Developmental and regional differences in the localization of Na,K-ATPase activity in the rabbit hippocampus

Michael M. Haglund, William L. Stahl, Dennis D. Kunkel, Philip A Schwartzkroin

Research output: Contribution to journalArticle

41 Citations (Scopus)

Abstract

Regional differences in Na,K-ATPase activity, and development of Na,K-ATPase activity were examined in rabbit hippocampus using a histochemical marker of enzyme activity. Stratum lucidum of CA3/CA2, corresponding to the mossy fiber terminal field, showed high Na,K-ATPase activity compared to stratum radiatum of CA1. A significant increase in Na,K-ATPase activity was found between 8 and 15 days postnatal. Tissues with limited Na,K-ATPase activity (immature hippocampus, the mature CA1 region) appear particularly prone to seizure-like abnormalities, perhaps reflecting an inability to regulate extracellular potassium.

Original languageEnglish (US)
Pages (from-to)198-203
Number of pages6
JournalBrain Research
Volume343
Issue number1
DOIs
StatePublished - Sep 16 1985
Externally publishedYes

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Hippocampus
Rabbits
Hippocampal CA3 Region
Hippocampal CA1 Region
Potassium
Seizures
sodium-translocating ATPase
Enzymes

Keywords

  • hippocampus
  • Na,K-ATPase
  • seizure

ASJC Scopus subject areas

  • Developmental Biology
  • Molecular Biology
  • Clinical Neurology
  • Neuroscience(all)

Cite this

Developmental and regional differences in the localization of Na,K-ATPase activity in the rabbit hippocampus. / Haglund, Michael M.; Stahl, William L.; Kunkel, Dennis D.; Schwartzkroin, Philip A.

In: Brain Research, Vol. 343, No. 1, 16.09.1985, p. 198-203.

Research output: Contribution to journalArticle

Haglund, Michael M. ; Stahl, William L. ; Kunkel, Dennis D. ; Schwartzkroin, Philip A. / Developmental and regional differences in the localization of Na,K-ATPase activity in the rabbit hippocampus. In: Brain Research. 1985 ; Vol. 343, No. 1. pp. 198-203.
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