Abstract
In a clinical study in which patients with alcoholic hepatitis were treated with prednisone for 1 month, posttreatment liver biopsies showed diminished inflammation, but Mallory bodies were not diminished. This suggested that steroid treatment may reduce inflammation by inhibiting NFκB activation. Sparing of Mallory bodies suggests that NFκB activation may not be involved mechanistically in Mallory body formation. To test this idea, we induced Mallory body formation in drag-primed mice with or without dexamethasone treatment. As predicted, dexamethasone decreased NFκB activation; however, Mallory body formation was increased. Surprisingly, TNFα and iNOS, which normally increase as a result of NFκB activation, were upregulated by the dexamethasone treatment. It was concluded that NFκB activation is not involved in Mallory body formation. Despite this, induced increases in TNFα, iNOS, c-jun/API and c-myc expression indicate that oxidative stress is likely involved in Mallory body formation. (C) 2000 Academic Press.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 202-210 |
| Number of pages | 9 |
| Journal | Experimental and Molecular Pathology |
| Volume | 69 |
| Issue number | 3 |
| DOIs | |
| State | Published - 2000 |
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ASJC Scopus subject areas
- Clinical Biochemistry
- Molecular Biology
- Pathology and Forensic Medicine
Cite this
Dexamethasone enhances mallory body formation in drug-primed mouse liver. / Yuan, Qi X.; Nagao, Yasuyuki; French, Barbara A.; Wan, Yu-Jui Yvonne; French, Samuel W.
In: Experimental and Molecular Pathology, Vol. 69, No. 3, 2000, p. 202-210.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Dexamethasone enhances mallory body formation in drug-primed mouse liver
AU - Yuan, Qi X.
AU - Nagao, Yasuyuki
AU - French, Barbara A.
AU - Wan, Yu-Jui Yvonne
AU - French, Samuel W.
PY - 2000
Y1 - 2000
N2 - In a clinical study in which patients with alcoholic hepatitis were treated with prednisone for 1 month, posttreatment liver biopsies showed diminished inflammation, but Mallory bodies were not diminished. This suggested that steroid treatment may reduce inflammation by inhibiting NFκB activation. Sparing of Mallory bodies suggests that NFκB activation may not be involved mechanistically in Mallory body formation. To test this idea, we induced Mallory body formation in drag-primed mice with or without dexamethasone treatment. As predicted, dexamethasone decreased NFκB activation; however, Mallory body formation was increased. Surprisingly, TNFα and iNOS, which normally increase as a result of NFκB activation, were upregulated by the dexamethasone treatment. It was concluded that NFκB activation is not involved in Mallory body formation. Despite this, induced increases in TNFα, iNOS, c-jun/API and c-myc expression indicate that oxidative stress is likely involved in Mallory body formation. (C) 2000 Academic Press.
AB - In a clinical study in which patients with alcoholic hepatitis were treated with prednisone for 1 month, posttreatment liver biopsies showed diminished inflammation, but Mallory bodies were not diminished. This suggested that steroid treatment may reduce inflammation by inhibiting NFκB activation. Sparing of Mallory bodies suggests that NFκB activation may not be involved mechanistically in Mallory body formation. To test this idea, we induced Mallory body formation in drag-primed mice with or without dexamethasone treatment. As predicted, dexamethasone decreased NFκB activation; however, Mallory body formation was increased. Surprisingly, TNFα and iNOS, which normally increase as a result of NFκB activation, were upregulated by the dexamethasone treatment. It was concluded that NFκB activation is not involved in Mallory body formation. Despite this, induced increases in TNFα, iNOS, c-jun/API and c-myc expression indicate that oxidative stress is likely involved in Mallory body formation. (C) 2000 Academic Press.
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U2 - 10.1006/exmp.2000.2320
DO - 10.1006/exmp.2000.2320
M3 - Article
VL - 69
SP - 202
EP - 210
JO - Experimental and Molecular Pathology
JF - Experimental and Molecular Pathology
SN - 0014-4800
IS - 3
ER -