Developmental toxicity of temafloxacin hydrochloride in the long-tailed macaque (Macaca fascicularis)

Alice F Tarantal, S. B. Lehrer, B. L. Lasley, Andrew G Hendrickx

Research output: Contribution to journalArticle

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Abstract

The potential developmental toxicity of temafloxacin hydrochloride was studied in the long-tailed macaque (Macaca fascicularis). Ten animals in each of the three drug-treated groups (25, 50, and 100 mg/kg) were administered temafloxacin via nasogastric intubation during gestational days (GD) 20-50. A control group of ten animals received vehicle only. The dams were monitored daily for adverse physical signs and maternal blood samples were collected for analyses of serum progesterone (P), 17β-estradiol (E2), and chorionic gonadotropin (CG). In addition, the conceptus was monitored periodically by ultrasound during gestation to confirm growth and viability. Increased maternal toxicity (weight loss, anorexia, emesis) and embryolethality were observed at 100 mg/kg, and a no-observable-adverse-effect-level (NOAEL) of 50 mg/kg was established. The incidence of prenatal mortality was as follows: Control = 1/10 (10%); 25 mg/kg = 1/10 (10%); 50 mg/kg = 2/10 (20%); and 100 mg/kg = 5/10 (50%). Analysis of P, E2, and CG indicated no significant effect of treatment. In addition, no significant differences were observed in embryonic/fetal growth and development when compared to historical controls. No gross structural changes were observed in fetuses exposed to 50 or 100 mg/kg, although one fetus exposed to 25 mg/kg exhibited microphthalmia. This anomaly was considered spontaneous and, therefore, unrelated to treatment.

Original languageEnglish (US)
Pages (from-to)233-242
Number of pages10
JournalTeratology
Volume42
Issue number3
DOIs
StatePublished - 1990

Fingerprint

temafloxacin
Macaca fascicularis
Macaca
Chorionic Gonadotropin
Toxicity
Fetus
Gastrointestinal Intubation
Embryonic and Fetal Development
Mothers
Microphthalmos
Animals
Anorexia
Fetal Development
Growth and Development
Vomiting
Progesterone
Weight Loss
Estradiol
Pregnancy
Control Groups

ASJC Scopus subject areas

  • Developmental Biology
  • Embryology
  • Toxicology
  • Health, Toxicology and Mutagenesis

Cite this

Developmental toxicity of temafloxacin hydrochloride in the long-tailed macaque (Macaca fascicularis). / Tarantal, Alice F; Lehrer, S. B.; Lasley, B. L.; Hendrickx, Andrew G.

In: Teratology, Vol. 42, No. 3, 1990, p. 233-242.

Research output: Contribution to journalArticle

Tarantal, Alice F ; Lehrer, S. B. ; Lasley, B. L. ; Hendrickx, Andrew G. / Developmental toxicity of temafloxacin hydrochloride in the long-tailed macaque (Macaca fascicularis). In: Teratology. 1990 ; Vol. 42, No. 3. pp. 233-242.
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