Development of quantitative diagnostic observables for age-related macular degeneration using Spectral Domain OCT

Bradley A. Bower; Stephanie J. Chiu; Emily Davies; Anjul M. Davis; Robert Zawadzki; Alfred R. Fuller; David F. Wiley; Joseph A. Izatt; Cynthia A. Toth

doi:10.1117/12.704689

Development of quantitative diagnostic observables for age-related macular degeneration using Spectral Domain OCT

Bradley A. Bower, Stephanie J. Chiu, Emily Davies, Anjul M. Davis, Robert Zawadzki, Alfred R. Fuller, David F. Wiley, Joseph A. Izatt, Cynthia A. Toth

Ophthalmology and Vision Science

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

3 Scopus citations

Abstract

We report on the development of quantitative, reproducible diagnostic observables for age-related macular degeneration (AMD) based on high speed spectral domain optical coherence tomography (SDOCT). 3D SDOCT volumetric data sets (512 × 1000 × 100 voxels) were collected (5.7 seconds acquisition time) in over 50 patients with age-related macular degeneration and geographic atrophy using a state-of-the-art SDOCT scanner. Commercial and custom software utilities were used for manual and semi-automated segmentation of photoreceptor layer thickness, total drusen volume, and geographic atrophy cross-sectional area. In a preliminary test of reproducibility in segmentation of total drusen volume and geographic atrophy surface area, inter-observer error was less than 5%. Extracted volume and surface area of AMDrelated drusen and geographic atrophy, respectively, may serve as useful observables for tracking disease state that were not accessible without the rapid 3D volumetric imaging capability unique to retinal SDOCT.

Original language	English (US)
Title of host publication	Ophthalmic Technologies XVII
Volume	6426
DOIs	https://doi.org/10.1117/12.704689
State	Published - Aug 31 2007
Event	Ophthalmic Technologies XVII - San Jose, CA, United States Duration: Jan 20 2007 → Jan 23 2007

Other

Other	Ophthalmic Technologies XVII
Country	United States
City	San Jose, CA
Period	1/20/07 → 1/23/07

Keywords

Age-related macular degeneration
Optical coherence tomography

ASJC Scopus subject areas

Electronic, Optical and Magnetic Materials
Atomic and Molecular Physics, and Optics
Biomaterials
Radiology Nuclear Medicine and imaging

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10.1117/12.704689

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Development of quantitative diagnostic observables for age-related macular degeneration using Spectral Domain OCT. / Bower, Bradley A.; Chiu, Stephanie J.; Davies, Emily; Davis, Anjul M.; Zawadzki, Robert; Fuller, Alfred R.; Wiley, David F.; Izatt, Joseph A.; Toth, Cynthia A.

Ophthalmic Technologies XVII. Vol. 6426 2007. 64260W.

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Bower, BA, Chiu, SJ, Davies, E, Davis, AM, Zawadzki, R, Fuller, AR, Wiley, DF, Izatt, JA & Toth, CA 2007, Development of quantitative diagnostic observables for age-related macular degeneration using Spectral Domain OCT. in Ophthalmic Technologies XVII. vol. 6426, 64260W, Ophthalmic Technologies XVII, San Jose, CA, United States, 1/20/07. https://doi.org/10.1117/12.704689

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abstract = "We report on the development of quantitative, reproducible diagnostic observables for age-related macular degeneration (AMD) based on high speed spectral domain optical coherence tomography (SDOCT). 3D SDOCT volumetric data sets (512 × 1000 × 100 voxels) were collected (5.7 seconds acquisition time) in over 50 patients with age-related macular degeneration and geographic atrophy using a state-of-the-art SDOCT scanner. Commercial and custom software utilities were used for manual and semi-automated segmentation of photoreceptor layer thickness, total drusen volume, and geographic atrophy cross-sectional area. In a preliminary test of reproducibility in segmentation of total drusen volume and geographic atrophy surface area, inter-observer error was less than 5%. Extracted volume and surface area of AMDrelated drusen and geographic atrophy, respectively, may serve as useful observables for tracking disease state that were not accessible without the rapid 3D volumetric imaging capability unique to retinal SDOCT.",

keywords = "Age-related macular degeneration, Optical coherence tomography",

author = "Bower, {Bradley A.} and Chiu, {Stephanie J.} and Emily Davies and Davis, {Anjul M.} and Robert Zawadzki and Fuller, {Alfred R.} and Wiley, {David F.} and Izatt, {Joseph A.} and Toth, {Cynthia A.}",

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AU - Zawadzki, Robert

AU - Fuller, Alfred R.

AU - Wiley, David F.

AU - Izatt, Joseph A.

AU - Toth, Cynthia A.

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AB - We report on the development of quantitative, reproducible diagnostic observables for age-related macular degeneration (AMD) based on high speed spectral domain optical coherence tomography (SDOCT). 3D SDOCT volumetric data sets (512 × 1000 × 100 voxels) were collected (5.7 seconds acquisition time) in over 50 patients with age-related macular degeneration and geographic atrophy using a state-of-the-art SDOCT scanner. Commercial and custom software utilities were used for manual and semi-automated segmentation of photoreceptor layer thickness, total drusen volume, and geographic atrophy cross-sectional area. In a preliminary test of reproducibility in segmentation of total drusen volume and geographic atrophy surface area, inter-observer error was less than 5%. Extracted volume and surface area of AMDrelated drusen and geographic atrophy, respectively, may serve as useful observables for tracking disease state that were not accessible without the rapid 3D volumetric imaging capability unique to retinal SDOCT.

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