Development of protective immunity to Salmonella, a mucosal pathogen with a systemic agenda

A. J. Griffin, Stephen J Mcsorley

Research output: Contribution to journalArticlepeer-review

85 Scopus citations

Abstract

Salmonella infections can cause a range of intestinal and systemic diseases in human and animal hosts. Although some Salmonella serovars initiate a localized intestinal inflammatory response, others use the intestine as a portal of entry to initiate a systemic infection. Considerable progress has been made in understanding bacterial invasion and dissemination strategies, as well as the nature of the Salmonella-specific immune response to oral infection. Innate and adaptive immunity are rapidly initiated after oral infection, but these effector responses can also be hindered by bacterial evasion strategies. Furthermore, although Salmonella resides within intramacrophage phagosomes, recent studies have highlighted a surprising collaboration of CD4+ Th1, Th17, and B-cell responses in mediating resistance to Salmonella infection.

Original languageEnglish (US)
Pages (from-to)371-382
Number of pages12
JournalMucosal Immunology
Volume4
Issue number4
DOIs
StatePublished - Jul 2011
Externally publishedYes

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy

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