Development of quantitative diagnostic observables for age-related macular degeneration using Spectral Domain OCT

Bradley A. Bower, Stephanie J. Chiu, Emily Davies, Anjul M. Davis, Robert Zawadzki, Alfred R. Fuller, David F. Wiley, Joseph A. Izatt, Cynthia A. Toth

Research output: Chapter in Book/Report/Conference proceedingConference contribution

3 Citations (Scopus)

Abstract

We report on the development of quantitative, reproducible diagnostic observables for age-related macular degeneration (AMD) based on high speed spectral domain optical coherence tomography (SDOCT). 3D SDOCT volumetric data sets (512 × 1000 × 100 voxels) were collected (5.7 seconds acquisition time) in over 50 patients with age-related macular degeneration and geographic atrophy using a state-of-the-art SDOCT scanner. Commercial and custom software utilities were used for manual and semi-automated segmentation of photoreceptor layer thickness, total drusen volume, and geographic atrophy cross-sectional area. In a preliminary test of reproducibility in segmentation of total drusen volume and geographic atrophy surface area, inter-observer error was less than 5%. Extracted volume and surface area of AMDrelated drusen and geographic atrophy, respectively, may serve as useful observables for tracking disease state that were not accessible without the rapid 3D volumetric imaging capability unique to retinal SDOCT.

Original languageEnglish (US)
Title of host publicationOphthalmic Technologies XVII
Volume6426
DOIs
StatePublished - Aug 31 2007
EventOphthalmic Technologies XVII - San Jose, CA, United States
Duration: Jan 20 2007Jan 23 2007

Other

OtherOphthalmic Technologies XVII
CountryUnited States
CitySan Jose, CA
Period1/20/071/23/07

Fingerprint

Geographic Atrophy
atrophy
degeneration
Optical tomography
Optical Coherence Tomography
Macular Degeneration
tomography
photoreceptors
scanners
acquisition
Software
high speed
computer programs
Imaging techniques

Keywords

  • Age-related macular degeneration
  • Optical coherence tomography

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Atomic and Molecular Physics, and Optics
  • Biomaterials
  • Radiology Nuclear Medicine and imaging

Cite this

Bower, B. A., Chiu, S. J., Davies, E., Davis, A. M., Zawadzki, R., Fuller, A. R., ... Toth, C. A. (2007). Development of quantitative diagnostic observables for age-related macular degeneration using Spectral Domain OCT. In Ophthalmic Technologies XVII (Vol. 6426). [64260W] https://doi.org/10.1117/12.704689

Development of quantitative diagnostic observables for age-related macular degeneration using Spectral Domain OCT. / Bower, Bradley A.; Chiu, Stephanie J.; Davies, Emily; Davis, Anjul M.; Zawadzki, Robert; Fuller, Alfred R.; Wiley, David F.; Izatt, Joseph A.; Toth, Cynthia A.

Ophthalmic Technologies XVII. Vol. 6426 2007. 64260W.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Bower, BA, Chiu, SJ, Davies, E, Davis, AM, Zawadzki, R, Fuller, AR, Wiley, DF, Izatt, JA & Toth, CA 2007, Development of quantitative diagnostic observables for age-related macular degeneration using Spectral Domain OCT. in Ophthalmic Technologies XVII. vol. 6426, 64260W, Ophthalmic Technologies XVII, San Jose, CA, United States, 1/20/07. https://doi.org/10.1117/12.704689
Bower BA, Chiu SJ, Davies E, Davis AM, Zawadzki R, Fuller AR et al. Development of quantitative diagnostic observables for age-related macular degeneration using Spectral Domain OCT. In Ophthalmic Technologies XVII. Vol. 6426. 2007. 64260W https://doi.org/10.1117/12.704689
Bower, Bradley A. ; Chiu, Stephanie J. ; Davies, Emily ; Davis, Anjul M. ; Zawadzki, Robert ; Fuller, Alfred R. ; Wiley, David F. ; Izatt, Joseph A. ; Toth, Cynthia A. / Development of quantitative diagnostic observables for age-related macular degeneration using Spectral Domain OCT. Ophthalmic Technologies XVII. Vol. 6426 2007.
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