Developmental and Physiologicalaging of the Lung

Kent E Pinkerton, Lei Wang, Suzette M. Smiley-Jewell, Jingyi Xu, Francis H Y Green

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations


Lung development and aging is a continuum that begins in utero and continues throughout life. This chapter provides a brief overview of the aging lung along with information on how the lung changes with age in the rat, which due to its size and lifespan is ideal for studies of the maturing lung. The dynamics of lung growth, development, and aging are a continuous process, which involves every tissue compartment of the lungs. As such changes may influence the response of the lungs to inhaled chemical agents and dusts, the age of any animal model should be considered in the evaluation of any experimental study. Changes in cell number, size, and function associated with aging are likely to impact on lung physiology, metabolism, and immunity. Such changes could significantly alter the normal functions of the lung and its susceptibility to injury.

Original languageEnglish (US)
Title of host publicationMolecular Aspects of Aging: Understanding Lung Aging
PublisherWiley Blackwell
Number of pages17
ISBN (Print)9781118396292, 9781118396247
StatePublished - Jun 3 2014


  • Aging lung
  • Antioxidant defenses
  • Hormonal changes
  • Immune system changes
  • Lung function
  • Oxidative stress defenses

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)


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