Developments in the identification of glycan biomarkers for the detection of cancer

L. Renee Ruhaak, Suzanne Miyamoto, Carlito B Lebrilla

Research output: Contribution to journalArticlepeer-review

112 Scopus citations


Changes in glycosylation readily occur in cancer and other disease states. Thanks to recent advances in the development of analytical techniques and instrumentation, especially in mass spectrometry, it is now possible to identify blood-derived glycan-based biomarkers using glycomics strategies. This review is an overview of the developments made in the search for glycan-based cancer biomarkers and the technologies currently in use. It is anticipated that the progressing instrumental and bioinformatics developments will allow the identification of relevant glycan biomarkers for the diagnosis, early detection, and monitoring of cancer treatment with sufficient sensitivity and specificity for clinical use.

Original languageEnglish (US)
Pages (from-to)846-855
Number of pages10
JournalMolecular and Cellular Proteomics
Issue number4
StatePublished - Apr 2013

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Analytical Chemistry


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