Development of perioperative care for pigs undergoing laryngeal transplantation: A case series

P. J. Murison, A. Jones, L. Mitchard, R. Burt, M. A. Birchall

Research output: Contribution to journalArticlepeer-review

17 Scopus citations


Pigs are ideal animal models for airway surgical research, facilitating the successful translation of science into clinical practice. Despite their ubiquitous use, there is a paucity of information on the perioperative care of pigs, especially for major procedures. In a series of experiments to investigate laryngeal transplantation, we combined veterinary and medical experience to develop protocols for perioperative management of pigs, including high dependency care. Novel airway management methods were developed. A pain scoring system was used to direct analgesia use. Fluid balance and electrolytes were monitored closely. Recent animals received a central venous line via the femoral vein two days prior to transplantation to facilitate blood sampling and drug delivery. Intensive monitoring and airway management were required to ensure a successful outcome. Methods for optimal perioperative care are proposed. These results will help future groups wishing to use pigs in airway research, will reduce numbers of animals used and improve animal welfare.

Original languageEnglish (US)
Pages (from-to)338-343
Number of pages6
JournalLaboratory Animals
Issue number4
StatePublished - Oct 2009
Externally publishedYes


  • Experimental surgery
  • Pain management
  • Pigs
  • Postoperative
  • Transplantation

ASJC Scopus subject areas

  • Animal Science and Zoology
  • veterinary(all)


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