Developmental aluminum toxicity in mice can be modulated by low concentrations of minerals (Fe, Zn, P, Ca, Mg) in the diet

Mari S. Golub, Stacey L. Germann, Carl L Keen

Research output: Contribution to journalArticle

9 Scopus citations

Abstract

Female Swiss Webster mice were fed diets containing 7 (control) or 1000 μg Al/g diet from conception to weaning. Pregnancy weight gain, birth weight, litter size, postnatal mortality, and weaning weight were measured. In different groups, diets low in Fe, Zn, P, or Ca and Mg (CaMg) were used as basal diets, to which Al was added. Relative to controls, who received NRC recommended levels of these nutrients, all diets with marginal essential trace elements impacted development, as demonstrated by effects on birth weight (CaMg, Fe) or weaning weight (Fe, Zn, P). Compared to diets low in Al, the 1000-mg Al/g diet led to reduced weaning weight regardless of the essential element content of the diet. Other end points were influenced by Al only within the basal-diet group; pregnancy weight gain with the low-P diet, litter size with the low-Fe diet, pregnancy completion with the low-Zn diet, and postnatal mortality with the low-CaMg or low-Zn diet. Thus, diets marginal in selected minerals can differentially alter the toxicological profile of developmental Al exposures. A basal diet was also used in which the NRC diet was supplemented with ascorbic acid, which promotes Al absorption. No modification of Al toxicity was seen with ascorbic acid supplementation.

Original languageEnglish (US)
Pages (from-to)213-225
Number of pages13
JournalBiological Trace Element Research
Volume93
Issue number1-3
DOIs
StatePublished - Jun 2003

Keywords

  • Aluminum
  • Ascorbic acid
  • Calcium
  • Development
  • Iron
  • Magnesium
  • Mice
  • Phosphorous
  • Toxicity
  • Zinc

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Endocrinology
  • Endocrinology, Diabetes and Metabolism

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