Developmental appearance of the vitamin K-dependent protein of bone during calcification. Analysis of mineralizing tissues in human, calf, and rat

P. A. Price, J. W. Lothringer, S. A. Baukol, A Hari Reddi

Research output: Contribution to journalArticle

110 Scopus citations

Abstract

Several mineralizing tissues have been analyzed for the vitamin K-dependent protein of bone (BGP) in order to establish the temporal relationship between initial mineral deposition and the appearance of BGP. These studies demonstrate that the appearance of BGP in developing bone is not dependent on birth, as had been suggested in earlier studies of rat development, but rather on the prior deposition of bone mineral. In fetal human bone, the level of BGP (grams of BGP/mol of bone PO4) rises from 5% of the adult level at 10 weeks gestational age to the adult level at 15 weeks. Thus, adult levels of BGP are reached in human bone shortly after the initial appearance of mineral and long before birth. In adolescent rats, which have overall levels of BGP in bone near the adult level, the appearance of BGP at the ends of growing bones and in bone induced by implantation of demineralized bone matrix follows mineral deposition by approximately 2 weeks. The relative absence of BGP in intially deposited bone mineral and its subsequent appearance several days later may be causally related to the maturation of bone mineral to hydroxyapatite, a structure which binds BGP. The implications of the timing of BGP appearance in mineralizing tissues to its possible function in bone are discussed.

Original languageEnglish (US)
Pages (from-to)3781-3784
Number of pages4
JournalJournal of Biological Chemistry
Volume256
Issue number8
StatePublished - 1981

ASJC Scopus subject areas

  • Biochemistry

Fingerprint Dive into the research topics of 'Developmental appearance of the vitamin K-dependent protein of bone during calcification. Analysis of mineralizing tissues in human, calf, and rat'. Together they form a unique fingerprint.

  • Cite this