Development of rabbit hippocampus: anatomy.

Philip A Schwartzkroin, D. D. Kunkel, L. H. Mathers

Research output: Contribution to journalArticle

71 Citations (Scopus)

Abstract

The postnatal development of the CA1 region of rabbit hippocampus was studied using a variety of light and electron microscopic (EM) techniques. Nissl and Golgi stains showed high cellular density, small cell soma area, and sparse dendritic branching in neurons of immature animals (less than 1 week old); dendritic spines were also relatively infrequent during this period. Cell branching and spine frequency reached near-adult levels by 3 weeks, with the major area of hippocampal expansion seen in the apical dendritic layer. EM examination of synapse patterns was made using osmicated and E-PTA-treated tissue. Both techniques showed that the vast majority of synapses in immature animals (less than 2 weeks old) occurred in the dendritic region and were of the asymmetric type. Axosomatic synapses became less rare by 2 weeks; they were usually of the symmetric synapse type. The pattern of synaptic contacts in immature hippocampus resembled the mature pattern by 3-4 weeks. These data suggest a relatively late development of inhibitory postsynaptic potentials in CA1 pyramidal cells.

Original languageEnglish (US)
Pages (from-to)453-468
Number of pages16
JournalBrain Research
Volume254
Issue number4
StatePublished - Nov 1981
Externally publishedYes

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Synapses
Hippocampus
Anatomy
Rabbits
Electrons
Inhibitory Postsynaptic Potentials
Dendritic Spines
Pyramidal Cells
Carisoprodol
Spine
Coloring Agents
Cell Count
Neurons
Light

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Schwartzkroin, P. A., Kunkel, D. D., & Mathers, L. H. (1981). Development of rabbit hippocampus: anatomy. Brain Research, 254(4), 453-468.

Development of rabbit hippocampus : anatomy. / Schwartzkroin, Philip A; Kunkel, D. D.; Mathers, L. H.

In: Brain Research, Vol. 254, No. 4, 11.1981, p. 453-468.

Research output: Contribution to journalArticle

Schwartzkroin, PA, Kunkel, DD & Mathers, LH 1981, 'Development of rabbit hippocampus: anatomy.', Brain Research, vol. 254, no. 4, pp. 453-468.
Schwartzkroin PA, Kunkel DD, Mathers LH. Development of rabbit hippocampus: anatomy. Brain Research. 1981 Nov;254(4):453-468.
Schwartzkroin, Philip A ; Kunkel, D. D. ; Mathers, L. H. / Development of rabbit hippocampus : anatomy. In: Brain Research. 1981 ; Vol. 254, No. 4. pp. 453-468.
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