Developmental changes affected by Mn deficiency - Mn-Superoxide dismutase, CuZn-Superoxide dismutase, Mn, Cu, Fe, and Zn in mouse tissues

Sheri Zidenberg-Cherr, Carl L Keen, Sharon M. Casey, Lucille S. Hurley

Research output: Contribution to journalArticlepeer-review

4 Scopus citations


The changes in tissue Mn, Cu, Fe, Zn, and Superoxide dismutase (SOD) activity were studied in control and Mn-deficient mice during postnatal development. Mn levels were lower in tissues from Mn-deficient mice than in controls throughout development. By day 60, Mn concentration in tissues from Mn-deficient mice was at least 70% lower than that of controls. Cu levels in the two groups did not differ appreciably. Liver Cu concentration was highest at day 5, then decreased. Heart and kidney Cu increased throughout development. Fe concentration in heart and liver was similar in both groups at 1, 5, and 20 days of age, but at day 60, kidney Fe in the Mn-deficient mice was 40% higher than in controls. The developmental pattern for MnSOD activity paralleled that of Mn concentration. At day 5, there were no differences in MnSOD activity between control and deficient mice. By day 60, MnSOD activity in most tissues was at least 50% lower than that of controls, possibly increasing the susceptibility of the Mn deficient animal to oxidative damage. These developmental patterns should help investigators to determine the tissues and time periods in which to study trace element metabolism.

Original languageEnglish (US)
Pages (from-to)209-222
Number of pages14
JournalBiological Trace Element Research
Issue number4
StatePublished - Jun 1985


  • copper, in Mn-deficient mouse tissues
  • CuZn-SOD, and development
  • development and Mn deficiency
  • iron, in Mn-deficient mouse tissues
  • Manganese deficiency, and development
  • manganese, in developing mouse tissues
  • MnSOD, and development
  • Superoxide dismutase, in Mn-deficient mouse tissues
  • tissue Mn, and development
  • zinc, in Mn-deficient mouse tissues

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology
  • Biochemistry, Genetics and Molecular Biology(all)
  • Biochemistry, medical
  • Inorganic Chemistry
  • Clinical Biochemistry
  • Biochemistry


Dive into the research topics of 'Developmental changes affected by Mn deficiency - Mn-Superoxide dismutase, CuZn-Superoxide dismutase, Mn, Cu, Fe, and Zn in mouse tissues'. Together they form a unique fingerprint.

Cite this