Developments in the identification of glycan biomarkers for the detection of cancer

L. Renee Ruhaak, Suzanne Miyamoto, Carlito B Lebrilla

Research output: Contribution to journalArticle

93 Citations (Scopus)

Abstract

Changes in glycosylation readily occur in cancer and other disease states. Thanks to recent advances in the development of analytical techniques and instrumentation, especially in mass spectrometry, it is now possible to identify blood-derived glycan-based biomarkers using glycomics strategies. This review is an overview of the developments made in the search for glycan-based cancer biomarkers and the technologies currently in use. It is anticipated that the progressing instrumental and bioinformatics developments will allow the identification of relevant glycan biomarkers for the diagnosis, early detection, and monitoring of cancer treatment with sufficient sensitivity and specificity for clinical use.

Original languageEnglish (US)
Pages (from-to)846-855
Number of pages10
JournalMolecular and Cellular Proteomics
Volume12
Issue number4
DOIs
StatePublished - Apr 2013

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Tumor Biomarkers
Polysaccharides
Biomarkers
Glycomics
Glycosylation
Oncology
Bioinformatics
Computational Biology
Early Detection of Cancer
Mass spectrometry
Mass Spectrometry
Blood
Technology
Sensitivity and Specificity
Monitoring
Neoplasms

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Analytical Chemistry

Cite this

Developments in the identification of glycan biomarkers for the detection of cancer. / Ruhaak, L. Renee; Miyamoto, Suzanne; Lebrilla, Carlito B.

In: Molecular and Cellular Proteomics, Vol. 12, No. 4, 04.2013, p. 846-855.

Research output: Contribution to journalArticle

Ruhaak, L. Renee ; Miyamoto, Suzanne ; Lebrilla, Carlito B. / Developments in the identification of glycan biomarkers for the detection of cancer. In: Molecular and Cellular Proteomics. 2013 ; Vol. 12, No. 4. pp. 846-855.
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