - 1993

Y1 - 1993

N2 - Inbred LP/J mice have been observed to spontaneously develop abnormal bony lesions of the ossicles and otic capsule that progress throughout the life of the animals. This genetically inherited murine disorder produces bony lesions that share some gross and histologic features with bony lesions seen in human tympanosclerosis. Previous studies on LP/J mice have demonstrated evidence of immunologically mediated injury in the progression of the newly forming bony lesions. This study was designed to examine the effects of dexamethasone on the development of the bony lesions in LP/J mice. The purpose was to attempt to elucidate the relationship of the immunologic injury observed in earlier studies and the progression of the dysplastic bony lesions. The results show that LP/J mice treated with dexamethasone developed significantly fewer dysplastic bony lesions compared to the age-matched, saline-treated controls. There was also a statistically significant difference in the quantity and cellularity of the middle ear effusions between the experimental and control animals.

AB - Inbred LP/J mice have been observed to spontaneously develop abnormal bony lesions of the ossicles and otic capsule that progress throughout the life of the animals. This genetically inherited murine disorder produces bony lesions that share some gross and histologic features with bony lesions seen in human tympanosclerosis. Previous studies on LP/J mice have demonstrated evidence of immunologically mediated injury in the progression of the newly forming bony lesions. This study was designed to examine the effects of dexamethasone on the development of the bony lesions in LP/J mice. The purpose was to attempt to elucidate the relationship of the immunologic injury observed in earlier studies and the progression of the dysplastic bony lesions. The results show that LP/J mice treated with dexamethasone developed significantly fewer dysplastic bony lesions compared to the age-matched, saline-treated controls. There was also a statistically significant difference in the quantity and cellularity of the middle ear effusions between the experimental and control animals.

KW - dexamethasone

KW - ear disease

KW - inbred strain mice

KW - temporal bone

KW - tympanosclerosis

UR - http://www.scopus.com/inward/record.url?scp=0027521285&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0027521285&partnerID=8YFLogxK

M3 - Article

C2 - 8215105

AN - SCOPUS:0027521285

VL - 102

SP - 814

EP - 817

JO - Annals of Otology, Rhinology and Laryngology

JF - Annals of Otology, Rhinology and Laryngology

SN - 0003-4894

IS - 10

ER -