Abstract
Pigs are ideal animal models for airway surgical research, facilitating the successful translation of science into clinical practice. Despite their ubiquitous use, there is a paucity of information on the perioperative care of pigs, especially for major procedures. In a series of experiments to investigate laryngeal transplantation, we combined veterinary and medical experience to develop protocols for perioperative management of pigs, including high dependency care. Novel airway management methods were developed. A pain scoring system was used to direct analgesia use. Fluid balance and electrolytes were monitored closely. Recent animals received a central venous line via the femoral vein two days prior to transplantation to facilitate blood sampling and drug delivery. Intensive monitoring and airway management were required to ensure a successful outcome. Methods for optimal perioperative care are proposed. These results will help future groups wishing to use pigs in airway research, will reduce numbers of animals used and improve animal welfare.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 338-343 |
| Number of pages | 6 |
| Journal | Laboratory Animals |
| Volume | 43 |
| Issue number | 4 |
| DOIs | |
| State | Published - Oct 2009 |
| Externally published | Yes |
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Keywords
- Experimental surgery
- Pain management
- Pigs
- Postoperative
- Transplantation
ASJC Scopus subject areas
- Animal Science and Zoology
- veterinary(all)
Cite this
Development of perioperative care for pigs undergoing laryngeal transplantation : A case series. / Murison, P. J.; Jones, A.; Mitchard, L.; Burt, R.; Birchall, M. A.
In: Laboratory Animals, Vol. 43, No. 4, 10.2009, p. 338-343.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Development of perioperative care for pigs undergoing laryngeal transplantation
T2 - A case series
AU - Murison, P. J.
AU - Jones, A.
AU - Mitchard, L.
AU - Burt, R.
AU - Birchall, M. A.
PY - 2009/10
Y1 - 2009/10
N2 - Pigs are ideal animal models for airway surgical research, facilitating the successful translation of science into clinical practice. Despite their ubiquitous use, there is a paucity of information on the perioperative care of pigs, especially for major procedures. In a series of experiments to investigate laryngeal transplantation, we combined veterinary and medical experience to develop protocols for perioperative management of pigs, including high dependency care. Novel airway management methods were developed. A pain scoring system was used to direct analgesia use. Fluid balance and electrolytes were monitored closely. Recent animals received a central venous line via the femoral vein two days prior to transplantation to facilitate blood sampling and drug delivery. Intensive monitoring and airway management were required to ensure a successful outcome. Methods for optimal perioperative care are proposed. These results will help future groups wishing to use pigs in airway research, will reduce numbers of animals used and improve animal welfare.
AB - Pigs are ideal animal models for airway surgical research, facilitating the successful translation of science into clinical practice. Despite their ubiquitous use, there is a paucity of information on the perioperative care of pigs, especially for major procedures. In a series of experiments to investigate laryngeal transplantation, we combined veterinary and medical experience to develop protocols for perioperative management of pigs, including high dependency care. Novel airway management methods were developed. A pain scoring system was used to direct analgesia use. Fluid balance and electrolytes were monitored closely. Recent animals received a central venous line via the femoral vein two days prior to transplantation to facilitate blood sampling and drug delivery. Intensive monitoring and airway management were required to ensure a successful outcome. Methods for optimal perioperative care are proposed. These results will help future groups wishing to use pigs in airway research, will reduce numbers of animals used and improve animal welfare.
KW - Experimental surgery
KW - Pain management
KW - Pigs
KW - Postoperative
KW - Transplantation
UR - http://www.scopus.com/inward/record.url?scp=70349444923&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=70349444923&partnerID=8YFLogxK
U2 - 10.1258/la.2009.008101
DO - 10.1258/la.2009.008101
M3 - Article
C2 - 19535394
AN - SCOPUS:70349444923
VL - 43
SP - 338
EP - 343
JO - Laboratory Animals
JF - Laboratory Animals
SN - 0023-6772
IS - 4
ER -