Abstract
We report on the development of quantitative, reproducible diagnostic observables for age-related macular degeneration (AMD) based on high speed spectral domain optical coherence tomography (SDOCT). 3D SDOCT volumetric data sets (512 × 1000 × 100 voxels) were collected (5.7 seconds acquisition time) in over 50 patients with age-related macular degeneration and geographic atrophy using a state-of-the-art SDOCT scanner. Commercial and custom software utilities were used for manual and semi-automated segmentation of photoreceptor layer thickness, total drusen volume, and geographic atrophy cross-sectional area. In a preliminary test of reproducibility in segmentation of total drusen volume and geographic atrophy surface area, inter-observer error was less than 5%. Extracted volume and surface area of AMDrelated drusen and geographic atrophy, respectively, may serve as useful observables for tracking disease state that were not accessible without the rapid 3D volumetric imaging capability unique to retinal SDOCT.
| Original language | English (US) |
|---|---|
| Title of host publication | Ophthalmic Technologies XVII |
| Volume | 6426 |
| DOIs | |
| State | Published - Aug 31 2007 |
| Event | Ophthalmic Technologies XVII - San Jose, CA, United States Duration: Jan 20 2007 → Jan 23 2007 |
Other
| Other | Ophthalmic Technologies XVII |
|---|---|
| Country | United States |
| City | San Jose, CA |
| Period | 1/20/07 → 1/23/07 |
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Keywords
- Age-related macular degeneration
- Optical coherence tomography
ASJC Scopus subject areas
- Electronic, Optical and Magnetic Materials
- Atomic and Molecular Physics, and Optics
- Biomaterials
- Radiology Nuclear Medicine and imaging
Cite this
Development of quantitative diagnostic observables for age-related macular degeneration using Spectral Domain OCT. / Bower, Bradley A.; Chiu, Stephanie J.; Davies, Emily; Davis, Anjul M.; Zawadzki, Robert; Fuller, Alfred R.; Wiley, David F.; Izatt, Joseph A.; Toth, Cynthia A.
Ophthalmic Technologies XVII. Vol. 6426 2007. 64260W.Research output: Chapter in Book/Report/Conference proceeding › Conference contribution
}
TY - GEN
T1 - Development of quantitative diagnostic observables for age-related macular degeneration using Spectral Domain OCT
AU - Bower, Bradley A.
AU - Chiu, Stephanie J.
AU - Davies, Emily
AU - Davis, Anjul M.
AU - Zawadzki, Robert
AU - Fuller, Alfred R.
AU - Wiley, David F.
AU - Izatt, Joseph A.
AU - Toth, Cynthia A.
PY - 2007/8/31
Y1 - 2007/8/31
N2 - We report on the development of quantitative, reproducible diagnostic observables for age-related macular degeneration (AMD) based on high speed spectral domain optical coherence tomography (SDOCT). 3D SDOCT volumetric data sets (512 × 1000 × 100 voxels) were collected (5.7 seconds acquisition time) in over 50 patients with age-related macular degeneration and geographic atrophy using a state-of-the-art SDOCT scanner. Commercial and custom software utilities were used for manual and semi-automated segmentation of photoreceptor layer thickness, total drusen volume, and geographic atrophy cross-sectional area. In a preliminary test of reproducibility in segmentation of total drusen volume and geographic atrophy surface area, inter-observer error was less than 5%. Extracted volume and surface area of AMDrelated drusen and geographic atrophy, respectively, may serve as useful observables for tracking disease state that were not accessible without the rapid 3D volumetric imaging capability unique to retinal SDOCT.
AB - We report on the development of quantitative, reproducible diagnostic observables for age-related macular degeneration (AMD) based on high speed spectral domain optical coherence tomography (SDOCT). 3D SDOCT volumetric data sets (512 × 1000 × 100 voxels) were collected (5.7 seconds acquisition time) in over 50 patients with age-related macular degeneration and geographic atrophy using a state-of-the-art SDOCT scanner. Commercial and custom software utilities were used for manual and semi-automated segmentation of photoreceptor layer thickness, total drusen volume, and geographic atrophy cross-sectional area. In a preliminary test of reproducibility in segmentation of total drusen volume and geographic atrophy surface area, inter-observer error was less than 5%. Extracted volume and surface area of AMDrelated drusen and geographic atrophy, respectively, may serve as useful observables for tracking disease state that were not accessible without the rapid 3D volumetric imaging capability unique to retinal SDOCT.
KW - Age-related macular degeneration
KW - Optical coherence tomography
UR - http://www.scopus.com/inward/record.url?scp=34548257321&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=34548257321&partnerID=8YFLogxK
U2 - 10.1117/12.704689
DO - 10.1117/12.704689
M3 - Conference contribution
AN - SCOPUS:34548257321
SN - 0819465399
SN - 9780819465399
VL - 6426
BT - Ophthalmic Technologies XVII
ER -