Developmental aluminum toxicity in mice can be modulated by low concentrations of minerals (Fe, Zn, P, Ca, Mg) in the diet

Mari S. Golub, Stacey L. Germann, Carl L Keen

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Female Swiss Webster mice were fed diets containing 7 (control) or 1000 μg Al/g diet from conception to weaning. Pregnancy weight gain, birth weight, litter size, postnatal mortality, and weaning weight were measured. In different groups, diets low in Fe, Zn, P, or Ca and Mg (CaMg) were used as basal diets, to which Al was added. Relative to controls, who received NRC recommended levels of these nutrients, all diets with marginal essential trace elements impacted development, as demonstrated by effects on birth weight (CaMg, Fe) or weaning weight (Fe, Zn, P). Compared to diets low in Al, the 1000-mg Al/g diet led to reduced weaning weight regardless of the essential element content of the diet. Other end points were influenced by Al only within the basal-diet group; pregnancy weight gain with the low-P diet, litter size with the low-Fe diet, pregnancy completion with the low-Zn diet, and postnatal mortality with the low-CaMg or low-Zn diet. Thus, diets marginal in selected minerals can differentially alter the toxicological profile of developmental Al exposures. A basal diet was also used in which the NRC diet was supplemented with ascorbic acid, which promotes Al absorption. No modification of Al toxicity was seen with ascorbic acid supplementation.

Original languageEnglish (US)
Pages (from-to)213-225
Number of pages13
JournalBiological Trace Element Research
Volume93
Issue number1-3
DOIs
StatePublished - Jun 2003

Fingerprint

Nutrition
Aluminum
Minerals
Toxicity
Diet
Weaning
Litter Size
Weights and Measures
Birth Weight
Pregnancy
Ascorbic Acid
Weight Gain
Mortality
Trace Elements
Toxicology
Nutrients

Keywords

  • Aluminum
  • Ascorbic acid
  • Calcium
  • Development
  • Iron
  • Magnesium
  • Mice
  • Phosphorous
  • Toxicity
  • Zinc

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Endocrinology
  • Endocrinology, Diabetes and Metabolism

Cite this

Developmental aluminum toxicity in mice can be modulated by low concentrations of minerals (Fe, Zn, P, Ca, Mg) in the diet. / Golub, Mari S.; Germann, Stacey L.; Keen, Carl L.

In: Biological Trace Element Research, Vol. 93, No. 1-3, 06.2003, p. 213-225.

Research output: Contribution to journalArticle

@article{fec239980fe44410b1d37865fa2ab598,
title = "Developmental aluminum toxicity in mice can be modulated by low concentrations of minerals (Fe, Zn, P, Ca, Mg) in the diet",
abstract = "Female Swiss Webster mice were fed diets containing 7 (control) or 1000 μg Al/g diet from conception to weaning. Pregnancy weight gain, birth weight, litter size, postnatal mortality, and weaning weight were measured. In different groups, diets low in Fe, Zn, P, or Ca and Mg (CaMg) were used as basal diets, to which Al was added. Relative to controls, who received NRC recommended levels of these nutrients, all diets with marginal essential trace elements impacted development, as demonstrated by effects on birth weight (CaMg, Fe) or weaning weight (Fe, Zn, P). Compared to diets low in Al, the 1000-mg Al/g diet led to reduced weaning weight regardless of the essential element content of the diet. Other end points were influenced by Al only within the basal-diet group; pregnancy weight gain with the low-P diet, litter size with the low-Fe diet, pregnancy completion with the low-Zn diet, and postnatal mortality with the low-CaMg or low-Zn diet. Thus, diets marginal in selected minerals can differentially alter the toxicological profile of developmental Al exposures. A basal diet was also used in which the NRC diet was supplemented with ascorbic acid, which promotes Al absorption. No modification of Al toxicity was seen with ascorbic acid supplementation.",
keywords = "Aluminum, Ascorbic acid, Calcium, Development, Iron, Magnesium, Mice, Phosphorous, Toxicity, Zinc",
author = "Golub, {Mari S.} and Germann, {Stacey L.} and Keen, {Carl L}",
year = "2003",
month = "6",
doi = "10.1385/BTER:93:1-3:213",
language = "English (US)",
volume = "93",
pages = "213--225",
journal = "Biological Trace Element Research",
issn = "0163-4984",
publisher = "Humana Press",
number = "1-3",

}

TY - JOUR

T1 - Developmental aluminum toxicity in mice can be modulated by low concentrations of minerals (Fe, Zn, P, Ca, Mg) in the diet

AU - Golub, Mari S.

AU - Germann, Stacey L.

AU - Keen, Carl L

PY - 2003/6

Y1 - 2003/6

N2 - Female Swiss Webster mice were fed diets containing 7 (control) or 1000 μg Al/g diet from conception to weaning. Pregnancy weight gain, birth weight, litter size, postnatal mortality, and weaning weight were measured. In different groups, diets low in Fe, Zn, P, or Ca and Mg (CaMg) were used as basal diets, to which Al was added. Relative to controls, who received NRC recommended levels of these nutrients, all diets with marginal essential trace elements impacted development, as demonstrated by effects on birth weight (CaMg, Fe) or weaning weight (Fe, Zn, P). Compared to diets low in Al, the 1000-mg Al/g diet led to reduced weaning weight regardless of the essential element content of the diet. Other end points were influenced by Al only within the basal-diet group; pregnancy weight gain with the low-P diet, litter size with the low-Fe diet, pregnancy completion with the low-Zn diet, and postnatal mortality with the low-CaMg or low-Zn diet. Thus, diets marginal in selected minerals can differentially alter the toxicological profile of developmental Al exposures. A basal diet was also used in which the NRC diet was supplemented with ascorbic acid, which promotes Al absorption. No modification of Al toxicity was seen with ascorbic acid supplementation.

AB - Female Swiss Webster mice were fed diets containing 7 (control) or 1000 μg Al/g diet from conception to weaning. Pregnancy weight gain, birth weight, litter size, postnatal mortality, and weaning weight were measured. In different groups, diets low in Fe, Zn, P, or Ca and Mg (CaMg) were used as basal diets, to which Al was added. Relative to controls, who received NRC recommended levels of these nutrients, all diets with marginal essential trace elements impacted development, as demonstrated by effects on birth weight (CaMg, Fe) or weaning weight (Fe, Zn, P). Compared to diets low in Al, the 1000-mg Al/g diet led to reduced weaning weight regardless of the essential element content of the diet. Other end points were influenced by Al only within the basal-diet group; pregnancy weight gain with the low-P diet, litter size with the low-Fe diet, pregnancy completion with the low-Zn diet, and postnatal mortality with the low-CaMg or low-Zn diet. Thus, diets marginal in selected minerals can differentially alter the toxicological profile of developmental Al exposures. A basal diet was also used in which the NRC diet was supplemented with ascorbic acid, which promotes Al absorption. No modification of Al toxicity was seen with ascorbic acid supplementation.

KW - Aluminum

KW - Ascorbic acid

KW - Calcium

KW - Development

KW - Iron

KW - Magnesium

KW - Mice

KW - Phosphorous

KW - Toxicity

KW - Zinc

UR - http://www.scopus.com/inward/record.url?scp=0042668290&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0042668290&partnerID=8YFLogxK

U2 - 10.1385/BTER:93:1-3:213

DO - 10.1385/BTER:93:1-3:213

M3 - Article

C2 - 12835503

AN - SCOPUS:0042668290

VL - 93

SP - 213

EP - 225

JO - Biological Trace Element Research

JF - Biological Trace Element Research

SN - 0163-4984

IS - 1-3

ER -