Development of tumor targeting magnetic nanoparticles for cancer therapy

Robert Ivkov, Sally J. DeNardo, Laird A. Miers, Arutselvan Natarajan, Allan R. Foreman, Cordula Gruettner, Grete N. Adamson, Gerald L Denardo

Research output: Chapter in Book/Report/Conference proceedingConference contribution

6 Scopus citations

Abstract

Magnetic nanoparticles will heat when activated by an alternating magnetic field (AMF). Systemic delivery of magnetic nanoparticles conjugated to a monoclonal antibody (MAb) offers potential for selective and minimally invasive cancer treatment by heating the microenvironments of cells containing such particles. 111In-Chimeric L6 (Ch L6) antibody was conjugated to carboxylated polyethylene glycol (PEG-COOH) on dextran-coated iron oxide 20-nm particles to yield bioprobes. Pharmaco-kinetics, histopathology, and AMF/bioprobe therapy were done using intravenous doses (20μg/2.2mg ChL6/ bioprobe) with 50μg ChL6 in athymic mice bearing human breast tumor, HBT3477, xenografts. A 153 kHz AMF was applied 72 hr post injection for therapy using several AMF amplitudes. Significant therapeutic response was demonstrated. Toxicity was observed only at extreme AMF conditions, and was due to nonspecific heating resulting from the AMF.

Original languageEnglish (US)
Title of host publication2006 NSTI Nanotechnology Conference and Trade Show - NSTI Nanotech 2006 Technical Proceedings
Pages21-24
Number of pages4
Volume2
StatePublished - 2006
Event2006 NSTI Nanotechnology Conference and Trade Show - NSTI Nanotech 2006 Technical Proceedings - Boston, MA, United States
Duration: May 7 2006May 11 2006

Other

Other2006 NSTI Nanotechnology Conference and Trade Show - NSTI Nanotech 2006 Technical Proceedings
CountryUnited States
CityBoston, MA
Period5/7/065/11/06

Keywords

  • Cancer
  • Magnetic nanoparticles
  • Monoclonal antibodies (MAb)
  • Thermoablation

ASJC Scopus subject areas

  • Engineering(all)

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  • Cite this

    Ivkov, R., DeNardo, S. J., Miers, L. A., Natarajan, A., Foreman, A. R., Gruettner, C., Adamson, G. N., & Denardo, G. L. (2006). Development of tumor targeting magnetic nanoparticles for cancer therapy. In 2006 NSTI Nanotechnology Conference and Trade Show - NSTI Nanotech 2006 Technical Proceedings (Vol. 2, pp. 21-24)