Development of somatostatin-containing neurons and fibers in the rat hippocampus

C. C G Naus, John Morrison, F. E. Bloom

Research output: Contribution to journalArticle

47 Citations (Scopus)

Abstract

Using a combination of in situ hybridization and immunohistochemistry, the development of somatostatin (SS)-containing neurons and fibers was examined in the rat dorsal hippocampus and dentate gyrus. The major development of this hippocampal peptidergic system occurs postnatally. At postnatal day 1 (P1), neurons containing SS mRNA are evident primarily in the stratum oriens, but also in the hilus of the dentate gyrus. Similar neurons are also immunoreactive for SS28 and SS28(1-12), suggesting a minimal lag in the transcription of SS mRNA and its translation into specific SS peptides. The number of SS neurons increases postnatally to P10, followed by a decrease in number in the adult. This transient change in the number of SS neurons coincides with dramatic changes in SS28(1-12)-immunoreactive fibers, which are initially present in the stratum lacunosum moleculare, with no significant immunoreactivity in the dentate gyrus. By P15, the molecular layer of the dentate gyrus is densely innervated, while similar immunoreactivity in the stratum lacunosum moleculare is greatly reduced. These data are consistent with a transient projection from the stratum oriens to the stratum lacunosum moleculare, which is replaced by a projection from the hilus to the molecular layer of the dentate gyrus as this structure matures.

Original languageEnglish (US)
Pages (from-to)113-121
Number of pages9
JournalDevelopmental Brain Research
Volume40
Issue number1
DOIs
StatePublished - May 1 1988
Externally publishedYes

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Somatostatin
Dentate Gyrus
Hippocampus
Neurons
Protein Biosynthesis
In Situ Hybridization
Immunohistochemistry
Messenger RNA
Peptides

Keywords

  • Development
  • Hippocampus
  • Immunohistochemistry
  • In situ hybridization
  • Somatostatin

ASJC Scopus subject areas

  • Developmental Biology
  • Developmental Neuroscience

Cite this

Development of somatostatin-containing neurons and fibers in the rat hippocampus. / Naus, C. C G; Morrison, John; Bloom, F. E.

In: Developmental Brain Research, Vol. 40, No. 1, 01.05.1988, p. 113-121.

Research output: Contribution to journalArticle

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