Developmental and regional differences in the localization of Na,K-ATPase activity in the rabbit hippocampus

Michael M. Haglund, William L. Stahl, Dennis D. Kunkel, Philip A Schwartzkroin

Research output: Contribution to journalArticle

41 Scopus citations

Abstract

Regional differences in Na,K-ATPase activity, and development of Na,K-ATPase activity were examined in rabbit hippocampus using a histochemical marker of enzyme activity. Stratum lucidum of CA3/CA2, corresponding to the mossy fiber terminal field, showed high Na,K-ATPase activity compared to stratum radiatum of CA1. A significant increase in Na,K-ATPase activity was found between 8 and 15 days postnatal. Tissues with limited Na,K-ATPase activity (immature hippocampus, the mature CA1 region) appear particularly prone to seizure-like abnormalities, perhaps reflecting an inability to regulate extracellular potassium.

Original languageEnglish (US)
Pages (from-to)198-203
Number of pages6
JournalBrain Research
Volume343
Issue number1
DOIs
StatePublished - Sep 16 1985
Externally publishedYes

Keywords

  • hippocampus
  • Na,K-ATPase
  • seizure

ASJC Scopus subject areas

  • Developmental Biology
  • Molecular Biology
  • Clinical Neurology
  • Neuroscience(all)

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