Dexamethasone decreases neurological sequelae and caspase activity

Jose Irazuzta, Robert K. Pretzlaff, Gabrielle DeCourten-Myers, Frank Zemlan, Basilia Zingarelli

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

Objective: To evaluate the use of dexamethasone in a model of meningitis-induced brain injury. Changes in neurobehavioral performance were the primary outcome variables. Changes in caspase activation and markers of neuronal injury were the secondary outcome variables. Design: Randomized, prospective animal study. Setting: University research laboratory. Subjects: Male Wistar rats. Interventions: Animals underwent a basilar cistern injection of either placebo or a suspension of Group B Streptococcus. Sixteen hours after inoculation, animals were randomized and received either dexamethasone or placebo in addition to antibiotics. Neurobehavioral performance and biological markers of brain injury were assessed at 3 days and 9 days after randomization. In a second experiment, caspase 1 and 3 were evaluated at 6 h, 24 h, and 72 h after dexamethasone administration. Measurements and main results: Neurobehavioral performance at 3 days and 9 days was significantly improved in the dexamethasone group. Serum C-tau and cerebral edema were decreased after 3 days of dexamethasone treatment. Dexamethasone decreased Caspase 3 ac-tivation in meningitic animals. Conclusion: These findings demonstrate that dexamethasone decreases acute brain injury in a rat model of bacterial meningitis as measured by preservation of neurobehavioral performance.

Original languageEnglish (US)
Pages (from-to)146-150
Number of pages5
JournalIntensive Care Medicine
Volume31
Issue number1
DOIs
StatePublished - Jan 2005

Fingerprint

Caspases
Dexamethasone
Brain Injuries
Caspase 3
Placebos
Caspase 1
Bacterial Meningitides
Streptococcus agalactiae
Brain Edema
Random Allocation
Meningitis
Wistar Rats
Suspensions
Biomarkers
Prospective Studies
Anti-Bacterial Agents
Injections
Wounds and Injuries
Serum
Research

Keywords

  • Brain injury
  • Caspase
  • Meningitis
  • Neurobehavioral performance

ASJC Scopus subject areas

  • Critical Care and Intensive Care Medicine

Cite this

Irazuzta, J., Pretzlaff, R. K., DeCourten-Myers, G., Zemlan, F., & Zingarelli, B. (2005). Dexamethasone decreases neurological sequelae and caspase activity. Intensive Care Medicine, 31(1), 146-150. https://doi.org/10.1007/s00134-004-2462-7

Dexamethasone decreases neurological sequelae and caspase activity. / Irazuzta, Jose; Pretzlaff, Robert K.; DeCourten-Myers, Gabrielle; Zemlan, Frank; Zingarelli, Basilia.

In: Intensive Care Medicine, Vol. 31, No. 1, 01.2005, p. 146-150.

Research output: Contribution to journalArticle

Irazuzta, J, Pretzlaff, RK, DeCourten-Myers, G, Zemlan, F & Zingarelli, B 2005, 'Dexamethasone decreases neurological sequelae and caspase activity', Intensive Care Medicine, vol. 31, no. 1, pp. 146-150. https://doi.org/10.1007/s00134-004-2462-7
Irazuzta J, Pretzlaff RK, DeCourten-Myers G, Zemlan F, Zingarelli B. Dexamethasone decreases neurological sequelae and caspase activity. Intensive Care Medicine. 2005 Jan;31(1):146-150. https://doi.org/10.1007/s00134-004-2462-7
Irazuzta, Jose ; Pretzlaff, Robert K. ; DeCourten-Myers, Gabrielle ; Zemlan, Frank ; Zingarelli, Basilia. / Dexamethasone decreases neurological sequelae and caspase activity. In: Intensive Care Medicine. 2005 ; Vol. 31, No. 1. pp. 146-150.
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